Therapies available to Hospital for Large Animals patients include laser therapy
for uveal cysts, cyclosporine implants for equine recurrent uveitis, radiation and cryotherapy for different ocular cancers and state - of - the - art ocular ultrasound and ocular surgery.
While an in - house (MH Stern's team) developed technique (biPAP - PCR) showed exquisite sensitivity
for uveal melanoma mutations (Madic, Clin Cancer Res 2012), we developed other ctDNA techniques (ddPCR and NGS - based techniques).
Reported data suggests that inherited genetic factors associated with eye and skin pigmentation could increase a person's risk
for uveal melanoma.
Not exact matches
Aura additionally announced today that the U.S. Food and Drug Administration (FDA) has granted AU - 011 fast track designation
for the treatment of primary ocular melanoma, also known as
uveal or choroidal melanoma.
Uveal melanoma does not respond to the drugs given to patients with melanoma on the skin; and, in fact, there is no drug approved specifically
for treatment of the disease.
Though
uveal melanoma is rare — there are only 2,500 cases diagnosed in the United States each year — about half of patients will develop metastatic disease, and survival
for patients with advanced disease has held steady at nine months to a year
for decades.
The median survival rate
for patients with metastatic
uveal melanoma is 12 months.
«If we can confirm selumetinib's effectiveness in treating advanced
uveal melanoma in this follow - up trial, it will become the standard therapy
for this disease, forming a foundation
for new drug combinations that could maximize selumetinib's MEK - inhibitor effect,» he said.
In one of the balancing acts of medicine, the anti-inflammatory action of the drug also increases the risk
for other conditions, in this case, a rare form of eye cancer,
uveal melanoma.
Unlike other solid tumors, there has been limited progress in understanding the contribution of genetic risk factors to the development of
uveal melanoma, researchers say, primarily due to the absence of comprehensive genetic data from patients as the large sample cohorts
for this rare cancer type have not been available
for research.
New research links specific inherited genetic differences (alterations) to an increased risk
for eye (
uveal) melanoma, a rare form of melanoma that arises from pigment cells that determine eye color.
«But this data is also important because it indicates —
for the first time — that there is a shared genetic susceptibility to both skin and
uveal melanoma mediated by genetic determination of eye color.
NEW YORK, NY (June 19, 2014)--
For the first time, a therapy has been found that can delay progression of metastatic
uveal melanoma, a rare and deadly form of melanoma of the eye.