These results may provide new ways
for vaccine researchers to target HIV and may influence the design of future HIV vaccines.
Not exact matches
Researchers at Oregon Health & Science University are currently looking
for volunteers that can be tested during an upcoming clinical trial
for a
vaccine that may cure HIV, the virus that causes AIDS.
Researchers have developed a
vaccine for preventing allergic reactions to peanuts in laboratory mice.
Armed with that information, the
researchers then designed a mutant flu strain that was powerful enough to replicate well but highly susceptible to our body's own ability to control the virus — the ideal ingredients
for a
vaccine.
The
researchers are currently planning a follow - up study which will test whether a flu
vaccine is more effective
for the elderly when combined with brief use of Losmapimod.
There may also be other applications from this work, they say:
Researchers could similarly take other viruses apart in the lab, scour them
for important mutations and create
vaccines against a plethora of other infections.
But rather than dashing all hopes
for an AIDS
vaccine, the trial has heartened some
researchers, who see new clues in the battle against the fatal illness.
The hunt
for a universal flu
vaccine, a single shot that would provide lifelong immunity, has been going on
for decades, and many teams of
researchers have been on the case.
Researchers, including our team at Penn, are using it as a foundation
for developing
vaccines for other mosquito - borne illnesses like Zika and Dengue.»
This technology could help
researchers rapidly generate new peptide drugs to test on a variety of diseases, and it also raises the possibility of easily producing customized cancer
vaccines for individual patients.
«Although HPV
vaccine has been around
for more than a decade, the uptake of the
vaccine has been less than ideal in many places, including in high - resource countries such as the United States,» said Silvina Arrossi, PhD, co-chair of the Expert Panel that developed the guideline and an official and
researcher at the Instituto Nacional del Cancer in Buenos Aires, Argentina.
Studies that compare flu alterations in multiple people won't immediately tell
researchers how to design
vaccines, she says, but could point to parts of the virus
for further investigation.
Roughly a year after Brazilian doctors and
researchers first suspected a link between a spate of alarming birth defects and the Zika virus, a cadre of potential
vaccines are now headed
for testing in humans.
Yoshihiro Kawaoka of the University of Wisconsin - Madison, lead
researcher on the other study, adds that the meeting allowed him and Fouchier to explain their work, including the potential benefits
for surveillance of emerging flu strains (Nature 481, 417 - 418; 2012) and
for vaccine preparation (Nature 482, 142 - 143; 2012).
Researchers for the past decade have focused on the T cell approach, based on studies showing that monkeys receiving such
vaccines against simian immunodeficiency virus, related to HIV, lived longer or had lower viral levels than usual.
Having a readily available oral
vaccine for the wolves was a lucky break
for the
researchers in Ethiopia.
Researchers could then reverse - engineer barcodes
for the
vaccine, and thus the flu itself, as well as other diseases.
In collaboration with many
researchers (graduate students, postdocs, and faculty elsewhere), we have examined the role of cross-immunity on the evolution and dynamics of influenza; the impact of behavioral changes, long periods of infectiousness, variable infectivity, co-infections, prostitution, social networks, and
vaccine efficacy on HIV dynamics; the role of exogenous re-infection, variable progression rates, vaccination, public transportation, close and casual contacts on tuberculosis dynamics and control; the impact of life - history vector dynamics on dengue epidemics; and on the identification of time - response scales
for epidemics of foot and mouth disease.
Researchers from the University of Zurich and University Hospital Zurich now reveal which factors are responsible
for the human body forming such broadly neutralizing HIV antibodies, thereby opening new avenues
for the development of an HIV
vaccine.
An effective
vaccine against the virus that causes genital herpes has evaded
researchers for decades.
The genetic code also holds clues to Chlamydia's surface proteins, which Stephens says should give
researchers new targets
for vaccines, diagnostic tests, and drugs.
A major new finding that will significantly advance efforts to create the world's first antibody - based AIDS
vaccine was published today by
researchers from the La Jolla Institute
for Allergy and Immunology.
One contains the
vaccine —
for their tests, the
researchers used a liquid version of ovalbumin, a constituent of egg whites.
For some
researchers the big goal is to bump up the effectiveness of existing
vaccines, most of them made from chemically - killed influenza particles or proteins extracted from such particles (see «Anatomy of a killer virus»).
La Jolla Institute scientist Shane Crotty, Ph.D., a respected
vaccine researcher and member of one of the nation's top AIDS
vaccine consortiums, showed that certain helper T cells are important
for triggering a strong antibody response against HIV, the virus that causes AIDS.
The
researchers found that in mice, a single injection of 30 millionths of a gram of these mRNAs — a small fraction of the dose used
for a typical
vaccine — induced a rapid immune response, which protected mice from intravenous exposure to a separate Zika strain two weeks later.
If AIDS is caused by a virus, why has it been impossible
for researchers to develop a
vaccine after 20 years and millions of dollars spent?
By studying healthy people,
researchers from the National Institute of Allergy and Infectious Diseases (NIAID)
Vaccine Research Center, part of the NIH, and colleagues from King's College London have created a reference resource
for other scientists.
Johns Hopkins Bloomberg School of Public Health
researchers say a new candidate
vaccine against respiratory syncytial virus (RSV) made with a weakened version of the virus shows great promise at fighting the disease, the leading cause of hospitalization
for children under the age of one in the U.S.
And although treatment with rehydration salts and proper food can save lives,
researchers have been working
for years on a
vaccine that could reduce the severity of the disease, especially in developing countries with poor health care and nutrition.
Yale Cancer Center
researchers have developed a
vaccine strategy that reduces the risk of flu infections in cancer patients at highest risk
for influenza.
In a March 2009 study published in Genes and Immunity,
researchers at the National Center
for Computational Toxicology compared the genetic signatures of 16 people who experienced smallpox
vaccine side effects, including fever, rashes and enlarged lymph nodes, to 45 people who did not.
The
researchers also tested willingness to pay
for a
vaccine at various price points.
The
researchers» findings have major implications
for future
vaccine development.
In these countries pneumonia, malaria and diarrhea were the leading causes of death), so to improve survival in these regions the
researchers recommended improving the uptake of breastfeeding, providing
vaccines for pneumonia, malaria and diarrhea, and improving water and sanitation.
The
researchers hope that understanding the level of virus needed
for transmission of infection will provide a useful reference point
for the development of experimental drugs and
vaccines and could be used to inform the endpoints
for clinical trials evaluating such interventions.
Cincinnati Cancer Center (CCC) and UC Cancer Institute
researchers have found that a
vaccine, targeting tumors that produce a certain protein and receptor responsible
for communication between cells and the body's immune system, could initiate the immune response to fight cancer.
The
researchers studied 4,193 pregnant women; about half of the subjects received a flu
vaccine; the other half received a
vaccine for meningitis.
Researchers from Southern Medical University in Guangdong, Guangzhou, China, have developed an oral
vaccine against Helicobacter pylori, the bacteria responsible
for peptic ulcers and some forms of gastric cancer, and have successfully tested it in mice.
An exception to this trend is Dong Pyou Han, a former Iowa State University (ISU) biomedical
researcher who last week was sentenced to prison
for 57 months — almost 5 years —
for falsifying results in HIV
vaccine studies he participated in while working under lab head Michael Cho, The Guardian reports.
With this approach if validated
for other
vaccines, we only need to wait
for a week,» says
researcher Ali Harandi, who heads the participation of Sahlgrenska Academy and University of Gothenburg in the project.
Medical
researchers are working hard to develop effective
vaccines and other immunotherapy treatments
for pancreatic cancer.
The
researchers are planning to test this method to deliver HIV
vaccines in nonhuman primates, and they are also working on further developing cancer
vaccines, including one
for lung cancer.
The
researchers found a slight increase in the relative risk of febrile seizure with the MMRV
vaccine compared with the MMR+V
vaccine — about 1 excess seizure
for every 2841 doses administered in the 7 - to 10 - day period after vaccination.
University of Tübingen
researchers in collaboration with the biotech company Sanaria Inc. have demonstrated in a clinical trial that a new
vaccine for malaria called Sanaria ® PfSPZ - CVac has been up to 100 percent effective when assessed at 10 weeks after last dose of
vaccine.
Researchers led by a team at Duke University identified these immunologic variations by studying blood samples collected from people living with HIV by the NIAID - supported Center
for HIV / AIDS
Vaccine Immunology (CHAVI).
LONDON (Reuters)--
Researchers announced the launch of two big studies in Africa on Thursday to test a new HIV
vaccine and a long - acting injectable drug, fuelling hopes
for better ways to protect against the virus that causes AIDS.
The
researchers are now looking at how ICOS signals can be altered to diminish autoimmune disorders and augmented
for more effective
vaccine development, and are beginning research on how ICOS signaling may benefit Chimeric Antigen Receptor - T cell (CAR - T) therapies, which involves engineering of patient's own immune cells to recognize and attack their cancers.
The
researchers then tested each strain of the virus
for susceptibility to two potent and commonly used antibodies in
vaccine development experiments
for HCV, HC33.4 and AR4A.
Some
researchers have argued that lower doses may be slower to kick the immune system into gear, which could cause the
vaccine virus to linger in the body
for longer and actually increase the risk of some side effects.