Others including Randy Schekman had discovered NSF to be important
for vesicle trafficking and secretion in yeast, leading Rothman to argue that these proteins are involved in vesicle fusion in every cell of the animal kingdom — a universal mechanism for secretion.
Not exact matches
25 October 2013: The 2013 Nobel Laureates who published in Science include,
for Medicine, James E. Rothman, Randy W. Schekman and Thomas C. Südhof
for their discoveries of machinery regulating
vesicle traffic, a major transport system in our cells.
A protein that transports the simple chemical choline plays a major role in
vesicle trafficking, ion homeostasis, and growth and development in plants, according to two new studies publishing 28 December in the open - access journal PLOS Biology, by Dai - Yin Chao of the Shanghai Institutes
for Biological Sciences, China, and Sheng Luan of the University of California, Berkeley, USA, and co-workers.
Enrich points out that «in the cell, cholesterol controls the
trafficking of
vesicles, which are responsible
for transporting integrins to cell surface.
During a brief post-doctoral fellowship with Harvey Lodish at the Massachusetts Institute of Technology Rothman learnt to work with viruses and cell - free systems — thus acquiring skills that would later prove invaluable
for identifying molecules involved in
vesicle trafficking.
Endocytosis has traditionally been viewed as a mechanism
for achieving signal attenuation: activated cell surface receptors are internalised and
trafficked through endocytic
vesicles to lysosomes, where they are degraded.