Sentences with phrase «foreign gene in every cell»

One of the biggest advantages of the cultured sperm approach is that transgenic zebrafish created in this way carry the inserted, foreign gene in every cell of their bodies, including their germ cells.

«Conventional techniques of producing transgenic animals, such as microinjection of genes into eggs and the retroviral transduction of genes into embryos, often produce many animals that are mosaic, which means they do not contain the foreign gene in all their cells.

Not exact matches

Such analyses have tied Alzheimer's risk to several genes involved in innate immunity — the body's immediate defenses that indiscriminately attack pathogens and other foreign molecules and cells.

Defects in this gene mean it can no longer fulfil its role as a regulator that helps purge the body of autoreactive immune cells termed T cells that can react against the body's own proteins, mistaking them for a foreign invader.

They then stitched the genes for these immunoadhesins into an adeno - associated virus (AAV), a «vector» used in human gene therapy experiments to deliver foreign DNA into the body's cells.

The Great Ormond Street team was able to use donor T - cells to treat Layla because in addition to the CAR gene, they used gene editing to disable the gene for the protein that recognises other cells as foreign, thereby preventing the donor cells from attacking Layla's healthy cells.

Drawing upon the cell culture expertise of Noriyoshi Sakai, Ph.D., and Kayoko Kurita, of Fukui Prefectural University, the Japanese - U.S. team developed a system that enables immature sperm cells, or spermatagonia, taken from male zebrafish to survive long enough in vitro that they can receive foreign genes inserted by a retrovirus.

According to Dr. Burgess, the team is now working to extend the period that sperm cells can be cultured, so there is more time to select cells that have the foreign gene inserted in specific areas of the genome in what is commonly called a «targeted gene knockout.»

By expressing foreign genes in target cell types, they hope to be able to specifically silence or activate cells of interest.

The scientists had strategically inserted these foreign DNA «markers» at particular points along the genome, next to genes expressed only in embryonic stem cells.

The foreign gene introduced through the male germ cells glows under ultraviolet light in the photograph of transgenic mice.