It was unknown which kinds of stem cells
form myofibroblasts, and where these stem cells are located.
The AHR ligands turned on AHR - dependent genes and blocked the TGFβ - driven transformation of human orbital fibroblasts to scar -
forming myofibroblasts.
Not exact matches
Now they've discovered additional factors actually produced by the regenerating hair follicle to convert the surrounding
myofibroblasts to regenerate as fat instead of
forming a scar.
The most common cells found in healing wounds are
myofibroblasts, which were thought to only
form a scar.
The orbital remodeling in TED is likely induced by infiltrating T lymphocytes and mast cells, which activate orbital fibroblast effector cells to either proliferate and
form scar - producing cells called
myofibroblasts or turn into pro-inflammatory fat cells.
But heart cells never truly regenerate in the damaged tissue, and
myofibroblasts compensate for their absence by
forming a stiff, collagenous scar that interferes with the heart's ability to maintain stable heart rhythms and to expand and contract forcefully to pump blood.