One such compound was docetaxel, an anticancer drug that binds tubulin, and the other jasplakinolide, which specifically binds the cytoskeletal
form of actin.
Penn Vet researchers showed that differences in the order of nucleotides — not the amino acids — governed the distinct functions of two
forms of actin.
Not exact matches
At the center
of the discovery is a protein called
actin, which
forms fibers that span the cytoplasm
of cells to create the cell's cytoskeleton.
When that protein is added to the receptor, the receptor gets taken out
of its nanodomain and becomes caught up in the
actin filaments that
form the cell's cytoskeleton.
When the
actin polymerization occurs at one spot on the surface
of an autophagosome, which coincides with the location
of WHAMM on these organelles, an
actin comet tail is
formed, and the rapid assembly / disassembly
of the
actin polymers «pushes» the autophagosome toward the lysosome for final processing.
Through live imaging, they found that a ring comprised
of the protein
actin forms between the two daughter cells to block cytokinesis from proceeding.
New research at Rice University suggests
actin filaments that control the shape
of neuron cells may also be the key to the molecular machinery that
forms and stores long - term memories.
Actin is a filamentous protein, which together with other cytoskeletal elements
forms a dynamic network
of filaments that provide both structural support, as well as critical functional capabilities, to the cell.
Actin allows vital actions to be performed by assembling and disassembling itself spontaneously, continually and rapidly in the
form of filaments that organize themselves and
form networks
of parallel bundles or intertwined meshes (known as lamellar networks).
The gene discovered in the research couples the exocytosis - regulating protein Sec10 with formin, a protein that regulates the remodeling
of the
actin cytoskeleton critical to
forming cell shapes.
Szymanski and his fellow researchers found that
actin fibers run throughout the cell,
forming a network
of long - distance «roadways» along which additional materials for the cell wall are transported.
«We were able to show by live cell imaging that polarization
of the cell occurs after fertilization
of the egg cell, and both MTs and F -
actin play a role in inducing asymmetric cell division to
form the plant's body axis,» says Ueda.
Actin, the protein that makes up the cytoskeleton, can
form long filaments that grow in one direction and networks
of filaments.
Pai and Kabsch were part
of a group that collaborated to solve the first
actin structure, a challenge because muscle proteins polymerize and don't
form crystals.
Actin filaments
form different polymer networks with versatile mechanical properties that depend on their spatial organization and the presence
of cross-linkers.