Sentences with phrase «form of cell lines»

In May 2001, the U.S. Justice Department charged two Japanese - born scientists with conspiring to «benefit a foreign government» by stealing trade secrets in the form of cell lines and DNA samples from a laboratory at the Cleveland Clinic Foundation in Ohio, where one had worked from 1997 to 1999 (Science, 18 May 2001, p. 1274).

Not exact matches

The theory of societies, like modern general systems theory, pictures a world made up of societies within societies (systems within systems) That is, societies do not just line up side by side like mosaics — they form «nested hierarchies» that go from subatomic particles through cells to animal bodies, or through stars to galaxies.

«NATURAL killer» cells form the front - line troops of the immune system.

Furthermore, the form is self - dual, meaning that if you draw lines between the centers of every facet in the 11 - cell, you get another 11 - cell.

Epithelial cells form tissue layers that cover our skin and the inner surfaces of most of our internal organs, while endothelial cells line the adjacent blood - transporting vessels and capillaries that support their functions.

Researchers are also experimenting with another form of immunotherapy called adoptive cell transfer, which harvests and then reintroduces patients» tumor - infiltrating lymphocytes — cells with anti-tumor capabilities that dig deep behind enemy lines.

This results in shifts in the structure of the brain as it forms and displacement of cells from where they're supposed to be, including those that line the ventricles and help control fluid flow.

Until 2009, Saitou's starting point had been cells taken from a live mouse epiblast — a cup - like collection of cells lining one end of the embryo that forms at the end of the first week of development, just before the PGCs emerge.

«The key unanswered question here concerns when on the eukaryotic line the eukaryotic type of cell formed.

Odontoblasts line up side by side inside the developing tooth to form a sheet of columnar cells that deposit dentin.

«Active HSCs (hematopoietic stem cells) form the daily supply line that continually replenishes worn - out blood and immune cells while the reserve pool serves as a backup system that replaces damaged active HSCs and steps in during times of increased need,» explains Li.

Using nanoparticles designed and screened for endothelial delivery of short strands of RNA called siRNA, the researchers were able to target RNAi to endothelial cells, which form the linings of most organs.

To determine whether endothelial cells — the cells that line the interior surface of blood vessels — directly influence breast cancer cell growth, they then created unique organotypic models of lung and bone marrow microvascular niches, in which endothelial cells formed blood vessel - like structures in culture as they would in the original organ.

Mice lack colonic BMI - 1 stem cells that play a critical role in how colon cancer forms — or carcinogenesis — and how material passes through the cell lining of the intestinal wall — or gut permeability.

It both promotes angiogenesis within the tumor and increased the migration of endothelial cells, which form the inner lining of blood vessels.

Biochemist Nirenberg of the National Institutes of Health gave a seminar describing a groundbreaking experiment in which he and a colleague had discovered how the cell interprets messenger RNA — by reading one triplet, or codon, of nucleotide bases at a time — to line up the amino acids that form proteins.

The paper took this form: Molecule X from lichen species Y inhibits the growth of cancer cell Z. To substitute for those variables, I created a database of molecules, lichens, and cancer cell lines and wrote a computer program to generate hundreds of unique papers.

They are generating β cells from those cell lines to look for differences that might explain how the different forms of the disease develop.

They tried hundreds of different recipes; eventually they discovered that if they mixed liver precursor cells (derived from iPS cells) with two other types of standard human cell lines known to be important for embryonic liver development, then the cells would spontaneously form a 4 to 5 - millimeter 3D structure called a liver bud.

Biologists who study the mechanics of cell division have for years disagreed about how much force is at work when the cell's molecular engines are lining chromosomes up in the cell, preparing to winch copies to opposite poles across a bridge - like structure called the kinetochore to form two new cells.

Pursuing another strategy, scientists at San Diego Zoo in California last year showed that banked tissue from the almost extinct northern white rhino (Ceratotherium simum cottoni) could be induced to form a line of pluripotent stem cells, capable of forming many tissues.

The transplanted stem cells had differentiated into endothelial cells — which form the inner lining of a blood vessel, providing a barrier between blood and spinal cord tissue — and attached to capillaries in the spinal cord.

It took advantage of the brain's own mechanism for getting a necessary nutrient, iron, across the lining of endothelial cells that form the blood - brain barrier.

To overcome this, researchers from the University of Texas Southwestern Medical Center and Johns Hopkins University stabilized pri - miRNAs by expressing a dominant negative form of DROSHA, the RNase III enzyme responsible for pri - miRNA cleavage, in a variety of human and mouse cell lines.

Researchers at the University of Illinois at Chicago have discovered a novel molecular mechanism that tightens the bonds between the cells that line blood vessels to form a leak - proof barrier.

Tumors form in the pleura, a thin membrane of cells that line the lungs and chest wall.

This response is triggered when the ER, part of the cell's protein assembly line, struggles to fold newly formed proteins into their exactly right shapes.

The FDA granted accelerated approval to avelumab (Bavencio, EMD Serono, Inc.), a checkpoint immunotherapy that targets the PD - 1 pathway, as a first - line treatment for a rare form of skin cancer called Merkel cell carcinoma (MCC).

To do so, they started with a human embryonic stem cell line, which they chemically nudged to become cells that form what's known as the primitive streak on the hollow ball of cells of the early embryo.

The hematopoietic stem cells that last the lifetime of the organism form within nodes of the mesoderm that line the mesentery and the major blood vessels.

Significantly increased expression of OCT4 and ABCG2 in spheroid body - forming cells of the human gastric cancer MKN - 45 cell line.

Medical oncologist Alexander T. Pearson, MD, PhD cares for adults with head and neck cancers, especially squamous cell carcinoma, a common form of cancer that develops in the squamous cells that make up the middle and outer layer lining the mouth and throat.

The mouse lines, which will be stored in the form of frozen embryos, frozen sperm and frozen embryonic stem (ES) cells, will be delivered to NIH - funded mouse repositories that supply mice to universities, medical schools and research labs all over the world.

The next step based on these novel head and neck cancer discoveries, the scientists agree, is to tease out how the genes function in normal cells, whether they form the lining of the larynx, pharynx, or another anatomical site affected by head and neck cancer.

The team then selected cells from these organoids and placed them inside the Intestine - Chips, which are about the size of AA batteries and re-create the natural microenvironment of the human intestine, including the intestinal epithelium — the layer of cells that forms the lining of both the small and large intestines.

Stem cell researchers from UCLA used a high resolution technique to examine the genome, or total DNA content, of a pair of human embryonic stem cell lines and found that while both lines could form neurons, the lines had differences in the numbers of certain genes that could control such things as individual traits and disease susceptibility.

By collecting and banking your stem cells — especially while you are healthy — you are collecting a large number of stem cells and an array of differentiated cell lines, including the ones committed to form immune cells.

In the Intestine Chip, the epithelium forms villi - like projections lined by polarized epithelial cells that undergo multi-lineage differentiation similar to that of intestinal organoids, however, these cells expose their apical surfaces to an open lumen and interface with endothelium.

These cancers develop from the cells that form the innermost lining of the stomach.

However, there is a fine line between the DNA damage that forms an essential part of B cells» life and DNA damage that could end it.

About 9 out of every 10 kidney cancers are renal cell carcinomas — cancers that form in the lining of the tubules inside the kidney.

He could have left the funding of research involving cell lines created by the destruction of human embryos in place, and led the charge to promote ethically unproblematic non-embryo-destructive forms of stem cell science.

To further investigate the role of STAT6 in regulating constitutive COX - 2 expression, a deleted form of STAT6 lacking the C - terminal 186 amino acids (aa)(from 662 - 847, MW 75 kDa) that has been shown to act dominant - negatively (STAT6 DN) was constructed and stable cell lines were established (Mikita et al., 1996).

Cells of a human intestinal lining, after being placed in an Intestine - Chip, form intestinal folds as they do in the human body.

They are sometimes known as the sentinel cells of the immune system, constantly patrolling the borders of the body that form the physical barriers to the outside world — the skin and the inner linings of the lungs, nose, stomach and gut.

Editing GalNAc - T6 out of a colon cancer cell line changed its growth form to one more closely resembling healthy colon tissue.

The intestinal epithelial cells (IECs) that line the gut form a robust line of defense against ingested pathogens.

The mouse lines, most of which are stored in the form of frozen embryos, frozen sperm and frozen embryonic stem (ES) cells, are distributed using a Deltagen Standard Academic License Agreement.

This lining consists of a layer of epithelial cells that come together to form a barrier that is impenetrable to the nanoparticles, thereby necessitating the use of injections to be an effective form of treatment.

The mouse lines, most of which are stored in the form of frozen embryos, frozen sperm and frozen embryonic stem (ES) cells, are distributed using a Lexicon simple Letter Agreement.