Sentences with phrase «form tumours»

However, when these mice were tested for the ability to form tumours after activation of an oncogenic signal that causes colorectal cancer in humans, they showed dramatic resistance to tumor formation.

Remarkably, normal tissues restrain the expansion of mutant clones, so very few of them progress to form tumours.

If that happens, these cancerous cells become virtually undetectable, free to multiply unabated, and form tumours.

This has always been a worry with tissues produced from embryonic stem cells, as these have the capability to form tumours if any are left in their original state in the transplanted tissue.

Researchers have discovered that hydra (coral - like polyps that emerged hundreds of millions of years ago) form tumours similar to those found in humans.2 Thomas Bosch, at Kiel University, and Domazet - Lošo, from the Catholic University of Croatia in Zagreb unexpectedly discovered tumour - bearing polyps in two species of hydra.

That's because the new technique yields cells that have a lower, but not negligible, risk of forming tumours once implanted.

These findings could help researchers figure out how human iPSCs can be used for treating patients without forming tumours, which is one of the major challenges associated with undifferentiated iPSCs.

In other words, what are the genes that are sending the signal to these lung BMICs to leave the lung tumour, go into the blood stream, invade the blood - brain barrier and form a tumour in the brain.»

Once a cell has turned cancerous, it divides until a mass of cells forms a tumour.

Not exact matches

Although these spots themselves are harmless, if some of the spots are bigger than a 50 cent coin, then it could be due to Neurofibromatosis (NF), which is a genetic disorder of the nervous system that causes abnormal cell growth of nerve tissues or benign tumours to form on the nerves anywhere in the body at any time.

The AR - V7 variant is formed when an androgen receptor loses the end part of the receptor, called the C - terminal end; this is deleted due to an error in RNA processing in tumour cells, leaving only the beginning part of the receptor, the N - terminal end.

Because such cells are derived from adult cells, not pluripotent cells — which have the potential to form a kind of tumour called a teratoma — they might be safer than iPS cells.

Molecular characterization of the cells that undergo cell fate transition upon oncogenic Pik3ca expression demonstrated a profound oncogene - induced reprogramming of these newly formed cells and identified gene expression signatures, characteristic of the different cell fate switches, which was predictive of the cancer cell of origin, tumour type and clinical outcomes in women with breast cancers.

First, the genes used for reprogramming are themselves known to trigger cancer, so if they were to reactivate could cause tumours to form.

Dr Iain Foulkes, director of research and innovation at Cancer Research UK, said: «We urgently need new insights and treatments to tackle glioblastomas, one of the most common and difficult to treat forms of brain tumours.

Dr Harry Bulstrode at the University of Cambridge has received a Cancer Research UK Pioneer Award * to test the effect of the Zika virus on glioblastoma, the most common and aggressive form of brain tumour.

The main reason why people die of cancer is that the cancer cells spread to form daughter tumours, or metastases, in vital organs, such as the lungs and liver.

A «Trojan horse» treatment for an aggressive form of brain cancer, which involves using tiny nanoparticles of gold to kill tumour cells, has been successfully tested by scientists.

The real test will be to inject these cells into mice and see if they form teratomas — tumours containing tissue or structures derived from all three germ layers.

Like a cruel form of mind control, some cancerous tumours can reprogram some immune cells to «block» other immune cells from attacking, leaving the tumour free to grow.

The tumour cells pass between individuals during biting behaviour and tumours form predominantly around the face and neck, grow rapidly and cause close to 100 per cent mortality.

Cardiff University scientists have developed a novel anti-cancer stem cell agent capable of targeting aggressive tumour forming cells common to breast, pancreas, colon and prostate cancers.

Around 15 per cent of women with breast cancer have this form of the disease, in which tumour cells lack the three receptors that most drugs target.

In the body they form metabolites that react readily with DNA to produce mutations that in turn can cause tumours.

While this led to fertile sperm, it also caused tumours to form in between 29 and 50 per cent of mice.

Batimastat does not work this way: instead, it is designed to keep cancers in check by preventing malignant cells breaking away and forming secondary tumours elsewhere in the body.

After treatment, the tumour shrinks, forms a scab and falls off, leaving fresh skin underneath that heals completely, she says.

Until now, it was not clear which form of cell death is decisive for the development of malignant liver tumours.

Such secondary tumours are formed when individual cells break away from the main tumour and travel through the bloodstream to distant areas of the body.

When they enter the brain, they generally form multiple tumours and can be extremely difficult to treat.

Most of the studies have focused mainly on tumour cells, whilst the cells that form the stroma are the great unknown, in spite of different research groups proving that some components of stroma promote the tumour progression.

The study, which is published in the journal Nature Communications, was conducted on human tumour cells and on mice, and offers hope of a much improved therapy for a severe form of cancer.

When the two species were put into mice predisposed to get bowel cancer, the number of tumours that formed dramatically increased (Science, doi.org/cj4w).

So when its production is reduced, a tumour may start to form.

Scientists have identified for the first time the «cell of origin» — in other words, the first cell from which the cancer grows — in basal cell carcinoma, the most common form of skin cancer, and followed the chain of events that lead to the growth of these invasive tumours.

First a few cells begin to divide out of control and form a primary tumour.

Once these secondary tumours form, it is often too late to save a patient.

The researchers then conducted experiments to have the hydrogel scaffold form at the surgical site after removal of primary tumours.

An international team of researchers has found a drug previously approved to treat breast cancer could also be used to shrink medulloblastoma, a common form of childhood brain tumour.

There is substantial clinical impact of performing genetic profiling of tumour samples in order to identify specific mutations and match those mutations with targeted therapies; one of the earliest forms of «personalised» or «precision» medicine.

To identify procedures and safety systems that will allow complete elimination of proliferative and / or tumour - forming cells from the graft cell preparations;

Currently, four projects are being run aimed at developing new, effective treatments for both haematological forms of cancer (leukaemia) and solid tumours.

Metastasis is the process by which cancer cells spread from one organ to another, forming secondary tumours.

Understanding the processes that restrain mutant cells from developing into tumours, and how they are breached when cancers do form will guide the development of strategies to reduce the chance of cancer development in individuals who have acquired a high level of mutations.

Upon orthotopic transplantation into immunodeficient mice, these organoids form normal pancreatic ducts and acinar tissue resembling fetal human pancreas without evidence of tumour formation or transformation.

Moreover, we have shown that lymph nodes draining a tumour (TDLNs) form part of the extended tumour microenvironment, adapting to tumour - derived signals.

They also form a platform for discovering fibroblast lineages in other tissues and for examining fibroblast changes in ageing and disease (i.e, tumour formation).

Cancer cells multiply quickly and in a way that is out of control; this is how tumours are formed.

Researchers from Lund University and Stockholm University / SciLifeLab have now found a genetic change that causes the benign tumour forms.

The afternoon of the second day focused on somatic changes in melanoma, that is changes that occur in the tumour itself, and this session saw talks from ESR07 Sofia Chen on the mutational landscape of primary melanoma tumours; ESR08 Catarina Salgado on DNA hydroxymethylation (a form of regulation) in melanoma and naevi; and ESR10 Adriana Sanna on epigenetic regulation (reversible changes to the DNA which can turn genes on / off) of melanoma cell phenotypes.