Limitations include the 54.5 % participation rate, the reliance on
a formal psychiatric diagnosis of ODD / CD in the child as the outcome measure, and the lack of follow - up with the untreated control group sample.
«There is no doubt that mefloquine does cause more sleeplessness, abnormal dreams, anxiety and depressed mood than the alternatives» says Dr Tickell - Painter, «but the review clarifies that these are symptoms reported by people taking mefloquine and not
formal psychiatric diagnoses.
(1) Our data are derived from children / adolescents (and mothers) referred to our tertiary Headache Center and may not be representative of the whole pediatric population suffering from migraine without aura; (2) The psychological tools employed in our study (TAS - 20, ASQ, SAFA - A, D, and S) have a self - report nature; although, they have been considered valid for psychological screening, they are not suitable for a
formal diagnosis of
psychiatric disorder; moreover, ASQ, as a self - report questionnaire, may not be able to elicit stress and danger situations, which are indispensable to activate the attachment system; (3) In future studies, it would be important to further explore not only the role of maternal attachment and alexithymia but also the role of maternal migraine features on their children's migraine severity, attachment style, and psychological profile.