IN BRIEF Scientists have new evidence that suggests that THC inhibits
the formation of amyloid plaques by blocking the enzyme in the brain that produces them.
One drug blocks an enzyme essential to
the formation of amyloid plaques that are thought to cause the disease.
«This implies that the astrocytes could be reacting against
the formation of amyloid plaques by modifying their function rather than changing position, concludes Galea.
The results showed that amyloid plaque levels in the posterior cingulate cortex were related to the amount of white matter damage, suggesting that injury to the brain's wiring may be linked to
the formation of amyloid plaques.
Next, the researchers investigated how microglia training and tolerance affected
the formation of amyloid plaques in the long term.
In another rodent study published this week in Science Translational Medicine a group of researchers from multiple institutions identified a pathway responsible for
the formation of amyloid plaques.
In persons with the disease,
the formation of amyloid plaque aggregates, a process known to cause the onset of Alzheimer's disease, prevents the Crtc1 protein from functioning correctly.
The research found that slowly depleting the presence of a certain enzyme can reverse
the formation of amyloid plaques in the brain.
Many of the current drugs being explored act to stop
the formation of amyloid plaques in the brain which mean they may need to be given early in the disease process.
He and his colleagues bucked the trend within the pharmaceutical industry, which has focused on the biological pathways involved in
the formation of amyloid plaques, the dense deposits of protein that characterize the disease.
It is theorized that the anti-inflammatory spice with powerful antioxidant properties inhibits
the formation of amyloid plaque, a major cause of dementia.