Sentences with phrase «formation of tumor growth»

Not exact matches

It is this overproduction of superoxide that leads to the formation of metastasis and, consequently, the growth of a tumor.

«This led to formation of tumor - like growths.»

Less suppression of the immune response and less blood vessel formation in the tumor leads to less tumor growth.

These TAMs suppress the immune system and stimulate blood vessel formation thereby stimulating the growth of the tumor.

But most importantly, the researchers say, in three laboratory tests of tumor growth, the drug strongly blocked tumor formation in distant metastases and their precursors.

Researchers at the University of Mississippi recently found that ethanol — the alcohol in alcoholic drinks — speeds tumor growth by stimulating blood vessel formation.

Joining forces with dermatologists and oncologists from the University Hospital in Zurich and backed by the University Research Priority Program «Translational Cancer Research,» Sommer's team was able to demonstrate that, in melanoma cells, the epigenetic factor EZH2 controls genes that govern tumor growth as well as genes that are important for the formation of metastases.

One drug attacks cancer cells; the other inhibits cancer cell formation and the growth of blood vessels at tumor sites.

Petris says that understanding the roles of copper in biology may have far - reaching health implications for the general population because copper underpins many facets of biology, including the growth of cancer tumors and the formation of toxic proteins in Alzheimer's disease.

Due to the lack of oxygen in the cancer cells, VEGF - A (Vascular Endothelial Growth Factor) is formed and this promotes the formation of new blood vessels to supply the tumor.

Using a mathematical modeling approach, scientists have found that certain parameters of tumor growth in mice can predict the effectiveness of drugs that block formation of tumor - nourishing blood vessels.

When a chemical that inhibits entosis was applied to a line of breast cancer cells, colony formation — an indicator of tumor growth in vitro — increased 10-fold.

Because tumor growth is a concern when cells are reprogrammed to an earlier stage of development, the researchers followed the mice in the Nature Cell Biology study for nearly a year to look for signs of tumor formation and reported finding none.

«The CDK4 and 6 proteins are critical drivers of the cell - division cycle and are required for the formation and growth of various types of solid tumors,» says Dana - Farber's Shom Goel, MD, PhD, co-first author of the study with Molly DeCristo of the Hematology Division at BWH.

Knowing that insulin can stimulate the growth of blood vessels, «our expectation was that knocking out insulin signaling in these cells might slow the growth of blood vessels and reduce tumor formation in these mice,» Rask - Madsen says.

Biocellion is being used to model a variety of biological system behaviors, such as biofilm formation and wrinkling, microbial growth dynamics in complex soil structure, brain tumor growth and invasion, formation of complex bacterial colonies, and changes in blood vessels and skin cells.

To explore the biological function of DDX3 on cell growth control, a colony formation assay was done in several tumor cell lines (HuH - 7, HCT116, and HeLa) and normal murine fibroblast cells (NIH 3T3) under the selection of G418.

She is institutional principal investigator of the Phase I Consortium Study in New Agents in Neuroblastoma Treatment and directs NIH - funded work on effects of SPARC (secreted protein acidic and rich in cysteine, an amino acid) on neuroblastoma tumor growth and blood vessel formation.

The model will describe cellular pathways that contribute to tumor formation and explain in detail how the genetic disposition of an individual can activate expression of genes that drive uncontrolled cell growth and lead to cancer.

We also found that the EphB4 receptor expressed on the surface of breast cancer cells can promote tumor xenograft growth by enhancing blood vessel formation through interactions with its preferred ligand, ephrin - B2, present in tumor endothelial cells.

In cancer, researchers suspect that amplification causes an overproduction of SOX2 proteins that, in turn, reignites and sustains cell growth associated with tumor formation.

Silencing of the enzyme stimulated vessel formation, but paradoxically resulted in a profound reduction of tumor growth; an effect that relies on the anti-proliferative nature of the TGFβ signaling pathway, in a largely HIF1α - independent manner (Klotzsche - von Ameln et al., Cancer Res., 2011 and Cancer Biol Ther., 2012).

We report that tumor cells without mitochondrial DNA (mtDNA) show delayed tumor growth, and that tumor formation is associated with acquisition of mtDNA from host cells.

The central focus of my future work is to elucidate the mechanisms by which tumorigenesis results in the conversion of TGFβ from a suppressor of tumor formation to a promoter of tumor growth, invasion, and metastasis.

In contrast to the transformation of HMEC - DD cells, one oncogenic event is sufficient to transform Rat1 - DD cells, indicated by both anchorage - independent growth in vitro and tumor formation in vivo (Ni et al., 2012).

Knudson's revolutionary two - hit theory of cancer formation enabled me to discover the first imprinted tumor suppressor gene, the Insulin like Growth Factor 2 Receptor (IGF2R), propelling me into the field of epigenetics.

They also act aggressively against cancer by preventing cancer cell proliferation, inducing apoptosis — or cancer cell «suicide» — and inhibiting the formation of new blood vessels that nourish tumor growth.

Polyunsaturated fats such as corn oil and soybean oil are highly unstable and vulnerable to oxidation — and oxidation, in turn, is linked to cancer — while the omega - 6 fatty acids that predominate in vegetable oils have been shown to accelerate the growth of tumor cells.6 As Fallon and Enig explain, 4 excessive consumption of toxic polyunsaturated oils — not red meat — represents a known mechanism for colon cancer: «Colon cancer occurs when high levels of dietary vegetable oils and hydrogenated fats, along with certain carcinogens, are acted on by certain enzymes in the cells lining the colon, leading to tumor formation» [Emphasis added].

Free radicals have been linked to the formation and growth of tumors, as well as autoimmune diseases as a result of inflammation.

Cancer is the unregulated growth of cells in the body, often resulting in the formation of a mass or lump called a tumor.