«This could potentially have a therapeutic effect in adults with cancer, where generally there will not be any newly
forming blood vessels except within the growing cancer.
Some tumor cells use a newfound mechanism to communicate with healthy cells next to them and prompt those neighbors into
forming blood vessels.
The procedure does not work in the abdomen and instead resulted in inflammation and the transplanted fat not
forming blood vessels or attaching properly.
Yuichi Oike of Keio University in Japan and colleagues initially engineered mice that express large amounts of a protein known as angiopoietin - related growth factor (AGF) in order to study its role in
forming blood vessels.
«Yet after AA147 treatment, around 70 percent of the culture turned into endothelial cells that were able to
form blood vessels.
This intricate regulation process allows stem cells to maintain their ability to undergo self - renewal and
form blood vessel - like structures.
The researchers confirmed this hypothesis by showing that if they blocked YAP1 they could inhibit stem cells from undergoing self - renewal,
forming blood vessel - like structures, and reduce lung cancer cell growth in mice.
To determine whether endothelial cells — the cells that line the interior surface of blood vessels — directly influence breast cancer cell growth, they then created unique organotypic models of lung and bone marrow microvascular niches, in which endothelial cells
formed blood vessel - like structures in culture as they would in the original organ.
We found a drug that could push this process forward, making even more endothelial cells that help
form blood vessels.
Yet, unlike normal tissue, these newly
formed blood vessels are disorganized, twisty, and leaky.
Peter Carmeliet and his team demonstrated that endothelial cells can be paralyzed by blocking glycolysis and consequently stop to
form blood vessels.
These cells, often referred to as bone marrow stroma cells, develop during bone formation, from the early osteoprogenitor cells which later invade along
the forming blood vessel and enter the bone marrow.
Tumors make too much VEGF in their haste to
form blood vessels, which turns on the receptor complex.
SAN FRANCISCO, CA — The ability to
form blood vessels is one of evolution's crowning achievements, and something that separates vertebrates (animals with a backbone) from the rest of the animal kingdom.
Most previous work on wound healing in diabetes has focused on the types of cells that are involved in wound healing such as immune cells, skin cells and the cells that
form blood vessels.
He has determined that the growth and spread of cancer cells are dependent on their ability to
form blood vessels.
In edema, either too much fluid moves
form the blood vessels into the tissues, or not enough fluid moves back into the tissues.
Arteriovenous Malformations (AVM) are defined as a tangle of abnormal and / or poorly
formed blood vessels that create a «knotted cluster».
Not exact matches
The host's body will try to stop the bleeding by constricting
blood vessels and coagulating the
blood to
form a clot.
Biofilms
form endocasts and once dissolved out of the bone, mimic real
blood vessels and osteocytes.
Blood cell size iron - oxygen spheres found in the
vessels were identified as an oxidized
form of formerly pyritic framboids.
Vascular is the type that can be dangerous, they occur when the
blood vessels don't
form correctly.
Since the umbilical cord is a living tissue that contains
blood vessels, baby belly button will not immediately
formed after cutting it.
It is these cells that grow to
form the placenta, an organ that is entirely made up of
blood vessels.
Instead of preparing to
form fingers and toes and a brain like the rest of the embryo's cells, these ones are destined to
form a disc - shaped organ that's chock - full of
blood vessels and will take over for the corpus luteum in the second trimester: the placenta.
The middle layer
forms the heart,
blood vessels, bones, muscles and reproductive system.
The baby's eyes can blink and the heart and
blood vessels are fully
formed.
This is the first time researchers looked at newly
formed neurons and the state of
blood vessels within the entire human hippocampus soon after death.
The
blood - brain barrier,
formed by
blood vessels, protects the brain from toxins circulating in the body's
blood system.
The titanium frame with its bone - growing ingredients were then implanted into a layer of muscle on the patient's right shoulder blade to
form tissue and
blood vessel connections to the muscle.
In lab dishes, the blast cells
formed tissues that resembled
blood -
forming stem cells as well as
blood vessels, the group found.
Moreover, whereas the
blood vessel cells that resulted could also
form capillarylike structures, they and the retinal cells aged prematurely, losing their ability to divide.
However its current use as a treatment to block new
blood vessel growth in the wet
form of age - related macular degeneration means there is already a body of research from which we can perhaps draw useful insights.
New bone
forms to fill in the gaps, and — when the stretching is done gradually — the
blood vessels, muscles, nerves, and tendons keep pace.
Vibration helped tissue to
form new
blood vessels — a process called angiogenesis — and also led to increased expression of pro-healing growth factors and signaling molecules called chemokines, Weinheimer - Haus said.
The hydrogel would be injected in liquid
form and would polymerize in the transplant site, creating a flexible gel that would conform to bodily structures to improve both
blood vessel connections and tissue integration.
Epithelial cells
form tissue layers that cover our skin and the inner surfaces of most of our internal organs, while endothelial cells line the adjacent
blood - transporting
vessels and capillaries that support their functions.
Similar patches and treatments have already been tested against the «wet»
form — in which
blood vessels invade and destroy the retinal pigment epithelial cells that nourish and support the photoreceptor cells that capture light.
The network of
blood vessels in the brain regulates the transport of energy and materials in and out of the brain —
forming what is known as the
blood - brain barrier (BBB).
A critical discovery in this research was finding that the novel progenitor has a receptor protein on its cell surface called KDR, or vascular endothelial growth factor receptor 2, which until now, was thought to be restricted to endothelial cells that
form vessels, the progenitors for endothelial cells and the progenitors
blood cells.
In July Genentech announced that the drug Lucentis stabilized or even improved vision in a yearlong clinical trial of patients with so - called wet macular degeneration, a
form that involves overgrowth of
blood vessels.
The device can treat either
form of age - related macular degeneration: the dry stage, where the delicate tissues of the macula become thinned and slowly lose function, or the less common wet stage that's caused by the growth of abnormal
blood vessels behind the macula.
Because the protein is normally found outside of
blood vessels in the human brain, this suggests that plaques may
form in a different way in chimps.
Yin is using zebrafish to study the regeneration of heart tissue because of the amazing capacity of these common aquarium fish to regenerate the
form and function of almost any body part, including heart, bone, skin and
blood vessels, regardless of their age.
The trophoblast cells branch out to
form the labyrinth, and they are accompanied by fetal
blood vessels.
When BRCA1 is mutated, ANG1 switches on, new
blood vessels are
formed, and cancer cells get the nutrients critical to their survival.
Based on the pioneering work of Dr. Claire Lugassy and Dr. Raymond Barnhill at UCLA's Jonsson Comprehensive Cancer Center, a new study provides additional support for a process by which melanoma cells, a deadly
form of skin cancer, can spread throughout the body by creeping like tiny spiders along the outside of
blood vessels without ever entering the
blood stream, and that this process is exacerbated by exposure to ultraviolet (UV) light.
Even in its current
form, the team has shown that the AngioChip can be implanted into a living animal, its artificial
blood vessels connected to a real circulatory system.
Hookworms are among the oldest life
forms on Earth, and when they sink their teeth into our
blood vessels, they cause nausea, anemia, cramping, and more.
Within the
blood vessels of the brain, endothelial cells and other adjacent cells
form a tight barrier that helps to prevent toxins and microbes from entering the brain.