The AHR ligands turned on AHR - dependent genes and blocked the TGFβ - driven transformation of human orbital fibroblasts to scar -
forming myofibroblasts.
It was unknown which kinds of stem cells
form myofibroblasts, and where these stem cells are located.
Not exact matches
Now they've discovered additional factors actually produced by the regenerating hair follicle to convert the surrounding
myofibroblasts to regenerate as fat instead of
forming a scar.
The most common cells found in healing wounds are
myofibroblasts, which were thought to only
form a scar.
The orbital remodeling in TED is likely induced by infiltrating T lymphocytes and mast cells, which activate orbital fibroblast effector cells to either proliferate and
form scar - producing cells called
myofibroblasts or turn into pro-inflammatory fat cells.
But heart cells never truly regenerate in the damaged tissue, and
myofibroblasts compensate for their absence by
forming a stiff, collagenous scar that interferes with the heart's ability to maintain stable heart rhythms and to expand and contract forcefully to pump blood.