Sentences with phrase «forms fibrils»

In view of the fact that the beta - amyloid protein that forms fibrils in Alzheimer's disease is toxic to neurons, we have investigated whether amylin fibrils could be toxic to pancreatic islet cells.

Thus far, each one has proved capable of forming fibrils when heated or immersed in a solution containing acid or a form of alcohol.

This was the first time this technology has been used on amyloid fibrils of the infectious prion, which are a special form of clumped - together proteins that form fibrils.

In close collaboration with his TUM colleagues Johannes Buchner, professor of biotechnology and Sevil Weinkauf, professor of electron microscopy, Reif determined that the small heat shock protein uses a specific non-polar beta - sheet structure pile in its center for interactions with the beta - amyloid, allowing it to access the aggregation process in two locations at once: For one it attaches to individual dissolved beta - amyloids, preventing them from forming fibrils.

Using microscopy, Tanzi, Moir, and their colleagues observed that amyloid - β formed fibrils and trapped C. albicans cells in the guts of infected worms.

Not exact matches

Co-lead researcher, Australian National University Professor John Carver, said that two unrelated proteins aggregate in UHT milk over a period of months to form clusters called amyloid fibrils, which cause the milk to transform from a liquid into a gel.

«When a myocilin propellor misfolds, it unravels and forms amyloid fibrils (stringy abnormal proteins) that kill cells that maintain the trabecular network,» Lieberman said.

Chris Dobson, a chemist and structural biologist at the University of Cambridge, U.K., suspected that a much broader range of proteins could form amyloid fibrils in test tubes.

Materials scientist Robert Haddon has demonstrated that the bone - forming mineral hydroxyapatite will grow around a nanotube scaffold, replacing the collagen fibrils that grow naturally.

About 20 proteins share the ability to clump together to form distinctive «amyloid fibrils» that contribute to Alzheimer's, Creutzfeldt - Jakob disease, and a variety of lesser - known disorders.

An earlier study indicated that the intermediate step was likely a floppy loop area formed by proteins, which didn't seem compatible with the tough, damaging fibril as an end result.

The final β - sheets bind together and stack up to form the damaging fibrils.

Such fibrils form plaques, or areas of tissue damage, that researchers can observe with microscopes.

And since the fibrils they form when misfolded are strong, scientists believe that hope primarily lies not in dismantling them, but in heading off the folding errors.

More than 40 illnesses known as amyloid diseases — Alzheimer's, Parkinson's and rheumatoid arthritis are a few — are linked to the buildup of proteins after they have transformed from their normally folded, biologically active forms to abnormally folded, grouped deposits called fibrils or plaques.

Chief among the fibril forming collagens, type - I collagen gives many soft tissues strength and structure.

To do so, they engineered a collection of 20 DNA double helices to form a nanotube big enough (15 to 20 nanometers — just over one - billionth of a meter — in diameter) to house the fibrils.

«Fibrils are remarkably strong and, as such, are a good barometer for this method's ability to form two - dimensional structures,» observes Seeman.

In the past, he said, much research on Alzheimer's and similar disease focused on fibrils, large bundles of misfolded proteins that form in the brain.

Elongated fibres (fibrils) of the beta - amyloid protein form the typical senile plaques present in the brains of patients with Alzheimer's disease.

However, fibrils are elongated structures that adhere to each other and neither form crystals, nor can be dissolved in water.

This peptide, 39 to 42 amino acids long, is toxic to nerve cells and is able to form elongated fibrils.

Further immunological examinations show that the investigated form of the fibrils is especially relevant to the illness.

«NMR enabled us to obtain additional information such as which amino acid residues form salt bridges thus enhancing the stability of the fibrils,» explains Prof. Henrike Heise from Heinrich Heine University Düsseldorf and Jülich's Biomolecular NMR Center.

Tau and Mcc were induced to form amyloid aggregates by incubation in buffer, and amyloid fibril formation was characterized by ThT and transmission electron microscopy (Fig.

And that sequence can form long chains called oligomers as well as fibers called fibrils.

Amyloid - β 42 (Aβ42) has a strong ability to oligomerize to form diffusible oligomers as well as larger polymers called fibrils that form insoluble amyloid plaques, a major hallmark of AD.

Four of the mAbs, 2T5C9, 2G9C, T1F11, and TB2H7, demonstrated diagnostic potential in enzyme - linked immunosorbent assays (ELISA) by their low to sub-nanomolar cross-reactivity with recombinant wild - type (WT) and mutant TTR aggregates and lack of binding to native TTR or amyloid fibrils formed by other peptides or proteins.

To address this, we have generated 22 monoclonal antibodies (mAbs) against aggregates formed by a blood transport protein, transthyretin (TTR), which primarily forms amyloid fibrils in a patient's heart and / or peripheral nerves.

This toxicity is mediated by the fibrillar form of the amylin peptide and requires direct contact of the fibrils with the cell surface.

The mutant form, though, forms amyloid fibrils, as many proteins will do under the right (wrong?)

In recent years, scientists made the surprising discovery that seminal fluid harbors fragments of proteins that clump together, forming structures called amyloid fibrils.

Clumps that form from these disease proteins are composed of sticky fibrils that damage nerve cells.

They found that abnormal clumps of α - Syn formed by small fibrils act as «seeds» that induce normal α - Syn molecules to misfold and form aggregates.

The basic building blocks of bone are collagen fibrils that form a latticework for deposition of calcium phosphate and other minerals.