Sentences with phrase «forms of amyloidosis»

The company's antibody - based product candidates target a number of potential indications including AL and AA forms of amyloidosis, Parkinson's disease and other related synucleinopathies and novel cell adhesion targets involved in inflammatory diseases and cancers.

Not exact matches

The gene - silencing strategy, in the form of RNA interference, has also showed promise against an uncommon neurodegenerative disease called hereditary ATTR amyloidosis, as my colleague Sy Mukherjee wrote about in Fortune's year - end Investor's Guide.

Patisiran and the subcutaneously administered form ALN - TTRsc02 are being developed for the treatment of hereditary ATTR amyloidosis.

The researchers also examined skin slices from two patients with another form of nerve disease called AL amyloidosis, caused by a bone marrow disorder.

Indeed, a series of recent, exciting studies have shown that the pathologic hallmarks of various PMDs, including Alzheimer's, Parkinson's, Huntington's diseases, and some forms of systemic amyloidosis, can be induced under experimental conditions by administration of tissue homogenates carrying the respective misfolded proteins (Xing et al., 2001; Lundmark et al., 2002; Meyer - Luehmann et al., 2006; Clavaguera et al., 2009; Ren et al., 2009; Eisele et al., 2010; Grad et al., 2011; Luk et al., 2012; Morales et al., 2012; Mougenot et al., 2012; Stöhr et al., 2012; Iba et al., 2013).

The nature of those plaques finally came into focus in 1984, when George Glenner, a research scientist at the University of California, San Diego, identified the peptide called amyloid - beta and hypothesized that Alzheimer's was caused by «amyloidosis» of the brain, a process in which insoluble forms of an amyloid protein accumulate.

While amyloidosis may present itself as a symptom of another medical condition, for those suffering from amyloid disease, the cause will be due to issues within the actual bone marrow whereby abnormal antibodies are produced forming amyloid.