In the new study, Zigmond and colleagues
found damaged nerve cells produce a stream of molecular lures that specifically attract neutrophils to injury sites in mice.
Not exact matches
They also
found AXIN2 in the
damaged nerve cells of adults with multiple sclerosis, a disease in which the immune system attacks myelin.
Specifically, the Mount Sinai study was designed to test whether pharmacological compounds designed to block the function of XPO1 / CRM1 could stop disease progression in mouse models that exhibit some of the characteristics of MS. Researchers
found that two chemical agents (called KPT - 276 and KPT - 350) prevented XPO1 / CRM1 from shuttling cargo out of the nucleus of
nerve cells, which protected them from free radicals and structural
damage.
«Research
findings have implications for regenerating
damaged nerve cells.»
They
found that when SNO modifies PINK1,
nerve cells can not recruit another protein called Parkin to get rid of
damaged mitochondria.
RIPK1, the researchers
found, inflicts
damage by directly attacking the body's myelin production plants —
nerve cells known as oligodendrocytes, which secrete the soft substance, rich in fat and protein that wraps around axons to support their function and shield them from
damage.
Researchers back then
found that exposure to aluminum caused rabbits» brains to develop
nerve cell damage — thought to be a precursor to Alzheimer's at the time — and long - term dialysis patients with high levels of the metal developed dementia.
Two weeks after the rats sustained their injuries, Schwartz's group
found that the number of surviving
cells in the
damaged nerves of these rats was three times higher on average than in rats with similar
damage that received a placebo injection.
A particular type of macrophage known as microglia are
found throughout the brain and spinal cord — in progressive forms of MS, they attack the CNS, causing chronic inflammation and
damage to
nerve cells.
The Sheffield team led by Dr Kurt De Vos and Dr Andy Grierson investigated the role of the C9orf72 protein in
nerve cells and
found it regulates the initiation of a vital process called «autophagy», which helps the
cell to dispose of
damaged proteins and
cell parts, and recycles
cell nutrients.
Whenever it hits the news there's a lot of interest, and recently cannabis
found the spotlight again with videos claiming it can reverse the
nerve cell damage in Huntington's disease.