Sentences with phrase «found decreased expression»

They found decreased expression for almost all of the genes of cholesterol synthesis, including a gene called SREBP - 2, which acts as a master regulator for cholesterol production.

The researchers also looked at the gene expression of skin cells from people with psoriasis and found decreased expression of the genes involved in pigmentation signaling, correlated with increased amounts of IL - 17 and TNF.

However, the impact of the two methylation - regulating enzymes was still seen at 10 to 15 months, when scientists found decreased expression of hundreds of genes — many of which are key tumor suppressor genes such as BMP3, SFRP2 and GATA4 — in the smoke - exposed cells and a five - or - more-fold increase in the signaling of the KRAS oncogene that is known to be mutated in smoking - related lung cancers.

Not exact matches

Our study in an animal model found that influenza infection leads to an increase in the expression of muscle - degrading genes and a decrease in expression of muscle - building genes in skeletal muscles in the legs.

They found that elevated anxious temperament is associated with decreased messenger RNA expression of two neuropeptide Y receptors, Y1R and Y5R, in the central nucleus of the amygdala, a region of the brain that plays an important role in regulating fear and anxiety.

«Our findings explain why mutations that decrease membralin expression would increase the risk for Alzheimer's,» Xu comments.

The researchers» findings indicated that decreased pupil dilation to emotional facial expressions predicted a significant increase in post-flood depressive symptoms, but only among women who experienced higher levels of flood - related stress.

Looking at the mechanism downstream, the researchers found that the loss of Cbf - beta impeded the canonical Wnt signaling pathway, particularly through decreased Wnt10b expression.

Welinder and colleagues found that even though protein expression decreased overall, there were a few select proteins that were drastically elevated during hibernation.

Two mutations that decrease expression of this gene were found in high frequencies in people with the darkest skin.

The mice fed on a low calorie diet were found to experience an extreme increase in NPGL expression, while the 5 - week high - fat - diet group saw a large decrease in NPGL expression.

We found that corticostriatal LTP was decreased in dSPNs, while LTP expression in iSPNs was unchanged.

Then they compared each person's transcriptome to the average transcriptome of people at the same age, intensively exploring about 100 genes whose expression were found to increase or decrease with aging.

Our findings of decreased GYS2, ELOVL6, and FADS1 expression in adipose tissue from patients with diabetes could potentially explain the reduced glucose uptake and impaired ability to store lipids in the adipose tissue of these individuals.

As shown in Fig. 5A, decreased expression of DDX3 at the protein level was found in 73 % of HCC from 26 patients.

(14,15)-RRB- have found age - related satellite cell attrition consistent with the senescence of a subset thereof; moreover, one such study (15) reported that decreases in the number and quality of satellite cells with aging are reliably associated with elevated expression of p16Ink4a (contrary to (14)-RRB-, and with secretory and proteomic abnormalities consistent with a rising burden of senescent cells.

They found a combination that did just that — increased expression of PDI1, decreased expression of MNN9, and deletion of PMR1 led to the highest yield of EGII.

The authors looked at gene expression in a panel of 50 ERBB2 (Her2) positive breast tumors and found that this pattern held up: DNA hypomethylation is associated with decreased gene expression in breast cancer.

Notably, a decrease in p - AKT was also found after silencing mTOR gene expression (B).

We found that depletion of ABL kinases in breast cancer cells decreased STAT5A mRNA expression (Fig. 6D) without decreasing total STAT5 protein abundance as measured by Western blotting with antibodies that detect both STAT5A and STAT5B (Fig. 7D and fig.

In addition to inhibiting STAT5 signaling, we found that depletion of ABL kinases decreased the expression of the Hippo pathway mediator TAZ and downstream target genes in triple - negative and HER2 + breast cancer cells.

We found that 180 genes showed significantly decreased expression and 40 genes showed significantly increased expression in ABL1 / ABL2 knockdown cells (fig.

When they also looked for human genes with significantly higher or lower expression levels, they found 14 genes with increased expression and five with decreased expression.

Using a TCGA data set with 971 invasive breast cancer patients, we found that patients with alterations in the expression of ABL2 and eight validated downstream targets (TAZ, AXL, CTGF, STAT5A, STAT5B, TNC, IL6, and MMP1) exhibited decreased disease - free survival (Fig. 8A).

We found that ~ 90 % knockdown of ABL1 alone resulted in enhanced ABL2 expression and did not produce a significant decrease in the phosphorylation of CrkL, a reporter for the activation state of the ABL kinases (Fig. 2K), and did not inhibit metastasis (Fig. 2, L and M).

We found that a gene signature consisting of 273 genes important for breast cancer bone metastasis showed decreased expression in ABL1 / ABL2 knockdown cells (Fig. 6B)(38).

Although we found that manipulating GBP2 expression accounts for most of the alterations in body size in response to decreased TOR signaling, GBP1 also appears to play a role since knocking down both peptides induces stronger size reductions.

We found that inactivation of the ABL kinases in breast cancer cells also decreased STAT5A mRNA and downstream expression of STAT5 target genes, including TNC (Fig. 6D).

The scientists removed the gene region containing the risk variant from the mouse genome, and found that as a result the mice were healthy but displayed a small decrease in the expression of a nearby cancer gene, called MYC.

We found that alcohol feeding resulted in decreased expression of bactericidal c - type lectins Reg3b and Reg3g.

PTC's GEMS technology exploits the regulatory mechanisms found in the untranslated regions of messenger RNA for the identification of small - molecule drugs that can treat diseases by selectively increasing or decreasing the expression of key proteins by modulating post-transcriptional mechanisms.

Interestingly, BDNF expression was found to be regulated by FNDC5 in a cell - autonomous manner, and recombinant BDNF treatment led to the decreased expression of FNDC5 as part of a negative feedback loop.

In rodent models of T1D induced by streptozotocin, it was found that THC mitigated the severity of the immune response, transiently prevented hyperglycemia and loss of pancreatic insulin, and decreased expression of pro-inflammatory elements including CD3 + T cells, IL - 12, IFN - γ and TNF - α (50).

The researchers found that SIRT1 and SIRT6 expression decreased and that SIRT4 expression increased within 3 - 5 hours after the meal.

Several investigations found that conduct problems coupled with low levels of CU traits are associated with increased amygdala reactivity to fearful and angry facial expressions (Viding et al., 2012; Hyde et al., 2013; Blair et al., 2014; Sebastian et al., 2014), while those coupled with high levels of CU traits are correlated with decreased amygdala reactivity to emotional stimuli, particularly fearful facial expressions (Odgers et al., 2008; Jones et al., 2009).

As expected, we find that inducing high self - esteem decreases expressions of materialism.