Although
they found genetic drivers in the metastases that originated in the primary tumors, the researchers also found genetic variation between metastases in different organs coming from the same patient.
First Major Gene Mutation for Hereditary Prostate Cancer Found After a 20 - year quest to
find a genetic driver for prostate cancer that strikes men at younger ages and runs in families, researchers have identified a rare, inherited mutation linked to a significantly higher risk of the disease.
Not exact matches
«Intensive DNA sequencing efforts to
find the
genetic «
drivers» of metastasis, which is what kills patients in up to 80 percent of cases, have thus far been disappointing, to say the least,» he said.
The new
finding is the latest evidence supporting a growing precision medicine model of psychiatric disease in which disruptions of certain genes during brain development contribute to a person's risk for multiple psychiatric disorders, with other
genetic or epigenetic
drivers, random developmental events, or environmental influences determining the specific disease an individual develops, said senior author Benjamin Cheyette, MD, PhD, an associate professor of psychiatry and a member of the UCSF Weill Institute for Neurosciences and the Kavli Institute for Fundamental Neuroscience at UCSF.