Not exact matches
An analysis
of 41,302 blood samples taken from the entire study at different time points
found that a child who had an intermediate
antibody level and became infected again had a 7.64 times
higher risk
of being in the small group that developed DHS / DSS, researchers report today in Science.
Antibodies derived from a type of immune cell found in unusually high numbers in HIV - infected individuals with chronically uncontrolled virus levels are less effective at neutralizing HIV than antibodies derived from a different type of immune cell more common in people without HIV, scientis
Antibodies derived from a type
of immune cell
found in unusually
high numbers in HIV - infected individuals with chronically uncontrolled virus
levels are less effective at neutralizing HIV than
antibodies derived from a different type of immune cell more common in people without HIV, scientis
antibodies derived from a different type
of immune cell more common in people without HIV, scientists report.
Specifically, the NIAID team
found that the individuals with
high NA
antibody levels experienced less severe disease, a shorter duration
of viral shedding and symptoms, and fewer and less severe symptoms compared with those with
high HA
levels when challenged with the 2009 H1N1 virus.
As expected, the researchers
found that the group
of participants who had
high levels of anti-HA
antibodies when enrolled in the trial experienced a significantly lower incidence
of mild - to - moderate influenza disease and some reduction in its duration compared with participants with low HA
antibody levels.
Currently, seasonal flu vaccines are designed to induce
high levels of protective
antibodies against hemagglutinin (HA), a protein
found on the surface
of the influenza virus that enables the virus to enter a human cell and initiate infection.
Surprisingly, the researchers
found that participants with
high levels of NA
antibodies experienced a more robust protective effect from the vaccine than did those in the
high HA group.
New research conducted by scientists at the National Institute
of Allergy and Infectious Diseases (NIAID), part
of the National Institutes
of Health,
found that
higher levels of antibody against a different flu surface protein — neuraminidase (NA)-- were the better predictor
of protection against flu infection and its unpleasant side effects.
In addition, the researchers
found that most
of these children have
high levels of potent and broadly neutralizing
antibodies directed against HIV.
The 44 - year - old mother
of two teens had developed
high levels of antibodies that attack foreign tissue, causing a positive crossmatch, which made
finding a compatible donor for her nearly impossible.
The study, published in the Inflammatory Bowel Disease Journal, evaluated the
levels of infliximab, an
antibody designed to bind to and block the effects
of TNF - alpha, an inflammatory protein
found in
high levels in patients with IBD, such as Crohn's disease and ulcerative colitis, and numerous other inflammatory conditions such as rheumatoid arthritis and psoriasis.
They had only blood serum available, which is not a good starting material, Koopmans says, and besides, once an animal has
high levels of antibodies, «you don't expect much luck in
finding the virus.»
Similar to
findings regarding anti-HA head
antibodies, they
found that participants with
higher baseline
levels of anti-HA stem
antibodies had reduced viral shedding, but no significant reduction in the duration or severity
of illness.
The
findings also suggest that a substantial degree
of protection can be achieved against stringent virus challenges, even in the absence
of high levels of tier 2 neutralizing
antibodies.
The
findings were published In the New England Journal
of Medicine (NEJM) and concluded that vaccines designed to induce
higher levels of V1V2
antibodies and lower Env - specifc IgA
antibodies could result in improved efficacy against HIV - 1 infection.
Researchers from Imperial College London and University College London have
found that people who have
higher levels of IgG
antibodies in their blood have a lower overall risk
of heart attack.
A recent U.K. study
found that, compared with folks who got immunized between 3 p.m. and 5 p.m., people who received shots between 9 a.m. and 11 a.m. had significantly
higher levels of the
antibodies for two flu strains one month later.
A Journal
of the American Medical Association study
found higher levels of EBV
antibodies in people with MS. (About 90 percent
of people are infected with EBV at some point, although not all get symptoms.)
Potentially more powerful was the
finding that cats in the treatment group had a
higher level of an important
antibody.
A single test
finding of Leptospira
antibody, even if the blood
level (titer) is
high, may not mean that the dog has Leptospirosis because infection with less harmful serovars can still result in
high antibody.