Sentences with phrase «found higher levels of expression»

Researchers also found higher levels of expression of the gene MET, which is linked to autism spectrum disorder, in the human prefrontal cortex compared to the other primates tested.

Not exact matches

The researchers» findings indicated that decreased pupil dilation to emotional facial expressions predicted a significant increase in post-flood depressive symptoms, but only among women who experienced higher levels of flood - related stress.

They found higher levels of JAK1 in resistant tumors, which caused increased expression of epidermal growth factor receptor (EGFR)-- a receptor tyrosine kinase that promotes cell proliferation.

Through analyzing several datasets of prostate cancer cases and patient outcomes, the researchers found that a high level of expression of two genes, TOP2A and EZH2, was associated with early recurrence of prostate cancer and metastatic spread, leading to an increased risk of death.

«The high level of CIRPB expression found in the developing ovaries of marine turtle hatchlings and post-hatchlings also supports our hypothesis that CIRBP may play a role in the molecular pathways of sexual differentiation in marine turtles,» said Tezak.

Using this approach, these investigators found that nodes (genes) with high connectivity tend to have lower levels of change in expression than peripheral nodes, consistent with the notion that disease ‐ causing genes are typically not central hubs in a molecular module.

The highest level of expression was found in heart and bladder endothelial cells.

If, for instance, a researcher finds that dozens of genes in a microarray are differentially expressed on a high - fat purified ingredient diet compared to a low - fat GB diet, it is tempting to conclude that gene expression was altered due to the differences in fat levels between the diets.

In the 1980s, Dr. Kaufman's experience with gene transfer and engineering led him to become a founding scientist at Genetics Institute Inc., where he engineered mammalian cells for high - level expression of therapeutic proteins, such as clotting factors that are now used to treat individuals with hemophilia.

However, when we extracted gene expression levels from the brain transcriptome data following the methodology in Carneiro et al. [29], we found that levels of nucleotide diversity and the proportion of low frequency variants between lowly (bottom 5 %) and highly (top 5 %) expressed genes in our dataset (Table S7) were not significantly different in most comparisons (with the exception of π in O. c. cuniculus) nor did they consistently differ in the expected direction when assuming higher error rates in lowly expressed genes.

By utilizing paired genome - wide high - throughput DNA sequencing (DNA - seq) with RNA - seq, we found that gene dosage, at the level of individual genes or chromosomal «somy» (a general term covering disomy, trisomy, tetrasomy, etc.), accounted for greater than 85 % of total gene expression variation in genes with a 2-fold or greater change in expression.

This gradient of surface antigen expression was paralleled by a gradient in expression of pluripotency genes, with highest levels of genes like Oct - 4 found in the population of cells with the highest level of antigen expression.

Examining expression levels of H2AX in breast cancer tumor data from The Cancer Genome Atlas, a large National Institutes of Health database containing genetic information about tumor tissue from more than 11,000 patients, the Roswell Park team found that breast cancer patients whose tumors had high levels of H2AX had a significantly worse prognosis than those with low levels.

In multiple independent breast cancer cohorts analyzed, we found a strong association of high expression levels of MELK with a higher grade of malignancy and an unfavorable prognosis regardless of the treatment modality.

High levels of gene expression were found in both strains for genes involved in growth, energy and respiration (e.g., ribosomal proteins, ATP synthase, pseudoazurin), and the C - 1 metabolic carbon such as methanol dehydrogenase, ribulose monophosphate enzymes (D - arabino -3-hexulose 6 - phosphate formaldehyde - lyase, 6 - phospho -3-hexuloisomerase), formaldehyde activating enzymes (Data S6, Fig.

With filmmakers such as Coogler and Johnson — alongside Jenkins, Waititi and other creators of handcrafted blockbusters — blazing a trail, hopefully more filmmakers will find a way to satisfy the needs of the system while also building vehicles for personal expression and achievement of craft at the highest levels.

The study also found that higher levels of spousal gratitude expressions protected men's and women's divorce proneness as well as women's marital commitment from the negative effects of poor communication during conflict.

We found that levels of physical aggression were significantly higher in men who had experienced traumatic events during the first 15 years of life and who carried the low expression allele (MAOA - L).

Several investigations found that conduct problems coupled with low levels of CU traits are associated with increased amygdala reactivity to fearful and angry facial expressions (Viding et al., 2012; Hyde et al., 2013; Blair et al., 2014; Sebastian et al., 2014), while those coupled with high levels of CU traits are correlated with decreased amygdala reactivity to emotional stimuli, particularly fearful facial expressions (Odgers et al., 2008; Jones et al., 2009).

The findings from these studies converge to suggest that the mothers of children with high levels of CU traits have a more negative emotion socialization style, characterized by less acceptance and more dismissing of children's experience and expression of emotions.

Studies investigating the effects of CU traits on facial emotion recognition have also yielded mixed findings, with some studies showing that CU traits are associated with deficits in recognizing facial expressions signalling distress (i.e., fear and sadness; Dadds et al. 2008; Fairchild et al. 2009, 2010), whilst other studies have reported superior fear recognition in those with high versus low levels of CU traits (e.g., Woodworth and Waschbusch 2008).