Sentences with phrase «found in a single gene»

Could the solution be found in a single gene, asks Bob Holmes

I think that the cure for schizophrenia can be found in a single gene.

Not exact matches

In 1986 my research group at the Rockefeller University and another led by Jeffrey Hall of Brandeis University and Michael Rosbash of the Howard Hughes Medical Institute at Brandeis found that the three mutant flies had three different alterations in a single gene named period, or per, which each of our teams had independently isolated two years earlieIn 1986 my research group at the Rockefeller University and another led by Jeffrey Hall of Brandeis University and Michael Rosbash of the Howard Hughes Medical Institute at Brandeis found that the three mutant flies had three different alterations in a single gene named period, or per, which each of our teams had independently isolated two years earliein a single gene named period, or per, which each of our teams had independently isolated two years earlier.

In yeast, for example, they've found that increasing the activity of a single gene, called Sir2, can significantly extend life span.

The researchers determined that CRISPR had successfully corrected a gene that causes blindness, but Kellie Schaefer, a PhD student in the lab of Vinit Mahajan, MD, PhD, associate professor of ophthalmology at Stanford University, and co-author of the study, found that the genomes of two independent gene therapy recipients had sustained more than 1,500 single - nucleotide mutations and more than 100 larger deletions and insertions.

Working with this hypothesis, the researchers conducted a statistical analysis of the CX3CR1 gene in over 7000 schizophrenia and autism patients and healthy subjects, finding one mutant candidate, a single amino acid switch from alanine to threonine, as a candidate marker for prediction.

After gene - typing about 3,000 people, Sturm found that how OCA2 is expressed — and how much pigment a person has — is strongly linked to three single nucleotide polymorphisms (SNPs), or single letter variations, in a DNA sequence near the OCA2 gene.

The two studies together suggest that single copies of inactivating ANGPTL3 mutations are found in roughly one of every 250 people of European descent, whereas people with mutations in both copies of the gene — as in the family studied by Musunuru and colleagues — are much rarer.

Reviewing thousands of genome wide associate studies (GWAS) to identify genetic variants in single nucleotide polymorphisms (SNPs), investigators at Dartmouth's Norris Cotton Cancer Center found that some alleles (one of a pair of genes located on a specific chromosome) are more frequently risk - associated with disease than protective.

Mitochondria carry only a few genes, but they are so plentiful that it's often easier to find their DNA than the single full human genome in a cell's nucleus.

Harvard Medical School researcher Melina Claussnitzer and her team found that a single variation in the FTO gene caused fat cells that would normally become healthier beige to turn into white fat cells instead.

The team found that a mutation in a single pair of nucleotides in the gene causes seed coat permeability — that is, a change in one pair out of the approximately 1 billion base pairs that make up the soybean genome.

However, cancer cells may instead be coaxed to turn back into normal tissue simply by reactivating a single gene, according to a study that found that restoring normal levels of a human colorectal cancer gene in mice stopped tumor growth and re-established normal intestinal function within only 4 days.

«It's important they've found this gene, but it took a sample of 20,000 people to find it, precisely because the effect is so small,» says Robert Plomin at the Institute of Psychiatry in London, and lead author of a groundbreaking study in 2007 which failed to find any single genes of disproportionate importance in intelligence.

The researchers found that the blond hair commonly seen in Northern Europeans is caused by a single change in the DNA that regulates the expression of a gene that encodes a protein called KITLG, also known as stem cell factor.

Yet for years biologists could not find a single gene involved in language.

Pinker says that the findings are a first step in demonstrating that intelligence relies on large numbers of genes, each with a tiny effect, rather than on single genes that have moderate or large effects, but which are so rare that none has yet been identified.

«Single gene encourages growth of intestinal stem cells, supporting «niche» cells, and cancer: Finding in mice could lead to new therapies for damaged organs, cancer.»

There is little dispute that genetics accounts for a large amount of the variation in people's intelligence, but studies have consistently failed to find any single genes that have a substantial impact.

Although the gene sequences were not identical to the Mikovits - Ruscetti XMRV gene sequence reported in Science, they were so close Lo believed he had found genetic variants of a single MLV - like virus species that likely included XMRV.

They found a single mutation in the ADGRE2 gene shared by family members with vibratory urticaria but not present in unaffected people.

The team found that adding in a single extra copy of gene that expresses Maf1 decreased stored lipids by 34 percent, while reducing Maf1 levels increased stored lipids by 94 percent.

With the completion of the first phase of the Human Genome Project in 2000, and the advent of sequencing technologies that can detect gene variations such as single nucleotide polymorphisms (SNPs), for the first time scientists have the tools in hand to find the key immune genes and genetic networks that play roles in vaccine response.

The team found that a single polymorphism (a difference in one «letter» of the sequence) in the BDNF gene accounted for significant differences in intelligence among those with similar injuries and comparable intelligence before being injured.

«We report here a gene therapy dose - finding study in a large animal model of a severe muscle disease where a single treatment resulted in dramatic rescue,» said Childers.

They found up to seven variations of the gene — some differing by as much as 25 % of their base pairs — in a single snail.

They found a point mutation in the gene (a single altered base pair) in one of 91 randomly selected short individuals, and no such mutations in 300 people of average height — suggesting that about 1 % of all short people may carry a SHOX mutation.

«The bad news about our finding is that it shows that resistance can arise through single mutations in one gene and pop up anywhere, at any time,» Dr. Fidock says.

An alteration in the neuregulin - 1 gene — a single change in one letter of the DNA code for the protein — has been found in families with schizophrenia and linked to late - onset Alzheimer's disease with psychosis.

The researchers, led by Dr Charles Wondji, used a wide range of methods to narrow down how the resistance works, finding a single mutation in the GSTe2 gene, which makes insects break down DDT so it's no longer toxic.

Beyond offering further proof that single genes can have dramatic influences on longevity, an idea that drew skepticism just a decade ago, the new finding may help scientists explain how severely reducing calorie intake extends life span in a variety of animals (SN: 11/25/00, p. 341: Low - cal diet may reduce cancer in monkeys).

A recently published study from two Iowa State University scientists shows that a gene found only in a single plant species can increase protein content when introduced into staple crops.

Now, a study led by a researcher at the Salk Institute has found that variants of a single gene can largely determine a plant's ability to thrive in environments where iron is scarce.

A second major finding of the new study, which analyzes the genomes of over 2,500 «simplex» families — those in which a single child but neither parent nor siblings, if any, have ASD — is that the pool of spontaneously mutated genes contributing to ASD across the population totals about 400.

«This is an important finding that will help future researchers, and eventually physicians, to maximize the effectiveness of gene therapy for curtailing sensory deficits associated with USH3 syndrome and, perhaps, in other disorders linked to defects in single genes,» said Alagramam.

The team also compared the 7442 genes found as single copies in both the cobra and the python with the same genes in all other land vertebrates sequenced so far.

In the years after finding the CFTR gene at the root of the disease, Collins, Tsui and others discovered the situation was far more complex than they had ever dreamed: Instead of just a single mutation in the gene, researchers found some 1,900 distinct mutationIn the years after finding the CFTR gene at the root of the disease, Collins, Tsui and others discovered the situation was far more complex than they had ever dreamed: Instead of just a single mutation in the gene, researchers found some 1,900 distinct mutationin the gene, researchers found some 1,900 distinct mutations.

Nonetheless, not a single life - extending gene has been found in the human genome yet.

Your feelings about brussels sprouts could come down to a single gene: Researchers at the University of Connecticut found that people missing the receptor for a bitter chemical called PROP tend to like veggies rich in the compound.

Ruffled genes Burke was part of a team that, in 1995, found that the different approaches of male ruffs were caused by a single inherited factor.

The authors find that evolved differences in UV absorbance between the species could be explained by changes to a single gene, MYB - FL.

In a study, published in Science, they investigated a gene region that contains a particular single nucleotide variant associated with increased risk for developing colorectal and prostate cancers — and found that removing this region caused dramatic resistance to tumor formatioIn a study, published in Science, they investigated a gene region that contains a particular single nucleotide variant associated with increased risk for developing colorectal and prostate cancers — and found that removing this region caused dramatic resistance to tumor formatioin Science, they investigated a gene region that contains a particular single nucleotide variant associated with increased risk for developing colorectal and prostate cancers — and found that removing this region caused dramatic resistance to tumor formation.

The investigators found that people who carry a single copy of the KL - VS variant of the KLOTHO gene, roughly 20 percent of the population, have more klotho protein in their blood than non-carriers.

«Trying to find a single causative gene for diseases with a complex genetic background is like looking for the proverbial needle in a haystack,» says Lea Davis, PhD, of the section of Genetic Medicine at the University of Chicago, co-corresponding author of the PLOS Genetics report.

Two genes critical to the immune system's adaptability in battling viruses, bacteria and other invaders receive on and off signals from a single DNA segment, HHMI researchers have found.

In findings appearing online today in Cell Stem Cell, researchers in the laboratory of Gladstone Investigator Yadong Huang, MD, PhD, describe how they transferred a single gene called Sox2 into both mouse and human skin cellIn findings appearing online today in Cell Stem Cell, researchers in the laboratory of Gladstone Investigator Yadong Huang, MD, PhD, describe how they transferred a single gene called Sox2 into both mouse and human skin cellin Cell Stem Cell, researchers in the laboratory of Gladstone Investigator Yadong Huang, MD, PhD, describe how they transferred a single gene called Sox2 into both mouse and human skin cellin the laboratory of Gladstone Investigator Yadong Huang, MD, PhD, describe how they transferred a single gene called Sox2 into both mouse and human skin cells.

For the 374 expressed genes, we find many regions with statistically significant association of single nucleotide polymorphisms (SNPs) with expression variation in lymphoblastoid cell lines after correcting for multiple tests.

July 3, 2013 New mechanism for human gene expression discovered In a study that could change the way scientists view the process of protein production in humans, University of Chicago researchers have found a single gene that encodes two separate proteins from the same sequence of messenger RNIn a study that could change the way scientists view the process of protein production in humans, University of Chicago researchers have found a single gene that encodes two separate proteins from the same sequence of messenger RNin humans, University of Chicago researchers have found a single gene that encodes two separate proteins from the same sequence of messenger RNA.

As an example, skeletal malformations and dysplasias, often detected through routine prenatal ultrasound examination, constitute a phenotypic finding in more than 300 syndromic and non-syndromic disorders and their genetic etiology may be due to a wide variety of genetic aberrations, ranging from copy number variations to single gene mutations.

A single disabling change — an alteration of one nucleotide — was found in the TRAPPC9 gene in all three girls.