Sentences with phrase «found in human patients»

The changes also resemble those found in human patients with hippocampal damage.

Not exact matches

Sequencing in one 18 - year - old patient found several oncogenes, and her and her family will continue to work with Human Longevity to monitor the cells.

When this belief was coupled with the notion of a last judgement which would not occur until God «had accomplished the number of his elect», in words from still another prayer, it said something about the corporate nature of human life, the equally corporate nature of whatever destiny men have, and the need for patient waiting until our fellowmen have found their capacity for fulfillment along with us.

Although more and more human studies are being conducted to validate claims found in animals, many studies are with patients with a certain illness or condition (ex.

To better understand their findings, the team examined the animal model for APS1 (i.e. mice with the same genetic defect as human patients with the syndrome) and found that male mice spontaneously developed an inflammatory disease in their prostate glands — a so - called prostatitis — and reacted to transglutaminase 4.

Ubogu says the findings are very exciting, as they provide knowledge of leukocyte trafficking in human nerves, but more work needs to be done in affected patients to develop an effective drug.

But the new test found another seven, including a respiratory virus called human adenovirus B type 3A, which usually is harmless but can cause severe infections in some patients.

Bolton combined these human hearing models with model checking (an automated, computational approach for finding problems in complex systems) to assess masking in a common patient - monitoring device with six different alarms.

If further research confirms the findings in human cells, limiting the amount of asparagine cancer patients ingest could be a potential strategy to augment existing therapies and to prevent the spread of breast cancer, Knott added.

Specifically, rodents genetically modified to express human amyloid precursor protein (hAPP), which can lead to the debilitating plaques that form in the brains of Alzheimer's patients, seem to struggle to find the hidden platform relative to their healthy peers.

This is the finding of a study in both mice and human patients led by researchers at NYU Langone Medical Center and published online June 9 in the journal Cell.

Scientists have found a variation of the miR - 182 gene in patients with primary open - angle glaucoma that results in this overexpression, said Dr. Yutao Liu, vision scientist and human geneticist in the Department of Cellular Biology and Anatomy at the Medical College of Georgia at Augusta University.

The finding, reported in next month's issue of Nature Medicine, raises new questions about whether people could contract exotic diseases if animal organs become routinely transplanted into human patients.

The common pathway found in mouse models was also found in human tumors, suggesting that resistance could indeed be blocked in patients with the same drug as in mice.

They found out that TiY is capable of distinguishing TICs from non-TICs in various human lung cancer cell lines and patient - derived lung tumors.

They found that, within the first three days of injury, fish in the concussion group were slower to find a school of fish with which they previously swam, a measure of spatial memory which is impaired in other animal models of concussion and human patients.

If the findings hold true in humans, rapamycin could provide considerable benefits to spinal cord injury patients, up to 80 percent of whom experience clinically significant pain that is described as burning, stabbing, and electric shock - like.

The human UFD1L gene was deleted in all 182 patients studied with 22q11 deletion, and a smaller deletion of approximately 20 kilobases that removed exons 1 to 3 ofUFD1L was found in one individual with features typical of 22q11 deletion syndrome.

«Next steps are to further explore this possibility in human trials in order to assess if it will help patients, but these two drugs make sense from a variety of studies and we find that they act together through multiple mechanisms to control cancer growth in the laboratory.»

«These results are especially exciting because they show that we can take findings in the mouse and possibly apply them at the human patient population,» said Koenig.

«Function of olfactory receptor in the human heart identified: The new findings may be relevant in the long term for diabetic patients and patients with increased heart rates.»

They also found elevated granzyme A levels in blood samples taken from non-human primates infected with chikungunya, as well as from human chikungunya patients.

«By analyzing mice with the WNT10A mutation, as well as tissues from human patients with WNT10A mutations, we found that WNT10A regulates the proliferation, but not the maintenance, of stem cells in hair follicles,» said Sarah Millar, PhD, vice chair for Basic Research in the Department of Dermatology.

University of Alabama at Birmingham researchers have found that amounts of this microRNA are significantly elevated in the brains of experimental rats with induced depression from corticosterone treatment, in the post-death brains of humans diagnosed with MDD and in peripheral blood serum from living patients with MDD, according to a study by led by Yogesh Dwivedi, Ph.D., the Elesabeth Ridgely Shook Endowed Professor and director of Translational Research, UAB Mood Disorders Program, Department of Psychiatry.

In the years after the visit, his foundation granted about $ 4 million to Edgerton's lab to find a way to train human patients with complete spinal cord injuries to walk again.

For example, although early clinical trials of Listeria - based vaccines have shown that the neutralized bacterium produces only mild flulike symptoms in human patients with cervical cancer, the various methods of genetically disarming the bacteria should be explored to find the safest approach for people gravely ill with pancreatic cancer, because these patients are likely to already have weak immune systems.

Though the findings were made in mice, not humans, the researchers say the crucial role of calcium may help explain another mystery: Why some hospital patients and nursing home residents have a much higher risk of contracting C. diff infections and the resulting diarrhea that carries its spores out of the body.

Their findings, reported in Nature Communications, may shed light on human lung disease, in particular, the mechanism behind non-familial pulmonary hypertension in patients with conditions such as emphysema and pulmonary fibrosis.

That finding indicates that very low numbers of the cells in the body could be enough to protect human patients from maladies ranging from infections to cancer.

«Artificial sweetener could intensify symptoms in those with Crohn's disease: Promotes «bad» bacteria and intestinal inflammation; findings may guide dietary habits in human patients.»

Identical findings were seen in human patients with traumatic complete spinal cord injury, researchers wrote.

«We found that a comprehensive exercise and diet program in a group setting can make a difference for prostate cancer patients, and the difference was greater than I expected in a short period of time,» said lead author Brian Focht, a professor of human sciences at Ohio State.

When they looked at their human patients, they found that all had mutations in the SELENBP1 gene that produces this protein and they all had high levels of methanethiol and dimethyl sulfide in their blood.

The existence of cancer stem cells has already been reported in a number of human cancers, explains Professor Jacobsen, but previous findings have remained controversial since the lab tests used to establish the identity of cancer stem cells have been shown to be unreliable and, in any case, do not reflect the «real situation» in an intact tumour in a patient.

Researchers from Uppsala University, Sweden, and the Broad Institute, USA, have identified both similarities and differences between a single tumor type in multiple dogs breeds; a finding they believe parallels the situation in the cancer of human patients.

Further testing found these mice had lower - than - expected growth hormone and insulin - like growth factor (IGF1) levels in the blood, potentially explaining the small stature and delayed development seen in human patients.

If borne out in humans, the findings caution against giving this type of antioxidant - containing medication to diabetic cancer patients.

«Fasting blood sugar is easily measured and our findings suggest that it could serve as a useful measure in advising some patients on the type of diet that is most beneficial for their weight loss,» said senior author Sai Krupa Das, Ph.D., scientist in the Energy Metabolism Laboratory at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University in Boston.

Although the retinopathy in mice is exaggerated compared to human HD patients, the finding is partly in line with patient data showing impaired color vision but no clear - cut anatomical retinopathy.

The researchers next showed that the Smurf1 gene controls M. tuberculosis growth in human macrophages and that the Smurf1 protein was found in association with bacteria in the lungs of patients with tuberculosis infections.

The researchers also found that IL - 33 levels are increased in the retinas of AMD patients, suggesting that the same pathway may occur in humans.

After confirming in mouse models that cells from HER2 - positive breast cancers became resistant to anti-HER2 treatment when implanted into the brain but not into other tissues, the investigators found that HER3 is overexpressed in brain metastases of HER2 - positive breast cancers from both mice and human patients.

Findings made in animal models do not always translate to patients, but it appears that this important eye vessel functions very similarly in mice and humans.

The next step, Datta says, is to find which fragments of the human histones trigger lupus, then test whether injecting high doses in patients will help them.

They analyzed a large cohort of human patient samples from the human kidney biobank managed by Susztak and found that the interconversion might also occur in patients with kidney disease and likely contributes to a condition when the kidneys can not remove enough acid from the body.

Liv Bode, a virologist at the Robert Koch Institut in Berlin whose team was the first to isolate the virus from patients, welcomes the findings as a «solid piece of work that fits the picture and lends further support to the existence of human [strains of] BDV.»

Beilhack and colleagues found that a slightly modified version of STAR2 has a similar effect on human T reg cells, suggesting that the approach could also prevent GvHD in leukemia and lymphoma patients after bone marrow or hematopoietic stem cell transplants.

«If we could find human rheumatoid arthritis patients carrying a defect in degrading DNA in macrophages, a new treatment would be developed,» says Nagata.

The next step was to find out which role Shp2 and its target genes play in human patients with breast cancer.

Guselkumab, a fully human monoclonal antibody targeting IL - 23, in this Phase 2 study for the treatment of PsA, was well tolerated with no unexpected safety findings in this patient population.2 Guselkumab is now being pursued in a Phase 3 development programme for psoriatic arthritis.