Sentences with phrase «found in normal mice»

Some fell into a pattern of two to three separate cycles of sleep and activity per day, in contrast to the single daily cycle found in normal mice, while others» rhythms were completely disorganized, Blackshaw says.

Not exact matches

The team found neonatal mice with the mutations had normal - appearing skin, and the dry itchy skin of dermatitis did not develop until the mice were a few months old, the equivalent of a young adult in human years.

In experiments with mice, the researchers found that Paneth cells engineered to lack a functional ATG16L1 gene were five times more likely to die in the face of rising TNF - alpha signals than normal cellIn experiments with mice, the researchers found that Paneth cells engineered to lack a functional ATG16L1 gene were five times more likely to die in the face of rising TNF - alpha signals than normal cellin the face of rising TNF - alpha signals than normal cells.

But later, Javier Bravo at University College Cork managed to change the behaviour of normal adult mice by feeding them with a probiotic bacterium called Lactobacillus rhamnosus, often found in yoghurts and dairy products.

For this study the researchers targeted very specific types of GABA receptors to improve social behaviors with clonazepam, but the team also found that by using a different drug, they could target other GABA receptors and actually reduce the ability to socially interact in normal mice — underscoring that future medications would need to target very specific receptors so as not to diminish the drug's impacts.

Researchers led by Emory University pathologist Andrew Gewirtz found that mice genetically deficient in an immune system receptor have altered gut bacteria, eat more than normal mice do, and develop features of metabolic syndrome.

Aside from a food intake in laboratory mice that's about 40 percent fewer calories than normal, however, it's been found that another way to activate this pathway is with rapamycin, which appears to have a significant impact even when used late in life.

The researchers found that the tissue made normal connections with surrounding nerves and muscle tissues in the mice, and those connections allowed the tissue to function normally.

In those mice, but not in normal mice, they found that caerulein caused existing alpha cells in the pancreas to differentiate into insulin - producing beta cellIn those mice, but not in normal mice, they found that caerulein caused existing alpha cells in the pancreas to differentiate into insulin - producing beta cellin normal mice, they found that caerulein caused existing alpha cells in the pancreas to differentiate into insulin - producing beta cellin the pancreas to differentiate into insulin - producing beta cells.

When «depressed» mice and rats were given ketamine, the number of bursting cells was much lower, similar to the number in normal animals, Hu's team found.

The study compared intestinal wound healing in two groups of mice: 1) typical mice (wild type) found in nature and 2) mice genetically deficient in the healing factor IL - 10, specifically in macrophages, which impairs their ability to have normal wound repair.

«The challenge is finding targets that exist on other types of cancer cells but not on normal cells,» says pediatric oncologist Stephan Grupp of the Children's Hospital of Philadelphia, who worked with Porter on testing the treatment in mice.

When the Stanford team measured pyrophosphate levels in cultured cells derived from ank and normal mice, they found that the chemical accumulated in cells from the ank mice but decreased in the culture medium.

In the new study, Ji's group put SHANK3 - deficient mice through a battery of sensory tests, finding that the animals had lower sensitivity than normal mice to heat and heat - related pain — akin to the soreness a person feels after a sunburn.

However, when the researchers knocked out SIRT1 in endothelial cells of 10 - month - old mice, then put them on a four - week treadmill running program, they found that the exercise did not produce the same gains seen in normal 10 - month - old mice on the same training plan.

However, cancer cells may instead be coaxed to turn back into normal tissue simply by reactivating a single gene, according to a study that found that restoring normal levels of a human colorectal cancer gene in mice stopped tumor growth and re-established normal intestinal function within only 4 days.

Using mice in which the production of the enzyme was blocked, the researchers found that mice lacking FIH in their muscles require more oxygen than normal when exercising.

The researchers found that Sp7 in normal mice was expressed only in the dental mesenchymal tissue that gives rise to odontoblasts; it was not expressed in the oral epithelium that gives rise to ameloblasts.

The researchers found that mutant mice lacking Del - 1 had more severe attacks of the EAE than normal mice, with more damage to myelin, the fatty sheath that coats neurons and helps in the transmission of signals along the cell.

When the researchers then induced stroke in mice either with or without the PARP gene, they found that the resulting tissue damage in the mice without the enzyme was 80 % less than in normal mice.

They then injected the protein into elderly mice with normal immune systems, and found this reproduced the beneficial effects of cord plasma on both memory performance and LTP in the hippocampus whereas mice engineered to lack TIMP2 showed reduced LTP.

In an article entitled «Prion protein modulates monoaminergic systems and depressive - like behavior in mice» and published in the Journal of Biological Chemistry, the group shows that mice lacking normal prions show a depressive - like behavior similar to depression symptoms found in patients with Alzheimer's and prion diseases, namely Creutzfeldt - Jakob Disease (CJD), variant Creutzfeldt - Jakob Disease (vCJD), Gerstmann - Sträussler - Scheinker syndrome, Fatal Familial Insomnia and kurIn an article entitled «Prion protein modulates monoaminergic systems and depressive - like behavior in mice» and published in the Journal of Biological Chemistry, the group shows that mice lacking normal prions show a depressive - like behavior similar to depression symptoms found in patients with Alzheimer's and prion diseases, namely Creutzfeldt - Jakob Disease (CJD), variant Creutzfeldt - Jakob Disease (vCJD), Gerstmann - Sträussler - Scheinker syndrome, Fatal Familial Insomnia and kurin mice» and published in the Journal of Biological Chemistry, the group shows that mice lacking normal prions show a depressive - like behavior similar to depression symptoms found in patients with Alzheimer's and prion diseases, namely Creutzfeldt - Jakob Disease (CJD), variant Creutzfeldt - Jakob Disease (vCJD), Gerstmann - Sträussler - Scheinker syndrome, Fatal Familial Insomnia and kurin the Journal of Biological Chemistry, the group shows that mice lacking normal prions show a depressive - like behavior similar to depression symptoms found in patients with Alzheimer's and prion diseases, namely Creutzfeldt - Jakob Disease (CJD), variant Creutzfeldt - Jakob Disease (vCJD), Gerstmann - Sträussler - Scheinker syndrome, Fatal Familial Insomnia and kurin patients with Alzheimer's and prion diseases, namely Creutzfeldt - Jakob Disease (CJD), variant Creutzfeldt - Jakob Disease (vCJD), Gerstmann - Sträussler - Scheinker syndrome, Fatal Familial Insomnia and kuru.

The researchers also administered a compound to normal mice that blocked TRPV4, and found that inhibiting TRPV4 also led to smaller reductions in bite force, similar to the effects of the mice engineered without the Trpv4 gene.

Upon further investigation, the team found that Noxo1 is highly expressed in the embryonic inner ear of normal mice, though its expression drops sharply after birth.

The purple GM tomatoes have already been found to prolong the lives of cancer - prone mice and in the latest findings they also more double the normal shelf life of tomatoes from an average of 21 days to 48 days.

As a result, they have less than half of the fat tissue found in normal, aged mice.

They found that levels of an enzyme involved in ketone metabolism, known as BDH1, were twice as high in mice with both early stage and complete heart failure compared to normal animals.

They found that the mice can develop damage to the optic nerve despite normal pressure in the eye following KPro surgery and identified TNFa and IL - 1 as inflammatory factors involved in this process, with high levels of TNFa mediating the damage to the optic nerve.

The researchers also found that increases in Rev - erbα caused increases in Cx43 concentrations when normal mice were awake.

To overcome this hurdle, researchers genetically engineered human T cells to produce a CAR protein that recognizes a glycopeptide found on various cancer cells but not normal cells, and then demonstrated its effectiveness in mice with leukemia and pancreatic cancer.

The scientists found that transgenic mice in which phospholipase Cγ1 was unlinked from the TrkB receptor were less susceptible to seizures than normal mice.

As the mice developed, Verma's team found that the rodents» brains were only a third of their normal size, with particularly striking reductions in brain areas involved in learning and memory.

The researchers found that levels of a substance called 4 - ethylphenylsulfate that is produced by gut bacteria increased 46-fold in the mice with autistic symptoms, but returned to normal after treatment with B. fragilis.

Although muscle cells did not reduce in size or number in mice lacking a protective antioxidant protein, they were weaker than normal muscle cells, researchers from the Barshop Institute for Longevity and Aging Studies at The University of Texas Health Science Center San Antonio found.

To see what was happening in the brains of these ankyrin - G mutant mice, the researchers analyzed the cell components in inhibitory synapses connecting with pyramidal neurons, finding that two proteins known as GAT1 and GAD67 — responsible for making the neurochemical GABA that dials back nerve impulses — were at much lower levels in the synapses on pyramidal neurons in ankyrin - G mutant mice than in normal mice.

Sagawa and colleagues compared mice whose mothers had received 30 % fewer calories during pregnancy with normal controls and found that the underweight pups experienced a shift in timing: the normal increase in blood leptin a week earlier than usual.

The researchers found that in genetically - modified mice lacking Interferon - 1, who were also fed a high - fat diet, the CD8 + T cells did not produce an inflammatory response, and the mice had near normal blood sugar levels.

They found that the samples from the older normal mice had the most diversity of their gut microbes, including Clostridia and Bacteroides bacteria not seen in the younger mice that were still getting their nutrition entirely from mother's milk.

We have found that expression of C3 in normal mouse eyes leads to pathology similar to AMD in humans, including the creation of anaphylatoxins and the MAC.

Dr. Verdin further found that prolonged intake of a high - fat diet, even in normal mice, can itself reduce the activity of the enzyme produced by SIRT3 — an enzyme his laboratory originally discovered.

We find that delivery of normal factor H reduces pathology in C3 - expressing mice.

They found that the cone function and morphology in mice that had been injected at 14 days were nearly normal, and that the function and morphology of the surviving cones in the mice that had been injected at 90 days had improved — and the number of functioning cones had increased.

They found that the mice developed earlier and more severe disease than mice that had normal Tob1 expression in all cells including CD4 +.

They found that a combination of two compounds - tacrolimus and sirolimus - allowed the cells to survive for up to 28 days in the mice with normal immune systems.

When the researchers induced wounds in these mice, they found that the mice without TSP2 healed significantly better and faster than other mice that had diabetes along with normal levels of TSP2.

Mice exposed to normal TB live for 161 days, while mice infected by bacteria that lack sigF lived for 246 days, according to findings that were reported in Infection and ImmunMice exposed to normal TB live for 161 days, while mice infected by bacteria that lack sigF lived for 246 days, according to findings that were reported in Infection and Immunmice infected by bacteria that lack sigF lived for 246 days, according to findings that were reported in Infection and Immunity.

He studied normal development and tumorigenesis using genetically modified mice and published his findings in very high impact journals.

Researchers comparing normal and obese mice found that obese mice produced more than twice as much of a small microRNA molecule called microRNA - 143 in their liversANCHOR.

Previous studies have shown that aged Polg mutator mice accumulate SNpc mtDNA deletions to a similar extent as that found in the SNpc in both PD patients and aged neurologically normal controls (∼ 50 % of mtDNA molecules harboring deletions)(Bender et al., 2006; Kraytsberg et al., 2006; Perier et al., 2013).

Song and her team found that in mice, the medial septum - to - hippocampus circuit works to keep DG stem cells in this normal, low - activity state.