«We checked a whole rainbow of cells and
found keratinocytes to be the easiest to be reprogrammed,» says Belmonte.
Not exact matches
The new
findings suggest that Neanderthal genetic variants increase the risk of developing sun - triggered skin lesions known as keratoses, which are caused by abnormal
keratinocytes.
Keratinocytes and dermal fibroblasts, which form the connective tissue in skin, responded to increased TWEAK activity by producing a number of chemoattractive and pro-inflammatory factors commonly
found in atopic dermatitis and psoriasis.
The scientists
found that celecoxib directly increased stem cell differentiation into
keratinocytes — skin cells required for wound healing.
In human skin,
keratinocytes, the cells
found in the outer layer of our skin known as the epidermis, soak up our naturally occurring melanosomes.
Gianneschi and his team
found that the synthetic melanin nanoparticles in their experiments were not only absorbed and distributed normally by the
keratinocytes in the epidermis, but they also protected human skin cells from UV radiation damage.
«We plucked a single hair from a co-worker's scalp and cultured the
keratinocytes, which are
found in the outer root sheet area,» recalls Aasen.
These cells are
found between the basal
keratinocytes (this is the major constituent of epidermis.