Not exact matches
Yet a third player in the emerging algae fuel market is Synthetic Genomics, the brainchild
of genomics guru Craig Venter, who beat the U.S. government in sequencing the
human genome and at a
fraction of the cost.
Most
of those studies have focused on the portion
of the
human genome that encodes protein — a
fraction that accounts for just 2 percent
of human DNA overall.
«We were surprised by the results, because we expected a substantial
fraction of the
genome of the red wolf and eastern wolf, maybe 20 % to 30 %, would be derived from a long - distinct species, much as about 1 % to 4 %
of [
human] Eurasian
genomes derive from Neanderthals,» said Wayne.
Faster ways to analyse DNA will speed up the
human genome project, and will be essential if forensics labs are to handle more than a
fraction of the cases that come their way.
The
human genome contains about 3 billion base pairs, but only about 2 percent
of these base pairs represent protein - coding genes, meaning that whole - exome sequencing measures the genetic alterations focused on a small but very important
fraction of the
genome (as opposed to techniques
of whole
genome sequencing, which measures every nucleotide across the entire
genome, regardless
of whether these genes are expressed or silent).
However, approximately 168 Mb remained ambiguous (Table 2) which was more than double the 5.8 %
of the total non-aligning
human genome, the
fraction of known ancestral bases not supported by ancestral elements (Table 1).
Taken together, these studies both highlight a fact that I find myself repeating many times: a significant
fraction of functional variation in the
human genome lies outside the exons
of known protein - coding genes.
We have a variety
of data, both from actual assemblies and simulation studies, which show that about 96 %
of the reference
human genome is addressable using this library and sequencing strategy, including a significant
fraction of the high - copy repeat sequences in the
genome.
It's no secret that while
genome - wide association studies (GWAS) have implicated thousands
of genetic loci in
human phenotypes, the variants uncovered collectively explain only a
fraction of the observed variance between individuals.