Fractional anisotropy refers to how much water molecules move in different directions within the brain's white matter. It helps to show the structural connections between different brain regions.
Full definition
(a) Axial and (b) coronal images show regions of decreased
fractional anisotropy in male patients with mTBI relative to female mTBI patients, involving the uncinate fasiculus (red) bilaterally.
Frey et al (2012) established a novel approach for fiber tracking based on navigated TMS mapping of the primary motor cortex and proposed a new algorithm for determination of an individualized
fractional anisotropy value for reliable and objective fiber tracking.
Comparing MRI brain images of eight Dobermans with CCD to the control group, Ogata found that the CCD group had higher total brain and gray matter volumes, lower gray matter densities in the dorsal anterior cingulate cortex and right anterior insula, and
higher fractional anisotropy in the splenium of the corpus callosum (the degree of which correlated with the severity of the behavioral traits).
Veterans who did not return to work displayed significantly
lower fractional anisotropy (FA) and higher diffusivity in a specific brain region, the left internal capsule.
Effects of signal - to - noise ratio on the accuracy and reproducibility of diffusion tensor imaging -
derived fractional anisotropy, mean diffusivity, and principal eigenvector measurements at 1.5 T.
The scientists found that maternal iron intake correlated inversely
with fractional anisotropy (FA)-- a unit of measurement in DTI that is a useful measurement of tissue organization in the brain — at locations scattered throughout the gray matter of the brain.
• Reduced white matter connectivity (as measured by
reduced fractional anisotropy and increased radial diffusivity) for two discrete clusters on the forceps minor of the corpus callosum; and
The strongest predictions are the frontal pole grey matter volume and the posterior thalamic radiations, both such that greater volume and
greater Fractional Anisotropy (FA) were associated with better scores.
LH GM metrics (i.e., percent spared cortical tissue) and bilateral WM scalars (i.e., fractional anisotropy [FA], mean diffusivity [MD]-RRB- were obtained from cortical and subcortical masks in each ROI.
This imaging technique allows researchers to measure the uniformity of water movement (
called fractional anisotropy, or FA) throughout the brain.
Blue indicates regions of the brain in which
lower fractional anisotropy (a measure of microstructural integrity) correlated with more severe neurobehavioral symptoms.
Just three of these significant differences — radial diffusivity in the right forceps minor, cortical thickness in the left pars opercularis and
fractional anisotropy in the left forceps minor — yielded the best decision tree for distinguishing ASD participants from controls.
In particular, he employs two DTI measures — mean diffusivity and
fractional anisotropy — to evaluate two fundamental elements of cartilage tissue — proteoglycan and collagen.
Fiber tracking was then performed at
a fractional anisotropy value of 75 % and 50 % of the individual FA threshold.
Diffusion Tensor Imaging (DTI) and
fractional anisotropy (FA) have enabled neuroradiologist and neurologists the ability to identify and quantify abnormal patterns within the brain that when paired with a history of trauma, can help to establish the existence of a brain injury.
Whole brain voxel-wise analysis of
fractional anisotropy (FA) was performed by tract - based spatial statistics (TBSS) to localize abnormal white matter regions between groups.
In line with evidence in AB [151] significant differences in
the fractional anisotropy (FA) measures of the uncinate fasciculus have been demonstrated in adolescents with conduct disorder [29,39] as well as in adult psychopathy [144,152].