Sentences with phrase «fragments of rna»

Their work suggests that the process relies on tiny fragments of RNA in sperm that can pass «echoes» of environmental experience down to future generations.

These non-coding fragments of RNA may help to guide the epigenetic machinery to specific locations on DNA.

A number of these trials represent completely novel classes of therapy, such as employing fragments of RNA that interfere with problem genes or developing vaccines meant to quell drug addiction.

«In the early days, these fragments of RNA were generally dismissed as irrelevant since they did not code for proteins.»

The researchers also found differences in microRNA expression in bipolar cells — tiny fragments of RNA that play key roles in the «reading» of genes.

The answer could lie in tiny fragments of RNA that are passed on in sperm cells.

The team's work suggests that the process relies on tiny fragments of RNA in sperm.

Using this technique, the team first identified millions of short fragments of RNA located at the start of genes — at the so - called «5 [prime]» end, where genes are switched on.

Not exact matches

Given the challenges of dealing with freely circulating DNA and RNA fragments, it's no surprise that many scientists are looking for other things to analyze in liquid biopsies.

Dr. Satish Rattan, Professor in the Department of Medicine, Division of Gastroenterology and Hepatology at Jefferson's Sidney Kimmel Medical College, together with Drs. Jagmohan Singh and Ipsita Mohanty, used altered copies of the body's own genetic make - up — small RNA fragments (microRNAs) that regulate the target gene RhoA / ROCK — in order to strengthen or weaken the muscle tone of the sphincter.

When the team used fragments of interfering RNA to sabotage the production of beta - catenin in these stem cells, the blood cells returned to an early leukaemic state.

They found antibodies and viral RNA fragments in three species of bats, including hammer - headed fruit bats.

Replication of viral RNA leads to high amounts of dsRNA which is recognized by the host's RNAi system and chopped up into smaller RNA fragments, called siRNAs (small interfering RNAs).

albopictus mosquitoes that hatched tested positive for Zika RNA (ribonucleic acid), meaning that females collected in the field had encountered Zika and passed fragments of the virus to their offspring.

In a recent test of Asian tiger mosquitoes collected in Brazil, researchers found fragments of Zika virus RNA, raising concerns that it may be carried by species other than Zika's known primary vector, the yellow fever mosquito.

«Telomerase is a unique protein - RNA complex where the protein subunit uses its RNA component as a template to add identical fragments of DNA to the end of chromosomes,» said Emmanuel Skordalakes, Ph.D., associate professor in the Gene Expression and Regulation program of Wistar's NCI - designated Cancer Center.

Pugh added that it was easy to dismiss these fragments because they lacked a feature called polyadenylation — a long string of genetic material, adenosine bases — that protect the RNA from being destroyed.

tRNA fragments — small sections of transfer RNA molecules — have recently been discovered to play active roles in the biology of diverse organisms.

The research team found that this non-coding RNA fragment maintains healthy cells through two mechanisms: Firstly by regulating the levels of DIRAS3, one of its neigboring genes that is involved in cell replication; secondly by suppressing a network of genes that prepare cells to change their shape and prepare for metastasis.

To provide a molecular basis for understanding N - CAM function, the complete amino acid sequences of the three major polypeptides of N - CAM and most of the noncoding sequences of their messenger RNA's were determined from the analysis of complementary DNA clones and were verified by amino acid sequences of selected CNBr fragments and proteolytic fragments.

RT - LAMP relies on primers, DNA fragment sequences, that bind to a target — the RNA of the virus of interest — and then generate a large amount of DNA.

«The method we used involved the sequencing and quantification of RNA molecules in individual cell fragments, something that was never done before,» says Dr. Thijs Ettema, associate professor at the Department of Cell and Molecular Biology, Uppsala University, who led the study.

After the broken fragments were all weeded out, neither jug contained an RNA strand that included sequences that had both a knight in the upper - left corner and a knight in one of the two squares threatened from that position.

It's easier to imagine the spontaneous formation of the nucleotides that make up TNA than those that make up RNA itself, says chemist Leslie Orgel of the Salk Institute for Biological Studies in La Jolla, California, in part because the sugars could be easily assembled by pairing identical two - carbon fragments.

The long and short RNA molecules overlapped with each other, as well, which means that the shorter molecules may be fragments of the longer ones, the researchers report in a paper published online today by Science.

Specifically, the scientists monitored the patient's lung levels of viral RNA fragments known to be associated with Ebola replication, and compared these with viral RNA levels in the patient's blood.

Recent studies revealed that loss of Dicer function to process Alu RNAs to small fragmented RNAs (Alu - siRNAs) underlie the AMD pathology.

New paper available: RNA sequencing of Stentor cell fragments reveals key processes underlying cellular regeneration

mRNA was prepared for sequencing using the TruSeq RNA sample preparation kit (Illumina) with a selected fragment size of 200 — 500 bp.

Low levels of a tiny RNA fragment in cells are associated with metastatic breast cancer in humans and increases the aggressive spread of breast cancer in mice, according to researchers at Whitehead Institute for Biomedical Research.

Biases in coverage distribution, like the GC bias, are problematic, especially in analyses focusing on fragment abundance (e.g., copy number estimation, RNA - seq), but are also of importance for DNA sequencing, where variants in GC - rich and GC - poor regions might be missed due to low coverage.

Unlike typical eukaryotic organisms, Tetrahymena has two nuclei — a micronucleus that contains normal chromosomes and a macronucleus whose chromosomes are fragmented into thousands of small pieces of DNA that all encode the same ribosomal RNA gene.