Sentences with phrase «fragments of proteins from»

Not exact matches

Neurobiologist Ulo Langel of Stockholm University in Sweden, with colleagues at several other labs, solved this problem by pairing PNAs with fragments from two other proteins — transportan or pAntp — that use an unidentified mechanism to slip easily into cells.

To treat humans, researchers must still find a way to deliver the protein fragments past the blood - brain barrier, which prevents circulating proteins from entering the brain, and to the site of the plaques.

The target fragment binds to a gene switch in the DNA, which triggers the production of a colourful substance such as the protein that gives jellyfish a green glow under ultraviolet light, or proteins from bacteria that produce colour changes visible to the naked eye.

Fibrin is an insoluble protein produced by platelets (fragments of white blood cells) from a soluble protein called fibrinogen normally present in blood.

When compared to all collagen sequences in available protein databases as well as sequences Schweitzer obtained in the lab, the T. rex protein fragments most closely resembled those of today's chicken, making the first molecular link and bolstering the idea that contemporary birds descended from dinosaurs.

Asara estimates that collagen protein represented less than one one - hundredth percent of the material he received from Schweitzer, but following a difficult process of extraction and purification, he found six protein fragments, or peptides, that could be sequenced.

Researchers in Cambridge have now shown that this ability depends on a tiny fragment of the animal's haemoglobin the protein that carries oxygen from the lungs to the rest of the body.

Then last year Cappellini and Matthew Collins, a paleoproteomics expert at the University of York in the United Kingdom, and colleagues managed to identify protein fragments from 3.8 - million - year - old ostrich egg shells, a claim that most of their colleagues found convincing.

In the current work, which is reported online this week in the journal PNAS, researchers in the Lindquist lab screened protein fragments from Arabidopsis thaliana, a relative of the mustard plant, and identified 474 that contain prion - like domains.

To confirm that the missing mutations were important for generating an immune response, the researchers cultured a subset of the neoantigen protein fragments containing the tumor mutations with immune cells taken from three patients» blood samples.

The newfound protein might eventually help patients who suffer from the untreatable prion diseases: When the group mixed their artificial protein fragment with a fragment of the PrP protein that usually kills neurons in petri dishes, the mixture killed only half as many cells as the prion fragment alone.

The protein fragment of the vaccine candidate comes from gp120, a protein that covers HIV like a protective envelope.

VIC - 008 is a fusion protein combining an immune - activating protein from the tuberculosis bacteria with a small antibody fragment targeting mesothelin, a protein expressed in several types of tumor — including mesothelioma, pancreatic and ovarian cancer.

In February a group of researchers from Case Western Reserve University reported online in Science that a cancer drug with relatively benign side effects was able to rapidly clear from the brains of mice toxic amyloid - beta protein fragments that accompany Alzheimer's.

(A) Isolated islets from 3 - wk - old, female, Tg - hIAPP mice were cultured in presence of different concentrations of IAPP aggregates prepared in vitro from synthetic IAPP, as well as controls treated with other amyloidogenic proteins, including the Alzheimer's disease — associated protein Tau (the K18 fragment) and the bacterial amyloid Mcc.

But in May, Schweitzer, of North Carolina State University, replicated the results and also announced a bigger find: a collection of even larger protein fragments from an 80 - million - year - old duck - billed dinosaur called Brachylophosaurus canadensis.

The scientists analyzed fragments of collagen — a structural protein found in all animal bones — recovered from 48 fossils of South American ungulate mammals Toxodon platensis and Macrauchenia patachonica.

Our microscopy studies with quantitative co-localization analysis revealed the presence of intraneuronal Aβ in transgenic rats, with an immunological signal that was clearly distinguished from that of the amyloid precursor protein (APP) and its C - terminal fragments (CTFs).

Beta amyloid is a fragment of a protein snipped from another protein called amyloid precursor protein (APP).

The image above shows a digital rendering of the Antennapedia homeodomain protein from the fruit fly (Drosophila melanogaster) bound to a DNA fragment.

The RTS, S vaccine carries a fragment of a protein that sits on the surface of the parasite; the protein is capable of provoking an immune response in humans that is capable of stopping the parasite from maturing and multiplying in the liver.

It comprises a collection of the human proteome represented by 42 000 unique protein fragments from the Human Protein Atlas resource, covering 19 000 protein codingprotein fragments from the Human Protein Atlas resource, covering 19 000 protein codingProtein Atlas resource, covering 19 000 protein codingprotein coding genes.

The approach developed by the MGH team starts with the engineered protein, which in this case fuses an antibody fragment targeting a protein called mesothelin — expressed on the surface of such tumors as mesothelioma, ovarian cancer and pancreatic cancer — to a protein from the tuberculosis bacteria that stimulates the activity of dendritic and other immune cells.

The Meiler laboratory develops technologies to engineer protein, for example through assembly of large protein scaffolds from fragments (Fortenberry, C.; et al.; «Exploring symmetry as an avenue to the computational design of large protein domains»; JACS 2011; 133; 18026 & Eisenbeis, S.; et al.; «Potential of Fragment Recombination for Rational Design of Proteins»; JACS 2012; 134; 4019).

It acts as a caspase inhibitor, which means it could prevent the dangerous huntingtin protein from being broken into small enough fragments to enter the cell's nucleus and mess up the switching on and off of important genes.

The liver makes about 800 to 1500 mg of cholesterol each day, much more that the cholesterol provided in the diet out of fragments from fats, proteins, and carbohydrates.