Sentences with phrase «frameshift allele»
By injecting pairs of TALEN - encoding mRNAs into wild - type embryos, we generated the CCHa2 - RTAL - 34 frameshift allele (Figs 3B and S2B and S2C).
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We imputed these variants into 104,220 individuals down to a minor allele frequency of 0.1 % and found a recessive frameshift mutation in MYL4 that causes early - onset atrial fibrillation, several mutations in ABCB4 that increase risk of liver diseases and an intronic variant in GNAS associating with increased thyroid - stimulating hormone levels when maternally inherited.