These powerful emotions trigger adrenal hormone release — the physiological effects of which include activation of adipocyte lipase (resulting in mobilization of
free fatty acids) and partial inhibition of protein synthesis, i.e., the plasma amino
acids which are normally (readily) utilized by nonmalignant cells for protein synthesis are only partially used resulting in an increase in the
availability of amino
acids to meet tumor cell metabolic needs.
(a) The oxidative catabolism of
free fatty acids and amino
acids (via the Respiratory Chain and Citric
Acid Cycle) might be inhibited in hypoxic cancer cells via the judicious use of agents which inhibit their availability, i.e., partially inhibit hepatic fatty acid synthesis and keep plasma amino acid levels within the normal range, thus decreasing ATP product
Acid Cycle) might be inhibited in hypoxic cancer cells via the judicious use of agents which inhibit their
availability, i.e., partially inhibit hepatic
fatty acid synthesis and keep plasma amino acid levels within the normal range, thus decreasing ATP product
acid synthesis and keep plasma amino
acid levels within the normal range, thus decreasing ATP product
acid levels within the normal range, thus decreasing ATP production;