The increased risk closely correlates with
the frequency of a gene variant previously associated with that adverse reaction, supporting recommendations to screen for that variant in patients from those populations.
Not exact matches
An apparently new
Variant of human serum albumin, albumin Naskapi, has been found in high
frequency in the Naskapi Indians
of Quebec and, in lower
frequency, in other North American Indians.The family and population data
of the albumin are consistent with its inheritance as a simple autosomal trait Controlled by a
gene designated Al Naskapi.
In many cases, the activity
of particular
genes was tied to a single genetic
variant, with strong differences in
frequency between European and African populations.
For instance, when the researchers removed the possible confounding influence
of ApoE4 by looking only at families lacking that ApoE
variant, they found that the
frequency of the mutant A2M
gene in Alzheimer's patients was four times greater than in their siblings who did not have the disease.
Recent studies have found elevated levels
of this protein in post-mortem brain samples
of patients with MS.. In this latest work, investigators compared the
frequencies of «more active» and «less active»
variants of the DNA sequences that control expression
of the galanin
gene between healthy controls and MS patients.
However, when we extracted
gene expression levels from the brain transcriptome data following the methodology in Carneiro et al. [29], we found that levels
of nucleotide diversity and the proportion
of low
frequency variants between lowly (bottom 5 %) and highly (top 5 %) expressed
genes in our dataset (Table S7) were not significantly different in most comparisons (with the exception
of π in O. c. cuniculus) nor did they consistently differ in the expected direction when assuming higher error rates in lowly expressed
genes.
In addition, the data reveal that this was a more genetically diverse population than the central and western European hunter - gatherers living during the same epoch and that they also show pattern
of adaptation to high latitude environments, including high
frequencies of low pigmentation
variants as well as a
gene region associated with physical performance, which shows strong continuity into modern - day northern Europeans.
For each
of the three
genes, one allele (
variant) is found at unusually high
frequency in dogs that have been treated for bloat, and the presence
of any one
of these «risk» alleles triples the chance that the dog will experience bloat at some time in its life.
Doing a genetic test and subsequently eliminating an individual from the breeding population may not be the best strategy, as by targeting a particular allele at one genetic locus for removal from the
gene pool
of a particular breed, breeders may in fact increase allele
frequency of genetic
variants on alternative haplotypes at the same, or a different locus, that are recessively deleterious.
Here, we review recent work that has demonstrated a robust cross-national correlation between the relative
frequency of variants in these
genes and the relative degree
of individualism — collectivism in each population, suggesting that collectivism may have developed and persisted in populations with a high proportion
of putative social sensitivity alleles because it was more compatible with such groups.