Sentences with phrase «frequent mutations»

Prof. Christine Van Broeckhoven (VIB - UAntwerp): «The C9orf72 mutation is the most frequent mutation in FTD and ALS.

It is mutated in 80 to 95 percent of pancreatic ductal adenocarcinomas (PDAC), the most frequent mutation in this cancer.

(The K - Ras gene is mutated in 20 percent of lung cancer cases, and G12C is the most frequent mutation of K - Ras.)

In this study, investigators showed that approximately 25 percent of tumors that pathologists classified as high - grade endometrioid showed frequent mutations in TP53, a tumor suppressor gene, as well as extensive copy number alterations, a term for when a cell has too many or too few copies of a genomic segment.

So far, the procedures for the identification of the most frequent mutations affecting BRCA1 and BRCA 2 have been extremely time - consuming and costly.

Interestingly, two studies of melanoma cell lines revealed frequent mutations in mitogen activated protein (MAP) kinase kinase [kinase] genes MAP2K1, MAP2K2, MAP3K5, and MAP3K9.

But the protein is genetically diverse across different strains of malaria — probably from frequent mutations to avoid immune detection — and RTS, S includes just one form, or allele.

Frequent mutation of histone - modifying genes in non-Hodgkin lymphoma.

The research shows that most frequent mutations are the ones which give rise to truncated proteins, shorter and non-functional.

Most endometrioid tumors, by contrast, have few copy number alterations or mutations in TP53, though there are frequent mutations in other well known cancer - associated genes, including PTEN, another tumor suppressor gene, and KRAS, a gene involved in regulating cell division.

The most frequent mutation the researchers found in influenza in pregnant mice was a variant that further dampens the innate immune response, giving the virus an even better chance to survive and thrive.

Although a great diversity of viral strains develop in patients due to frequent mutations, not all of these strains are transmitted.

We have developed a modified version of the ice - COLD - PCR assay called Enhanced - ice - COLD - PCR for KRAS, BRAF and NRAS mutation detection and identification, which allows the enrichment of the most frequent mutations and requires only a small amount of starting material (frozen, FFPE or plasma) permitting the sensitive detection and multiplexed sequence identification of mutations within three hours.

In addition, TCGA identified a multitude of less - frequent mutations in other genes.