Sentences with phrase «frequently altered gene»

The researchers further found that miR - 486 is itself regulated by the tumor - suppressor gene p53, the most frequently altered gene in human cancers, and that activity of miR - 486 is partially dependent upon functional p53.

These tumor suppressor genes are two of the most frequently altered genes in human cancer, and understanding how they function at the molecular level will both refine our fundamental understanding of this disease and suggest novel therapeutic approaches to treat it.

The most frequently altered genes in SCC were TP53 (20/25 cases, 80 %), PIK3CA (13/25 cases, 52 %) and CDKN2A (11/25 cases, 44 %).

Intriguingly, one of the most frequently altered genes, mutated exclusively by inactivating mutation, was LYST (10 %), which may represent a novel cancer gene in chordoma.Chordoma is a rare often incurable malignant bone tumour.

Not exact matches

New research has found that the pharmaceuticals, which are frequently showing up in U.S. streams, can alter genes responsible for building fish brains and controlling their behavior

Beyond identifying the Sestrin1 gene as frequently altered in FL patients, the scientists demonstrated that Sestrin1 is able to suppress tumors in vivo.

In addition, they also found that several important histone regulator genes such as MLL2, ASH1L, MLL3, SETD1B and CREBBP / EP300 are frequently altered in ESCC.

Frequently insertions / deletions alter the open reading frame (ORF) of the target gene, disrupting the gene function downstream of the DSB.

Miller said that the viral receptor gene, HYAL2, was located on a region of human chromosome 3 that is frequently altered in lung cancers.

Rather than modify protein structure and function, these noncoding variants frequently impact regulatory elements and thereby alter the quantitative and spatiotemporal regulation of gene expression.