Donated
fresh oocytes traditionally have been used immediately, creating embryos for transfer into the uterus, with extra embryos being cryopreserved for later use.
Compared to using
fresh oocytes (eggs) for in vitro fertilization, use of cryopreserved (frozen) donor oocytes in 2013 was associated with lower live birth rates, according to a study in the August 11 issue of JAMA.
Initiated cycles were canceled in 12 percent of
fresh oocyte cycles vs 8.5 percent of cryopreserved oocyte cycles.
Not exact matches
With advances in
oocyte cryopreservation technology, fertility rates using frozen eggs are comparable to rates with
fresh eggs.
Study leader Andrew French says the key to the team's success was utilizing
fresh, mature
oocytes from females of proven fertility.
Per embryo transfer, the live birth rates were 56 percent with
fresh vs 47 percent with cryopreserved
oocytes.
Per started recipient cycle, the live birth rates were 50 percent with
fresh vs 43 percent with cryopreserved
oocytes.
«Thus, having fewer mature
oocytes can mean fewer embryos to choose from for
fresh transfer or future transfer following cryopreservation, particularly among women who respond poorly to ovarian stimulation.»