Not exact matches
It offers cardio protection, it helps lower bad cholesterol, it may help prevent the progression of multiple sclerosis, it has the ability to regenerate
brain cells after a stroke, it has the ability to cross the blood -
brain barrier to potentially ward off Alzheimer's disease, apparently it's good at wiping amyloid plaque
from the
brain (which studies haves linked to Alzheimer's), it may help to prevent certain types of cancer, and studies have shown that it inhibits cancer cell growth and
metastases (meaning it keeps cancer
from spreading).
Before this study was carried out, the extent to which the genetic profiles of
brain metastases differ
from that of the primary was unknown.
Research
from McMaster University has identified new regulators of
brain metastases in patients with lung cancer.
«
Brain metastases are a secondary brain tumour, which means they are caused by cancer cells that escape from primary tumours like lung, breast or melanoma, and travel to the brain,» said Mohini Singh, the study's primary author and a PhD candidate in biochemistry at the Michael G. DeGroote School of Medicine at McMa
Brain metastases are a secondary
brain tumour, which means they are caused by cancer cells that escape from primary tumours like lung, breast or melanoma, and travel to the brain,» said Mohini Singh, the study's primary author and a PhD candidate in biochemistry at the Michael G. DeGroote School of Medicine at McMa
brain tumour, which means they are caused by cancer cells that escape
from primary tumours like lung, breast or melanoma, and travel to the
brain,» said Mohini Singh, the study's primary author and a PhD candidate in biochemistry at the Michael G. DeGroote School of Medicine at McMa
brain,» said Mohini Singh, the study's primary author and a PhD candidate in biochemistry at the Michael G. DeGroote School of Medicine at McMaster.
The study used samples
from lung cancer patients with
brain metastases.
Since whole -
brain radiation is associated with significant cognitive effects and the use of additional radiation therapy for progression is common in this population, the Yale researchers suspect that patients with the ALK mutation would benefit
from radiation focused on individual
metastases.
Thus, based on the robust findings
from the current study and until proven otherwise, WBRT may still have an important role for treatment of patients who are not in this specific disease category (i.e., 1 - 3
brain metastases).
The Nakano lab is also working on
brain metastases, tumors that spread into the
brain from other parts of the body.
«In cancer, it's usually the
metastases to the lung, liver or
brain that kill the patient, but it's hard to get tissue safely
from these areas,» said Rick Lanman, MD, Guardant Health's chief medical officer.
After confirming in mouse models that cells
from HER2 - positive breast cancers became resistant to anti-HER2 treatment when implanted into the
brain but not into other tissues, the investigators found that HER3 is overexpressed in
brain metastases of HER2 - positive breast cancers
from both mice and human patients.
«Metastatic
brain tumors — often
from lung, breast or skin cancers — are the most commonly observed tumors within the
brain and account for about 40 percent of advanced melanoma
metastases.
«Metastatic
brain tumors — often
from lung, breast or skin cancers — are the most commonly observed tumors within the
brain and account for about 30 percent of advanced breast cancer
metastases,» says Khalid Shah, MS, PhD, director of the Molecular Neurotherapy and Imaging Laboratory in the MGH Departments of Radiology and Neurology, who led the study.
Current treatments for both primary
brain tumors and
brain metastases (cancer that has spread to the
brain from another place in the body) are low in number and short on effectiveness.
Safety and clinical activity of ipilimumab in melanoma patients with
brain metastases: retrospective analysis of data
from a phase 2 trial.
The study conducted at SciLifeLab shows that temozolomide itself not only is cytotoxically active against glioblastoma tumors but also against other types of
brain tumors, such as medulloblastoma and
metastases from other primary tumors.
Early results
from an ongoing trial suggest that pembrolizumab has promising activity in untreated melanoma patients with
brain metastases.
A phase III study of TTFields following Stereotactic Radiosurgery for 1 - 10
Brain Metastases from Non-Small-Cell Lung Cancer more...
Central nervous system (CNS) tumors pose a particular challenge for antibody therapeutics, because the blood -
brain barrier (BBB) prevents intravenously - injected antibodies
from reaching CNS
metastases.