Sentences with phrase «from plasma cells»

A Neutralizing Antibody Selected from Plasma Cells That Binds to Group 1 and Group 2 Influenza A Hemagglutinins

Not exact matches

During pregnancy, many women suffering from HELLP syndrome require a transfusion of some form of blood product (red cells, platelets, plasma).

Vortex's system uses a microfluidic chip to generate tiny vortices that trap larger, more deformable cancer cells from a blood plasma sample.

«The problem with plasma cell - free liquid biopsy in particular is that the amount of wild - type [DNA] can be very, very high, and so keeping that really rare signal from being swamped out by the wild - type... is key,» says Dawne Shelton, R&D manager for in vitro diagnostic products at Bio-Rad in Hercules, California.

The viral plasma membrane is mostly co-opted from that of the host cell as newly formed viruses bud from infected cells.

Thus, transport of peptide — MHC II complexes by DCs not only accomplishes transfer from late endocytic compartments to the plasma membrane, but does so in a manner that selectively concentrates TCR ligands and costimulatory molecules for T cell contact.

The new findings build on prior research from the Dhodapkar lab demonstrating that patients with Gaucher disease, an inherited lipid storage disorder, have a significant increased risk for developing myeloma; and the discovery of a subset of lipid - reactive immune cells, called type II NKT - TFH, that promote the development of plasma cells.

They received either a saline placebo or plasma — blood from which the red cells have been removed — from blood donors aged 18 — 30.

The method relies on a special dye that shows up brown when mixed with whole blood, but turns teal when mixed with plasma that has been separated from red blood cells.

Then there's the West Palm Beach symposium, held to recruit participants for a study testing what happens when aging people get infusions of plasma (the fluid part of blood packed with signaling proteins and other molecules but no red or white cells) from young people who've taken a drug meant to activate their immune system.

To simulate the results from a hypervelocity impact plasma, researchers used a method called particle - in - cell simulation that allows them to model the plasma and the electromagnetic fields simultaneously.

In a new paper, he and colleagues reveal that host cells sequester viral proteins away from the plasma membrane within the cell, thus preventing viruses from spreading.

Epidermal growth factor receptor (EGFR) mutations found in the circulating free tumor DNA (ctDNA) from the plasma of advanced non-small cell lung cancer (NSCLC) patients correlates well with the EGFR mutations from patient - matched tumor tissue DNA.

In vitro experiments and high - throughput RNA sequencing revealed that CTCF deletion profoundly altered the B lymphocyte transcriptional program, shifting cells from a gene expression profile typical of the germinal center to one more similar to that seen in plasma cells.

Research suggests that very scarce chemical cues can trigger physical changes in the cell, including remodeling the plasma membrane and recruiting cytoskeletal machinery, to transform the dichty from a fat, happy cell to an elongated cell with a distinct front and rear end, ready to migrate.

Gαs went from lipid rafts to nonraft regions of the plasma membrane in the glioma cells, which enhanced its signaling ability.

Plasma from old mice didn't have a strong effect when injected into young mice genetically engineered to lack VCAM1 in certain blood - brain barrier cells.

Although myeloma is, like leukemias and lymphomas, a cancer involving white blood cells known as lymphocytes, myeloma cells don't traditionally express CD19 on their surface because they arise from the most mature type of lymphocytes — plasma cells.

In each blood sample, the researchers separated the plasma, the liquid part of the blood, from the blood cells.

The cell - free DNA extracted from the plasma and, separately, the genome of white blood cells were then sequenced using the high - intensity, 508 - gene sequencing assay.

Or they can treat patients with plasma exchange, in which the body's red blood cells are separated from the plasma (which carries the antibodies and other immune cells) and then returned without the plasma.

It turns out that all pregnant women carry some fetal cells and DNA, with up to 6 percent of the free - floating DNA in the mother's blood plasma coming from the fetus.

In the new study, he and his team sequenced DNA from the plasma — blood minus the cells — of a woman who was 18.5 weeks pregnant.

Target detectability data from 858 samples from 11 independent customer sites, utilizing five unique sample types: serum, plasma, cell culture supernatant, lysates, and bronchoalveolar lavage.

The cells were mixed with platelet - dense plasma isolated from the patients» blood and injected into their eyes.

Circulating cell - free DNA (cfDNA) isolated from plasma or serum by noninvasive procedures can serve as a «liquid biopsy» and has potential as a biomarker for the tumor burden and survival prediction of breast cancer (BC).

Nef exosomes isolated from the plasma of individuals with HIV - associated dementia (HAD) can induce Aβ1 - 42 secretion in SH - SY5Y neural cells.

Tissues being sampled include biopsy material from target organs, peripheral blood cells and serum / plasma, germline DNA, and stool for microbiota analysis.

Plasma from stored packed red blood cells and MHC class I antibodies causes acute lung injury in a 2 - event in vivo rat model.

GigaGen captured millions - diverse DNA libraries from B cell and plasma cell repertoires from human donors and used these libraries to manufacture recombinant IgG proteins.

«Their shock would resolve, their bleeding would resolve a lot quicker than just using plasma and red cells that we had shipped from home.»

Rotavirus NSP4: Cell type - dependent transport kinetics to the exofacial plasma membrane and release from intact infected cells.

CD20 is a B - lymphocyte surface molecule that is widely expressed during B - cell ontogeny, from early pre-B-cell developmental stages until final differentiation into plasma cells.

For more information from the National Cancer Institute about multiple myeloma and other plasma cell neoplasms, see the following:

Plasma cells develop from B lymphocytes (B cells), a type of white blood cell that is made in the bone marrow.

Our group has 3 major goals: Develop novel therapeutic approaches based on centrosomal clustering To further develop our first prototype inhibitors of centrosomal clustering preclinically and to establish a robust and specific high throughput small molecule screen Discover key events in myeloma pathogenesis To investigate the pivotal transition from the pre-malignant, asymptomatic to malignant, symptomatic stages of plasma cell dyscrasias in order to understand the pathophysiology and thereby identify novel targets Translate small molecule therapeutics from bench to clinical trials To evaluate novel agents in the preclinical setting and to initiate early phase clinical trials in hematologic malignancies with focus on multiple myeloma

«A whole generation of cancer investigators, including me, has been taught that PTEN performs its crucial role at the plasma membrane, which is what separates the inside of cells from the outside environment» Trotman explains.

Western blot analysis of antibody specificity has been done using a routine sample setup composed of IgG / HSA - depleted human plasma and protein lysates from a limited number of human tissues and cell lines.

The Clinical Core of the Cleveland Alcohol Center can provide CAC investigators to access to de-identified biological samples (tissue biopsy, plasma / serum, urine, DNA and peripheral blood mononuclear cells (PBMCs) from patients with different stages of alcoholic liver disease, as well as healthy control subjects.

We furthermore proved that the GM - CSF / Lyn / Stat3 pathway that contributes to growth of leukemic cells could be profoundly affected, by using a new plasma membrane disrupting agent, which rapidly delocalized CD45 away from lipid rafts.

In Stiff Person Syndrome, which is a rare autoimmune disease in the central nervous system with autoantibodies targeting glutamic acid decarboxylase (GAD65), the humoral autoimmune response was shown to consist of a Rituximab - sensitive part rapidly cleared after treatment, and a Rituximab - resistant part from long - lived and persistent plasma cells acting as a reservoir for secretion of autoantibodies.

Endosomes are the main organelles for sorting material that has been taken up from the exterior of the cell by the plasma membrane (endocytosis).

Modality of access under this proposal: Users can provide human or animal serum, plasma or tissue samples, or cell pellets or supernatants from cell models.

Injections of Growth Factors, when used for many other types of medical treatments, are made from a patient's own blood and blood cells and is called PRP (Platelet Rich Plasma) or PDGF (Platelet Derived Growth Factors) Therapy.

TruePrimeTM Necrotic cell - free / exosomal DNA amplification kit For the amplification of genomic DNA starting from cell - free DNA obtained from plasma, serum, urine or any other bodily...

The TruePrime ™ Necrotic cell - free / exosomal DNA amplification kit uses a novel multiple displacement amplification method based on the combination of the recently discovered DNA primase TthPrimPol, and the highly processive and high - fidelity Phi29 DNA polymerase, to amplify genomic DNA starting from cell - free DNA * obtained from plasma, serum, urine or any other bodily fluid.

On arrival, the samples were centrifuged (1200 × g, 15 min, room temperature) to separate plasma from buffy coat and red blood cells, and the samples were frozen in liquid nitrogen until they were analyzed.

Elevated plasma concentrations of soluble forms of endothelial adhesion molecules, released from shedding or proteolytic cleavage from the endothelial cell surface, are considered useful indicators of endothelial dysfunction and activation (20, 25).

As blood flows throughout the body, a thin, yellow fluid called plasma leaks out from blood vessels and mixes with interstitial fluid and water to surround the cells in different tissues.

Platelet - rich plasma is obtained via a process called centrifugation that removes red and white blood cells from a blood sample while leaving behind a high concentration of platelets in the plasma.