Sentences with phrase «from animal experiments»

Look at specific human break through from animal experiments, do these justify experiments now?

Insofar as we can generalize from these animal experiments to humans, they provide a potential rationale for using low - protein diets to treat cancer patients, and raise the important clinical question of how to best maintain proper detoxification in these patients.

The guidelines have been developed by the NC3Rs to improve standards of reporting and ensure that the data from animal experiments can be fully evaluated and utilised.

«It is indeed a remarkable finding that is consistent what with what one would have expected from prior findings from animal experiments,» said lead author Jie Li, a Brown postdoctoral fellow.

Yet much of the evidence cited by smart drug enthusiasts comes from animal experiments which can, by virtue of their design, test only a drug's effect on learning, not recall.

Based on the amounts being found in people and what is known about the metabolism of bisphenol A from animal experiments, it also appears that human exposures are above the current U.S. safety limit, according to the assessment.

Not exact matches

He has achieved fame by experiments in which, after removing the amygdalae from the brains of cats, he observed that the cats veered «helplessly from one inappropriate affect to another, boredom where there should be fear... sexual arousal where there was nothing that would stimulate an intact animal.»

Then in 1961 Stanley Jacob, a University of Oregon Health Sciences Center surgeon looking for a way to supercool animal organs for transplant experiments, learned of DMSO from Robert Herschler, a chemist employed by the Crown Zellerbach paper company.

This printed eyelash scarf (currently on sale for $ 29.50) from J. Crew Factory is available in several bold prints; the sweet hyacinth (shown) is a fun option is you want to experiment with animal prints.

Much of what we know about how animals change appearance during domestication comes from a famous experiment in Siberia in the 1950s.

Insights from experiments on animals are often difficult to apply to humans, Hartung, of Johns Hopkins University, said in a news briefing February 12.

Among other things, the law requires facilities to win approval for animal experiments from the Committee for the Purpose of Control and Supervision of Experiments experiments from the Committee for the Purpose of Control and Supervision of Experiments Experiments on Animals.

In another animal microbiome experiment, Jeffrey Gordon, a biologist at Washington University in St. Louis, took a suite of microbes from the guts of both obese and lean mice and transplanted them into the guts of microbe - free mice.

And instead of surmising the animals» thinking from field observations or working with a single trained subject, she conducted repeatable laboratory experiments, carefully designed to rule out alternative interpretations, with multiple birds whose history was uncorrupted by previous work.

One of the earliest compelling studies to suggest a relationship between diabetes and air pollution was an animal experiment published in 2009 in Circulation from researchers at Ohio State University and other institutions.

They are part of a long - running biological experiment to repeat domestication by turning a wild canid — from the family of animals including wolves, foxes, jackals and dogs — into a fox version of a domestic dog (SN: 5/13/17, p. 29).

In a final experiment, the group gave the animals a compound that prevented LPA from binding to its receptor on mouse brain cells, right before they were injected with hydrocephalus - inducing LPA.

But it wasn't clear from mouse experiments if the SCN was responsible for this resistance to strong temperature changes in living animals.

Nevertheless, there remain many gaps in scientists» understanding of the effects of blasts on the human brain; most new knowledge has come from experiments with animals.

Complex phenomena — which we have so far only been able to study in live animals - can now be investigated in simple laboratory experiments using cultivated cells,» says postdoc Hans Christian Cederberg Helms from the Department of Pharmacy.

Collins said that because Hydra is such a simple animal and because it is able to regenerate after complete dissociation into individual cells, it offers researchers the opportunity to use similar techniques as the ones employed in their experiments to examine how an organism develops from an unstructured group of cells into a complex body plan.

The evidence that oxygen radicals were beneficial came from experiments in which researchers gave animals an antioxidant called N - acetyl cysteine.

Experiments demonstrated that, even after being stored at 40ºC for 6 months, their rabies vaccine protected animals from viral infection.

She needed a farm to host an audacious experiment dreamed up by geneticist Dmitry Belyaev: to create a domestic animal as docile as a dog from aggressive, wily silver foxes.

Using clinical, genetic, and gene expression data as filters to distinguish genes whose copy number alteration causes cancer from those for whom copy number changes are incidental, the team whittled down their list from 14,000 to a more manageable number, each of which they systematically tested using genetic experiments in animals.

The case is in keeping with the recent European trend of increasingly stringent regulations for animal research; most notably, a September 2007 petition in the European Parliament to end all nonhuman primate experiments gained support from more than half of its members.

In experiments with mice, the researchers calculated a seventyfold drop in the amount of Sema3D secreted from mouse pancreatic cancer cells in animals that lacked annexin A2.

This perfectly preserved frondlet from the Ediacaran period 565 million years ago was an early experiment in animal life that never evolved into another stage.

The loss was bad for the vaccine: In a series of experiments Hensley and his colleagues showed antibodies from humans and ferrets (a good animal model for influenza A studies) that had been exposed to the egg - grown vaccine did not effectively kill the circulating sugar - adorned viruses.

The results indicate that the highest number of new hippocampal neurons was observed in rats that ran long distances and that also had a genetic predisposition to benefit from aerobic exercise: Compared to sedentary animals, HRT rats that ran voluntarily on a running wheel had 2 - 3 times more new hippocampal neurons at the end of the experiment.

In order to identify and avoid possible risks that could arise from vaccination against AIDS, it is essential to carefully plan and execute animal experiments in pre-clinical studies.

«A drug produced from scratch needs to be proven both safe and effective before the FDA will permit its use, and that is a painstaking and expensive process requiring extensive animal experiments,» Hanauske - Abel says.

For the animal experiments, Savio Woo of the Center for Gene Therapy at Baylor College of Medicine in Houston and his colleagues first isolated liver cells from transgenic mice that produce the human protein a1 - antitrypsin in their livers, from where it is secreted into the blood.

In experiments on monkeys, they combined an antibody to OX40 with the drug rapamycin, which slows production of IL - 2, and saw «total control» of GVHD: Five of five animals had no signs of the disease 100 days after a graft from a highly mismatched donor.

A cheap and simple test that identifies skin irritants in cosmetics and drugs could save thousands of animals from a life of suffering in laboratory experiments.

As we learn in Escape from the Planet of the Apes (1971), the third installment of the series, Dr. Zira vivisected and experimented on human captives, who in the movie year of 3955 are considered animals and thus expendable in the pursuit of scientific knowledge.

Findings may be having a profound impact on everything from animal behavior experiments to human clinical trials

What is emerging from this work is a fascinating possible scenario for the humble beginnings of the mighty animal kingdom: A few thousand spore cells in the ocean, poised to scatter like dandelion seeds, may have decided to stick together and continue their experiment in group living for a little while longer.

Accepting space and time as forms of animal sense perception (that is, as biological), rather than as external physical objects, offers a new way of understanding everything from the microworld (for instance, the reason for strange results in the two - slit experiment) to the forces, constants, and laws that shape the universe.

The drones the duo have been experimenting with can hear the bats from around 20 metres away, so they aren't thought to pose any danger to the animals.

Experiments performed by coauthor Mireia Uribe - Herranz, PhD, a research associate in Facciabene's lab, demonstrate that when ACT was performed on genetically identical animals obtained from different vendors (Jackson Laboratory or Harlan Laboratories), which carry different microbiota, impact of the therapy was not identical.

Recommendations aimed at reducing the incidence of cancers associated with nutrition are based on limited but suggestive evidence from epidemiological studies and animal experiments

In experiments in animals, researchers from the University of Michigan Medical School showed that adding rapamycin to an immunotherapy approach strengthened the immune response against brain tumor cells.

«We had some indication that rapamycin would enhance the cytotoxic T cell effect, from previous experiments in both animals and humans showing that the drug produced modest effects by itself,» says Maria Castro, Ph.D., senior author of the new paper.

In experiments in mice, the researchers found that the activity of Sst interneurons changes when the animal goes from not moving its whiskers (in a resting state) to moving them (in an active state), a process known as whisking.

In an experiment aimed to uncover how concepts are represented in the brain, 29 participants, ages 18 - 28, first viewed several novel cartoon animals as examples from two different concept categories whose members were related to families called Romeo or Juliet.

A second experiment showed that the drugs - plus - DNA therapy reduced bacterial growth from a secondary infection, and in one of seven animals, it gave «complete protection» to the lungs against reinfection.

«What's particularly noteworthy about this work is we were able to present an integrative link from genetics, cell - and animal - based experiments, all the way up to clinical outcomes in large human population,» Liu said.

The immunological benefits from the wild mice's gut bacteria may, in part, explain a persistent problem in disease research: Why disease experiments in lab mice, such as vaccine studies, turn out very differently in humans or other animals.

In the experiments with F66 transgenic mice, a consistent finding was that muscle weights were higher in animals of the same genotype if they arose from crosses in which the mother had fewer functional Mstn alleles (Table 1).