Sentences with phrase «from animal models»

Once we have all the data from those animal models and from our observational study we can proceed.

The first genetic clues for slowing aging emerged from animal models in which the effect of individual genes on average life spans could be tested.

Much of our knowledge about the importance of the microbiome comes from animal models, but we do know a few things about its importance in humans.

And of course we need to determine to what extent we can extend these principles from animal models to humans.

«Some of these effects are really hard to predict from animal models because the situations that lead to them are idiosyncratic,» says Linda Griffith, the School of Engineering Professor of Teaching Innovation, a professor of biological engineering and mechanical engineering, and one of the senior authors of the study.

Although caution is warranted in extrapolating findings from animal models to humans, these findings have implications for individualized approaches to treating autism.

«We know from animal models that there are critical periods during early development when cells are rapidly dividing and forming the circuitry through which cells will communicate with each other to form various tissues of the body,» said Retha Newbold, a reproductive biologist at the National Institute of Environmental Health Sciences in North Carolina.

However, in several neurodegenerative diseases, evidence from animal models suggests the unfolded protein response stays too active for too long.

«We will follow up using more human islets and trying to understand how many of these functions translate from animal models to humans,» says Bonner - Weir, who notes that human islets are far more diverse than those in lab animals.

Mechanisms Underlying Weight Loss with Bariatric Surgery: Lessons from Animal Models ENDO Session No credit available Randy J. Seeley, PhD Hear how animal models are shedding light on how bariatric surgery affect weight loss as well as many other metabolic outcomes.

«The biggest challenge for neuroscientists is translating research from animal models to humans and the translation fails most often because the experiments don't look alike,» says Martinez - Trujillo, who also holds Western's Provincial Endowed Academic Chair in Autism.

Further, results from animal models argue that Candida colonization delays healing of inflammatory lesions and that inflammation promotes colonization.

«Some of these effects are really hard to predict from animal models because the situations that lead to them are idiosyncratic.

Although most of these biosubstances have been identified in mother's milk in quantities that exceed maternal serum levels, their exact role in human newborns is uncertain; most current information is from animal models whose development may significantly differ.

Hackett said, «Studies of human immunology are usually not the first choice for research in basic immunology, but it is very important now to understand how humans differ from animal models.»

They found that their observations from animal models held true in that the average length of all the DNA pieces present in the blood from melanoma patients was 20 - 50 base pairs shorter compared to the DNA pieces in blood from healthy volunteers.

Our results show a dynamic configuration of threat responses that include the PAG and are akin to what might be predicted from animal models of defensive avoidance (6, 7) and fear (10).

Assistant Professor Arindam Basu from NTU's School of Electrical and Electronic Engineering said the research team have tested the chip on data recorded from animal models, which showed that it could decode the brain's signal to the hand and fingers with 95 per cent accuracy.

«Now we can actually test humans and animal models within exactly the same environment and very similar settings, which allows for generalization from animal models into humans and makes the research findings translational,» says Martinez - Trujillo.

Additional protocols are currently under development to measure SMN protein in other tissues and biofluids, as well as in various tissues from animal models.

They used sophisticated molecular biology approaches, together with experiments that deleted specific genes from the animal models, to fill in the steps that led from Vegf signaling to Dll4 activation.

Conventional wisdom is scared of those oils because they contain two lipid compounds called cafestol (great name for a coffee shop) and kahweol, high doses of which elevate cholesterol and suppress LDL clearance from animal models.

We know from animal models that if we start an intermittent fasting diet at what would be the equivalent of middle age in people, we can delay the onset of Alzheimer's and Parkinson's.

Emerging evidence from animal models and clinical trials suggest keto may be therapeutically used in many other neurological disorders, including head ache, neurodegenerative diseases, sleep disorders, bipolar disorder, autism and brain cancer.

Lessons from animal models.

But the invasive nature of the treatment, and the notorious difficulty in translating neuropsychiatric research from animal models to humans, could complicate its path to the clinic.

The journal provides cutting - edge research including results from animal models that are likely to apply to patients, studies in human tissue that provide new information about therapies or disease, and innovative reports of drug discovery and development.

Genetics is also important for understanding how research scales up — or fails to — and translates from animal models to humans and among different human populations, says Henry Bryant, a research fellow at Lilly Research Laboratories in Indianapolis.

Prosecuting would be a «difficult and unworkable task, as little or no evidence is available regarding [the substances»] pharmacological activities in vivo in humans and expert witnesses may be reluctant to extrapolate data from animal models, in silico or in vitro studies,» lecturer in criminal law Amber Marks told the committee.

This corresponds to findings from animal models: A lot of micro-RNA 155 is associated with reduced fat burning.

«It's going to be driven by the data that we obtain» from animal models.

«We know from animal models,» says Mark Mattson at the National Institute on Aging, «that if we start an intermittent fasting diet at what would be the equivalent of middle age in people, we can delay the onset of Alzheimer's and Parkinson's.»

On the basis of these consistent and robust data from animal models, a recent report in European dieters found a significant association between the timing of lunch and weight - loss effectiveness, with earlier lunch times linked to greater success (45).

Although no studies have yet examined whether maternal relationship quality during pregnancy is linked to the risk of infectious disease in the offspring, there is growing evidence from animal models that a link exists between prenatal maternal stress and a wide range of adverse health outcomes in the offspring, including immune dysfunction and infectious diseases [14,15].