Again, using mouse models of glioblastoma — this time created
from brain tumor cells that were resistant to the herpes virus — the therapy led to increased animal survival.
Not exact matches
So far, researchers with the Allen Institute for
Brain Science in Seattle have described the intricate shapes and electrical properties of about 100 nerve cells, or neurons, taken from the brains of 36 patients as they underwent surgery for conditions such as brain tumors or epil
Brain Science in Seattle have described the intricate shapes and electrical properties of about 100 nerve
cells, or neurons, taken
from the
brains of 36 patients as they underwent surgery for conditions such as
brain tumors or epil
brain tumors or epilepsy.
HBI member V. Wee Yong, PhD and research associate Susobhan Sarkar, PhD, and their team including researchers
from the Department of Clinical Neurosciences and the university's Southern Alberta Cancer Research Institute, looked at human
brain tumor samples and discovered that specialized immune
cells in
brain tumor patients are compromised.
To seed in the
brain, a cancer
cell must dislodge
from its
tumor of origin, enter the bloodstream, and cross densely packed blood vessels called the blood -
brain barrier.
Engineered human immune
cells can vanquish a deadly pediatric
brain tumor in a mouse model, a study
from the Stanford University School of Medicine has demonstrated.
They observed that the
tumor cells that spread to the
brain were able to utilize an extracellular molecule, which shields them
from their hostile surroundings.
If we can boost the immune system and allow microglia to do their job and control
brain tumor stem
cells, it would be like removing the seed
from the soil — stopping the
tumor growth before it starts to get out of control.»
ICELL8 can isolate up to 1,800 single
cells, ranging
from 5 μm — 100 μm in size on a single chip, including
cells from solid
tumors,
brain cells, pulmonary airway
cells, and multiple
cell lines.
Now he and his team are putting
cells from human
brain tumors into the organoids, which have reached the level of development and complexity of a 20 - week - old human fetus's, to see whether they reprise what happens in patients.
The most common primary, malignant
brain tumors in adults, called glioma, are formed
from cells in the
brain that are not nerve
cells.
Because the stem
cells generate the
brain cancer
cells, killing off the stem
cells might prevent
tumors from recurring.
«We showed that the presence of the maternal gut microbiota during late pregnancy blocked the passage of labeled antibodies
from the circulation into the
brain parenchyma of the growing fetus,» says first author Dr. Viorica Braniste at the Department of Microbiology,
Tumor and
Cell Biology at Karolinska Institutet.
In a new study, Yale Cancer Center researchers identified a novel genetic defect that prevents
brain tumor cells from repairing damaged DNA.
The team's experiments in
cell cultures, conducted with funding
from an American
Brain Tumor Association Discovery Grant, showed that coibamide A cuts off the cancer
cells» ability to communicate with blood vessels and other
cells, eventually starving the
cell and triggering its death.
In experiments in animals, researchers
from the University of Michigan Medical School showed that adding rapamycin to an immunotherapy approach strengthened the immune response against
brain tumor cells.
«They can cross different fiber tracts in the
brain to reach
tumor cells that have migrated away
from the main
tumor mass.
Researchers demonstrated that the drugs pemetrexed and gemcitabine killed
cells from mouse and human
brain tumors, called group 3 medulloblastoma, growing in the laboratory.
«Inhibition of the EZH2 pathway slows growth of
tumors in mouse
brain derived
from glioma stem
cells from the enhancing margin of human
tumors.
Past clinical trials of stem
cell therapies for chronic stroke patients used
cells derived
from tumors in humans and
brain tissue
from fetal pigs.
CSCs were prepared
from 231BrM and CN34BrM
cells that were infected with lentivirus carrying with or without miR -7-2, and they were transplanted into nude mice through intracardiac injection followed by monitoring metastatic
tumor growth in the
brain.
The safe use of a stem -
cell - based therapy against
brain metastasis would require preventing the engineered
cells from persisting within the
brain, where they could affect normal tissue and possibly give rise to new
tumors.
Investigators
from Brigham and Women's Hospital (BWH) and the Harvard Stem
Cell Institute have a potential solution for how to kill
tumor cells that have metastasized to the
brain.
Working with Seattle, Washington — area neurosurgeons, the Allen Institute acquired healthy
cells from the cortex — the outermost layer of the
brain that coordinates perception, memory, thoughts, and consciousness —
from patients undergoing surgery for epilepsy or
brain tumors.
In this report, we indeed showed that CSCs isolated
from both 231BoM and 231BrM have strong
tumor - initiating abilities; however, they preferentially metastasize to bone and
brain, respectively, despite the fact that these
cells were isolated using the same markers (CD24 − / CD44 + / ESA +).
Zhang, who earned an M.D.
from the Peking University Health Science Center in China and a Ph.D.
from the National University of Singapore, was recruited in 2007 to the Texas team that expected to see an increase of
brain metastasis when PTEN, a known
tumor - inhibiting protein, was artificially deleted in a
tumor cell.
Molecular testing: Some primary
brain tumors, including some of the most common types of gliomas, are defined by their key molecular features resulting
from tumor cell mutations.
The enzyme that degrades these chains is called heparanase, and the researchers found that medulloblastoma
cells, as well as
cells from other childhood
brain tumours, need this enzyme, which may suggest new ways to treat the
tumor.
If he can determine how to speed up engulfment of dead
tumor cells from brain tissue, it is his hope to reduce the harmful inflammation that causes death of surrounding neurons.
He will study how glial
cells recognize and digest dead
cells from a
brain tumor.
The Program specializes in the treatment of primary head and neck cancers,
brain and spine
tumors such as squamous
cell carcinoma, basal
cell cancer, glomus
tumor, paragangliomas, acoustic neuromas, salivary gland and mucosal
tumors, astrocytomas, oligodendrogliomas, glioblastomas, and hemangioblastomas, and metastatic
tumors that may have arisen
from elsewhere in the body such as the breast, lung, or prostate.
Gliomas are
brain tumors that arise
from glial
cells, which help nerve
cells to stay connected and send signals throughout the body.
Primitive Neuroectodermal
Tumors (PNET) and pineoblastoma are a group of tumors defined by their appearance and are thought to develop from primitive (undeveloped) nerve cells in the
Tumors (PNET) and pineoblastoma are a group of
tumors defined by their appearance and are thought to develop from primitive (undeveloped) nerve cells in the
tumors defined by their appearance and are thought to develop
from primitive (undeveloped) nerve
cells in the
brain.
One cohort study in Denmark looked at billing information
from 358,000
cell phone users and then compared it to
brain -
tumor data
from a national cancer registry.
In
cells from certain
brain tumors, in stomach cancer, and in colorectal cancer lines, vitamin K halts the reproductive
cell cycle and induces apoptosis.
Tumors originating in the brain or primary brain tumors arise from cells that are normally found within the brain and men
Tumors originating in the
brain or primary
brain tumors arise from cells that are normally found within the brain and men
tumors arise
from cells that are normally found within the
brain and meninges.
A primary
brain tumor originates
from cells normally found within the
brain and its surrounding membranes.
Glioma - These
tumors arise
from the supporting
cells of the
brain and include astrocytomas, oligodendrogliomas, glioblastoma multiforme and ependymomas.
Authored and submitted a paper for publication, «The Behavior of
Brain Tumor Cells Extracted
From the Pineal Gland Under Spectrum Shifts of UV Light»