Sentences with phrase «from calcidiol»

Not exact matches

While 7 - dehydrocholesterol is tucked tightly within the lipids of skin cell membranes, previtamin D3 is an unstable compound that over a brief period of time converts into vitamin D3, causing it to be released from the cell membrane.12 Vitamin D3 then travels into the blood where it binds to vitamin D - binding protein (DBP).16 Eventually, it is delivered to the liver where it is converted into its primary storage form, calcidiol, which is likewise transported in the blood by DBP.8

Although the newest edition of the authoritative textbook, Vitamin D, claims that in humans calcidiol binds with equal affinity to the DBP whether it is derived from vitamin D2 or vitamin D3, 37 the citation for this statement is the author's own PhD thesis, in which he reported results obtained from testing the DBP of a mere two people.48 Since the gene for the DBP is one of the most polymorphic known (meaning it exists in many forms), existing in three common alleles and 124 known rarer alleles (alleles are specific forms of the same gene), each allele itself having many polymorphisms, 37 a sample size of two is rather unconvincing.

The research cited above, moreover, suggests that vitamin D would be stored in adipose tissue at these levels and released when calcidiol levels drop, as they would during the winter in temperate climates — an added bonus for those who wish to obtain their vitamin D from foods like cod liver oil and fatty fish rather than from supplements during the winter.

1 On his Vitamin D Council web site, Cannell now recommends blood levels of calcidiol between 50 and 80 ng / mL53 and supplementation of 1,000 IU for every 25 pounds of bodyweight.2 For someone weighing between 150 and 175 pounds, he thus recommends between 6,000 and 7,000 IU per day from all sources.