Sentences with phrase «from cell proliferation»

The precise balance between the two compounds controls the transition from cell proliferation to differentiation.

Not exact matches

Transient Silencing of 14 -3-3sigma promotes proliferation of p63 - positive progenitor cells isolated from human breastmilk in mammary epithelial cell culture.

One of the team's new biosensors is made from a nanoplasmonic material that is able to accommodate a large number of cells on a single substrate and to monitor cell proliferation, a fundamental process involving cell growth and division, in real time.

Unlike the differential effect on Treg cell proliferation following PD - L1 blockage, the researchers observed an increase in the proliferation of killer T cells from all HIV study groups, regardless of their viral load.

She got permission from her immediate boss, the lab manager, to use proteins from the atherosclerosis lab for a class project to study cell proliferation.

«Blocking the damage response in normal cells that have been bathed in chemotherapy could be instrumental in keeping errant or dormant cancer cells from starting down the path to proliferation,» he said.

«We demonstrated that alpha - KGDH interacts with Gcn5 in the cell nucleus and found that tumor cell proliferation and tumor growth were inhibited when alpha - KGDH was blocked from entering the cell nucleus or by disruption of Gcn5's binding to succinyl - coenzyme A,» said Lu.

«Bone cells aren't solely studied in isolation in the lab as both local and systemic factors play an important role in their function, so it's important to unpick the multitude of biological factors that can affect their proliferation,» says Dr Pablo Roman - Garcia, a first author from the Wellcome Trust Sanger Institute.

In Arabidopsis, as in most plants, there is a specific zone near the tip of the root where stem cells transition from a stage of proliferation to one where they differentiate into specific tissue types.

Mammalian hairs and avian feathers develop from a similar primordial structure called a «placode»: a local thickening of the epidermis with columnar cells that reduce their rate of proliferation and express very specific genes.

Named after the enigmatic sphinx, this cell signal is important in many activities of living cells, from migration to proliferation.

As an example, he cited his previous research on baked purple potatoes that have compounds that help suppress chronic intestinal inflammation elevated from a high - calorie diet and stem cell proliferation, which are linked to both colitis and colon cancer.

«By analyzing mice with the WNT10A mutation, as well as tissues from human patients with WNT10A mutations, we found that WNT10A regulates the proliferation, but not the maintenance, of stem cells in hair follicles,» said Sarah Millar, PhD, vice chair for Basic Research in the Department of Dermatology.

Monitoring immune cell activity — including phenotyping immune cell subsets, tracking cell proliferation, and measuring cytokine production — can provide insights into the overall status of immune function in patients, particularly those undergoing immunosuppression after transplants, enduring cancer treatment, or suffering from autoimmune disease or other pathologies that affect the immune system.

The phenomenon, known as Warburg effect, is typical for cancer cells and the mechanism behind is believed to benefit cancer cells by switching biochemical engines from energy manufacturing reactions to anabolic reactions, which primarily support growth of the cell size and proliferation.

The laboratory of Marcos Malumbres, who is head of the Spanish National Cancer Research Centre's (CNIO) Cell Division & Cancer Group, working alongside Isabel Fariñas» team from the University of Valencia, shows, in a study published today in the journal Nature Communications, how in mice the elimination of the Cdh1 protein — a sub-unit of the APC / C complex, involved in the control of cell division — prevents cellular proliferation of rapidly dividing ceCell Division & Cancer Group, working alongside Isabel Fariñas» team from the University of Valencia, shows, in a study published today in the journal Nature Communications, how in mice the elimination of the Cdh1 protein — a sub-unit of the APC / C complex, involved in the control of cell division — prevents cellular proliferation of rapidly dividing cecell division — prevents cellular proliferation of rapidly dividing cells.

Using tumor cells from DLBCL patients, the scientists discovered that the inactivation of BTK in resistant tumors triggers the over-activation of alternative signals that promote tumor cell survival and proliferation.

Scientists from the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden recently discovered a new mechanism governing brain stem cell proliferatCell Biology and Genetics in Dresden recently discovered a new mechanism governing brain stem cell proliferatcell proliferation.

In a new paper, Brown University researchers show one: proliferation helps change the NK cells» function from stimulating the immune response to calming it down, lest it get out of hand.

They also found that when under stress from chemotherapy, megakaryocytes signaled fibroblast growth factor 1 (FGF1), to stimulate the proliferation of hematopoietic stem cells.

When GARP was depleted from these cells, there was increase in B cell proliferation and activation.

Their findings outlined four distinct cellular phases of sperm stem cells maturation, revealing how the stem cells progress from a «quiescent» state, to a «proliferation» state during which stem cells divide, to a final «differentiation» state when stem cells mature to become sperm.

They then used human stem cells derived from bone marrow that would normally become bone cells to test the effects of the nanoparticles on stem cell proliferation and differentiation.

We assayed from 6000 to 20,000 shRNAs simultaneously to identify genes important for the proliferation and survival of five cell lines derived from human mammary tissue.

When NGF is withdrawn from the culture medium, the cells retract their fibers, lose their other neuronal properties and resume the uncontrolled proliferation characteristic of neoplastic cells.

More specifically, we found that T cells from DGKζ − / − and Cbl - b − / − mice exhibit similar levels of enhanced proliferation at low levels of TCR stimulation.

The paper «MYC Releases Early Reprogrammed Human Cells from Proliferation Pause via Retinoblastoma Protein Inhibition» was published by Cell Reports on April 10, 2018.

They are broadly expressed in excitable and non-excitable cells, and have in turn been implicated in a large spectrum of physiopathological processes, ranging from the regulation of neuronal excitability, respiratory and cardiac function to the control of cell volume, hormone secretion and cell proliferation.

This supported work from Bartholomew et al 120 showing that the addition of IL - 2 to MLR / MSC co-cultures reduced MSC suppression and restored T cell proliferation.

Deletion of DGKζ from T cells results in prolonged TCR signal transduction downstream of DAG, resulting in enhanced activation of Ras, increased effector T cell proliferation, and amplified cytokine production, which leads to increased antitumor activity against s.c. implanted EL4 tumors or murine mesothelioma (12, 16, 17).

Rapid selection and proliferation of CD133 (+) cells from cancer cell lines: chemotherapeutic implications.

«This idea fits nicely with the findings from a number of groups — that forced expression of cell cycle regulators can induce cardiomyocyte proliferation in mammals,» says Jopling.

Bartonella - induced endothelial cell proliferation is mediated by release of calcium from intracellular stores.

In support of the relevant role of p21 in mediating p53 - dependent cell - cycle arrest, cells derived from p21 - null mice arrest proliferation inefficiently after p53 activation (8, 9, 10).

This alteration likely can be attributed to a combination of decreased persistence of memory T cells (41) and enhanced homeostatic proliferation resulting from increased strength of signal downstream of the TCR (16).

To this end, we are focusing on two aspects of β - cell regeneration: enhancing β - cell proliferation in vivo and stimulating the differentiation of new β - cells from endogenous progenitors in the pancreas.

Mesenchymal stromal cells promote or suppress the proliferation of T lymphocytes from cord blood and peripheral blood: the importance of low cell ratio and role of interleukin - 6.

[3] H. Lin et al., «Influence of decellularized matrix derived from human mesenchymal stem cells on their proliferation, migration and multi-lineage differentiation potential,» Biomaterials, 33:4480 − 9, 2012.

The new knowledge and target candidate genes resulted from such unbiased study are ultimately important for researchers to understand the fundamental nature of stem cell proliferation and differentiation.»

Proto - oncogenes consist of a group of genes / proteins that, when expressed, normally encourage cell survival, growth and proliferation, while tumor suppressors perform the opposite task, keeping cells from dividing out of control.

Thus apart from direct cytotoxic effect, the exposure of cancer cells to therapeutic doses of radiation also enhances the survival and proliferation of a fraction of cells which ultimately leads to radiation resistance and therapeutic inefficacy.

The origins of many of these and other genes specific to animal processes such as cell adhesion, and social control of cell proliferation, death and differentiation can be traced to genomic events (gene birth, subfamily expansions, intron gain / loss, and so on) that occurred in the lineage that led to the metazoan ancestor, after animals diverged from their unicellular «cousins».

Mouse iPS cells are indistinguishable from ES cells in morphology, proliferation, gene expression and teratoma formation.

Deletion of an essential gene from a cell eventually leads to the death of this cell or a severe proliferation defect.

Approximately 50 % of PTCL are unclassifiable and categorized as PTCL, not otherwise specified (PTCL - NOS).1 Using gene expression profiling, PTCL - NOS lymphocytes can be distinguished from normal T lymphocytes, with deregulation of genes involved in apoptosis, proliferation, cell adhesion, and transcription regulation.2 Two subgroups of PTCL - NOS have been identified, which are characterized by high expression of either GATA3 or TBX21 / T - bet transcription factors and downstream target genes.3 However, actionable biomarkers closely related to the pathogenic mechanism need to be further investigated and may become potential therapeutic targets of PTCL - NOS. 4, 5

Results from the previous times (Times 1 - 3) of the Swedish longitudinal OCTO immune study indicated that a combination of high CD8 and low CD4 percentages and poor T - cell proliferation in PBL was associated with a higher 2 - year mortality in a sample of very old Swedish individuals.

However, because p21, p27 and MDM2 are all eumetazoan novelties, this pathway may not have acquired the ability to regulate cell proliferation until after the divergence of sponges from eumetazoans.

Uncoupling cell proliferation from apoptosis and possibly from cell migration can lead to pathologies such as cancer.

Oncogenes — whose protein products, when activated, cause uncontrolled cell proliferation or prevent cells from undergoing apoptosis.

This monolayer of cells appears to be inhibited from dividing in the adult, although these cells have limited proliferation in vitro in response to growth promoting factors and wounding [1 - 3].