Sentences with phrase «from cells involved»

These «wires» are projected from cells involved in receiving incoming odor signals from neurons in the nose, and local cells in the bulb that modulate them — including short axon (SA) cells (brightly illuminated in this view) and external tufted (ET) cells.

Not exact matches

The trial involved an experimental checkpoint inhibitor from Bristol - Myers Squibb called ipilimumab (now marketed as Yervoy)-- whose aim was to release the molecular brakes on her own army of T cells.

One way to enhance eggs, developed by the company OvaScience, involves supplementing an egg with mitochondria taken from stem cells found in the lining of a woman's uterus.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

The case before the justices involves the cutting - edge field of biologics — drugs made from living cells instead of chemicals.

The objects of his study range from a class of molecules that have the basic self - duplicating property of living things, through cells which suggest purely physical systems, through animals which give increasing evidence of having minds, to human beings in whom streams of consciousness seem to involve continual choices of action, at the opposite pole from control by impersonal laws of nature.

GanedenBC30's unique structure safeguards the cell's genetic material from the extreme temperature and pressures involved in the manufacturing process, along with the challenges it's exposed to during digestive transit.

He would never cheat, never deceive, never have someone deflate footballs below the acceptable limits and then destroy his cell phone to keep anyone from finding out how involved he was.

Aside from the basics and generic marvels of modern invention (roof over my head, car, cell phones, internet, elevators, dishwashers, tampons, etc, etc), in my own life and particular circumstances I'm especially grateful for my Ergo baby carrier, very involved and very good Grandparents on both sides, a very involved and very amazing husband, and the luxury of eating out more often than I should.

Th2 cytokines, like interleukin (IL) 4, IL - 5, and IL - 13, are involved in the production of IgE from B cells and are also elevated in the breast milk of allergic mothers (12).

A breast biopsy involves the removal of a small tissue sample from the breast for lab testing to determine if any cancerous cell changes are present.

Both involve a technique called nuclear transplantation — replacing the nucleus of a donor's egg with the DNA from an adult cell.

Previous studies showed that, in depressed patients, lipid rafts sequester a protein involved in cell signaling, called GαS, keeping it from doing its job.

A related paper, involving Svendsen, his colleague Gad Vatine, PhD, and a team from University of California, Irvine, published the same day in the journal Cell Reports, used a similar approach to study Huntington's disease.

In 2011 researchers found that these waves of electricity cause neurons in the hippocampus, the main brain area involved with memory, to fire backward during sleep, sending an electrical signal from their axons to their own dendrites rather than to other cells.

Many of the mutations in ASD, Yan explained, result from chromatin remodeling factors, which are involved in dynamically changing the structure of chromatin, the complex of genetic material in the cell nucleus that condenses into chromosomes.

Marcelo Rivolta of the University of Sheffield in the UK and colleagues extracted cochlear stem cells from aborted fetuses, with the consent of the women involved.

The relevant patents involve the positioning of differentiated retinal cells in the eye and not the creation of these cells and would potentially be exempt from the ruling; his team wrote its patent this way to distinguish it from other stem - cell - based applications — they felt that describing the placement of cells rather than the creation of the cells was likely to be more novel.

«Fat cells can adopt a range of metabolic phenotypes, depending on physiological conditions and location in the body,» said James G. Granneman, Ph.D., a researcher involved in the work from the Center for Integrative Metabolic and Endocrine Research at the Wayne State University School of Medicine in Detroit, MI.

One of the team's new biosensors is made from a nanoplasmonic material that is able to accommodate a large number of cells on a single substrate and to monitor cell proliferation, a fundamental process involving cell growth and division, in real time.

«The pathway mainly involves signalling via the brains» immune cells, and thus differs from how today's drugs operate.

Among those are proteins that contribute to the production of seeds, as well as proteins involved in defending cells from heavy metal and radiation damage.

The researchers have compared various processes involved in gene expression, such as gene transcription and chromatin modification, and have repeated this in different tissues and cell types from both humans and mice.

Research involving the derivation and use of stem cells from adult tissues is permissible, subject to the informed consent of the tissue donor.

Research involving the derivation and use of embryonic stem (ES) cells is permissible only where there is strong scientific merit in, and potential medical benefit from, such research.

Bar coding typically involves sequencing a few short segments of animal DNA from the mitochondria, the mini-organs that produce energy within every cell.

Research involving the derivation and use of stem cells from cadaveric foetal tissues is permissible, subject to the informed consent of the tissue donor.

«Cardiac stem cells from heart disease patients may be harmful: Researchers discover molecular pathway involved in toxic interaction between host cells and immune system.»

Svendsen is more optimistic about his team's work involving human tests of a novel stem cell approach to treat ALS, a degenerative motor neuron disease in which cells that transmit messages from the brain and spinal cord to the muscles wither or die.

Although no clinical trials involving therapies derived from iPS cells are on the books, researchers are currently testing drugs on them.

The team, involving Radha Raman Pandey and David Homolka from the Pillai lab, is now investigating whether the piRNAs follow the same «inchworm» process within mammalian cells, to take them a step closer to understanding the process within humans.

In this way, Louvard believes the institute will gain most from its mix of research disciplines and potential for translational research, involving anything from theoretical physics and pharmacochemistry through cell biology and radiobiology to imaging and bioinformatics.

Another procedure, called pre-implantation genetic diagnosis (PGD), involves removing one or two cells from an early - stage IVF embryo for genetic testing to screen for various diseases.

Almost all of these involve removing cells from an individual's body, editing their DNA and then putting them back into the body.

A team from the Spanish National Cancer Research Centre (CNIO) has determined for the first time the high - resolution structure of a complex (R2TP) involved in key processes for cell survival and in diseases such as cancer.

Indeed, after Siddle added a squirt of interferon - gamma — a chemical messenger that activates numerous genes involved in producing MHC antigens — to cells cultured from devil tumors, the MHC genes functioned normally again, and the tumor cells» identity cards showed up, plain as day.

This is normally used to detect fetal abnormalities such as Down's syndrome, and involves inserting a needle into a pregnant woman's belly to take a sample of amniotic fluid containing cells from her fetus.

When researchers screened a library of more than 200 drugs and related compounds for activity against embryonal subtype tumor cells from three patients, the most promising results involved drugs that increased oxidative stress in tumor cells.

But Pearse had shown that no virus was involved; the cancer cells had transferred directly from one animal to the next.

The process is complex, involving cells that ordinarily protect the neurons from harm.

Current genome sequencing techniques involve the chemical disintegration of samples of red blood cells from infected patients to obtain parasite DNA, which are then sequenced.

No results from trials involving stem cells and multiple heart attack patients had yet been published.

From the moment of fertilization, building a human body involves a series of choices where cells generated by cell division must elect which of the myriad types of cell they will become.

The report, from a committee made up of 11 members of Parliament, also recommends legalizing research involving embryos of chimeras and hybrids, which includes cells created by fusing human and animal nuclei.

To see whether cancer stem cell renewal involves a chain of events similar to that used by embryonic stem cells, and whether the process was affected by oxygen levels, Semenza and graduate student Chuanzhao Zhang focused their studies on two human breast cancer cell lines that responded to low oxygen by ramping up production of the protein ALKBH5, which removes methyl groups from mRNAs.

The disease model, described in a new study by a UC San Francisco - led team, involves taking skin cells from patients with the bone disease, reprogramming them in a lab dish to their embryonic state, and deriving stem cells from them.

The first key experiment involved removing a specific subset of activated T - cells from mouse models.

Those hoping for quick clinical success should remember it takes time for revolutionary treatments to go from lab bench to bedside, says Andras Nagy, a stem cell researcher at Mount Sinai Hospital's Lunenfeld — Tanenbaum Research Institute in Toronto, who has not been directly involved in Yamanaka's work.

This animation guides us through the immune pathways involved in the disease, from the first signs of self - reactive immune cells to joint damage and other symptoms.This article was reproduced with permission and was first published on January 25, 2016.

Further investigation, says Resar, showed that these unusual properties arise from the ability of HMGA1 to turn on several genes involved in the Wnt pathway, a network of proteins necessary for embryonic development and stem cell activity.