Sentences with phrase «from chromosomal»

Using genes from these chromosomal regions, Richter identified three new enzymes that function in terpene synthesis pathways to produce linalool, nerolidol, and other terpenes.

UvrD's job is to unwind these damaged and discarded strands from chromosomal DNA, so that they can be disposed of quickly and the associated repair proteins can go on to catalyze additional rounds of repair.

And we may be able to prevent the pain of recurrent miscarriages from chromosomal abnormalities.

Aside from chromosomal abnormalities, miscarriage during the first trimester can also occur because of the following:

Not exact matches

Even when the risk of a chromosomal abnormality far exceeds the risk of loss from amniocentesis, the mother won't have an amnio unless she feels that the risk of loss is acceptable to her.

Know that chromosomal testing can be performed from the placenta and umbilical cord, and may not require the baby itself.

Week 12: A nuchal translucency exam may be done from weeks 11 - 13 to screen for Down Syndrome and other chromosomal abnormalities.

«Therefore, the activity of enhancers is assessed in a reproducible chromosomal context rather than from a transiently expressed plasmid.

But when Joris Vermeesch from the Centre for Human Genetics in Leuven, Belgium, and colleagues examined 23 embryos from nine young, fertile couples who were undergoing IVF for screening purposes, they found that 21 had chromosomal abnormalities, suggesting these are in fact the norm (Nature Medicine, DOI: 10.1038 / nm.1924).

In a retrospective analysis of clinical trial data, they found that melanoma patients with highly aneuploid tumors were less likely to benefit from immune checkpoint blockade therapy than patients whose tumors showed fewer chromosomal disruptions.

Last year, news reports from Tanzania for instance highlighted the case of a baby chimp suspected of having «Down syndrome,» but chromosomal tests could not be conducted.

Scientists in northern Spain tracking populations of Drosophila subobscura, a type of fly, observed reversible changes in the frequency of genetic mutations, or «chromosomal inversions» in the flies» genomes — essentially, parts of the chromosome get flipped around with the seasons, as the weather changes from hot to cold.

«This pattern in brown bears covers even larger geographic areas than analogous findings from humans, where the Y - chromosomal lineage of Genghis Khan, founder of the Mongol Empire, was spread across much of Asia,» said Tobias Bidon and Frank Hailer, lead authors of the study.

Wapner's narrative follows developments from the recognition of a chromosomal abnormality in cancer cells to the production of a targeted drug against what had been a lethal leukemia.

A randomized phase III trial finding that a new monoclonal antibody, elotuzumab, added to standard therapy, extended the duration of remission for patients with relapsed multiple myeloma by about five months Findings from two phase III studies showing that children with Wilms tumor who have a specific chromosomal abnormality do better with a more intensive, augmented chemotherapy regimen

Proteins called kinesins, for example, are natural nanomotors that support cellular functions such as mitosis (the chromosomal process that creates two nuclei from one parent nucleus) and meiosis (when the number of chromosomes per cell is reduced by one half).

Two of the world's largest professional societies of human geneticists have issued a joint position statement on the promise and challenges of non-invasive prenatal testing (NIPT), a new procedure to test blood drawn from pregnant mothers for Down syndrome and other chromosomal disorders in the fetus.

Because older sperm tend to have more chromosomal mutations — ranging in seriousness from harmless to lethal — there is among older fathers a higher rate of kids born with certain rare tumors, neural - tube defects, congenital cataracts, and upper limb defects.

The relevance of these mutations was reinforced by the fact that many also were found in the same chromosomal regions previously shown to be associated with HLHS from human genetic studies.

Dr. Vasmatzis» research on the «Quantification of Somatic Chromosomal Rearrangements in Circulating Cell - free DNA From Ovarian Cancers» is published in the July 20 edition of Scientific Reports.

If a mother ha sY - chromosomal DNA in her blood, it's a good bet it came from cells that were originally part of a male fetus.

To investigate in more detail, researchers from KU Leuven and elsewhere employed in vitro fertilization in cattle as a flexible system to study chromosomal changes in single embryonic cells.

«Genome of Leishmania reveals how this parasite adapts to environmental changes: Scientists demonstrate that Leishmania adaptation results from frequent and reversible chromosomal amplifications.»

The urinary cells were collected from patients with the chromosomal inversions causing hemophilia to make iPSCs, the team applied CRISPR - Cas9 nucleases (Clustered Regularly Interspaced Short Palindromic Repeats - CRISPR associated protein 9) to them.

Researchers from Sanford Health and Chronix Biomedical today announced that results from a pilot study demonstrating the utility of a new cancer panel to detect previously undetected viral and cancer mutations are to be reported in a poster presentation titled «Detection of novel HPV mutations and chromosomal number imbalance (CNI) in oropharyngeal and laryngeal cancer using next - generation sequencing (NGS)» at the American Society of Clinical Oncology Annual Meeting (ASCO 2014) being held from May 30 through June 3, 2014 in Chicago.

... Although isolated DNA must be removed from its native cellular and chromosomal environment, it has also been manipulated chemically so as to produce a molecule that is markedly different from that which exists in the body.

By analyzing blood samples from more family members, Polymeropoulos's team was able to locate additional chromosomal markers that seemed to be inherited along with the disease.

To avoid detrimental outcome for the organism, cells with mutations that generate deviations from normal chromosomal number are eliminated by cellular protection mechanisms.

Chronic myelogenous leukemia (CML) is a human disease associated with a consistent chromosomal translocation that results in sequences from the c - abl locus on chromosome 9 being fused to sequences in a breakpoint cluster region (bcr) on chromosome 22.

Various procedures are currently available to detect genetic defects in embryos prior to implantation, but these approaches are often invasive, requiring the removal of cells from the growing embryo, and do not simultaneously detect both chromosomal abnormalities and DNA sequence variations associated with genetic disorders.

This «chromosomal disorder» is a key feature of the gibbon genome and has probably occurred after their secession from the ancestral line of the apes and humans.

From a basic research perspective, we have found the first example of a tumor - initiating mutation that directly affects how cells divide, causing chromosomal instability.

By using a proprietary technology, we have shown that we can isolate fetal cells from every pregnant sample and use the DNA from isolated fetal cells to detect chromosomal and sub-chromosomal changes in the fetal genome.

Since genes in our chromosomes are very, very much better protected from mutations than the mitochondrial DNA is, we can rely on the chromosomal copies carrying on working in very nearly all our cells for much longer than a currently normal lifetime.

This subgroup of AML is trickier than APL, where the product of the gene created by the chromosomal rearrangement directly blocks the cancer cells from becoming their normal type.

deCODE was able to narrow the location of the gene to a small chromosomal region, utilizing the genotypes of 2700 volunteer patients and relatives grouped into 200 families from across Iceland.

In eukaryotes, chromosomal rearrangements, such as inversions, translocations and duplications, are common and range from part of a gene to hundreds of genes.

We have evaluated the published data from 27 different chromosomal regions that have been subjected to extensive mutagenesis.

The Y - chromosome haplotype reconstructed for CGG10023 was distinct from those Y - chromosome haplotypes present in the modern horses, supporting previous hypotheses that domestication was associated with a significant loss of Y - chromosomal diversity (12, 26).

Thus, PHENOMIN - ICS resource is able to meet the needs of new models creation, from the punctual mutation to the big chromosomal rearrangement, as well as the needs in high - throughput or specialised phenotyping, for research teams either mouse specialists or not.

We have identified a Y - chromosomal lineage that is unusually frequent in northeastern China and Mongolia, in which a haplotype cluster defined by 15 Y short tandem repeats was carried by approximately 3.3 % of the males sampled from East Asia.

These transcription units come from nearly every division of the genome and have been isolated in chemical and ionizing radiation mutagenesis screens, by insertion of transposons, in chromosomal walks, by molecular sequence similarity, and in mutagenesis screens designed to isolate behavioral mutants as well as mutants with altered brain anatomy.

Forms of variation include single DNA base pair alterations, duplications or deletions of genes or sets of genes, and translocations, a chromosomal rearrangement in which a segment of genetic material from one chromosome becomes heritably linked to another chromosome.

Under the stewardship of Christine Armour, the working group, consisting of members from the CCMG Clinical Practice and Laboratory Practice committees with representatives from the SOGC, have updated the 2001 Canadian guidelines for use of chromosomal microarray analysis (CMA).

From cytogenetic research to genome - wide copy number association from micro-arrays, SVS delivers a powerful toolset for correlating common and rare chromosomal aberrations with diseFrom cytogenetic research to genome - wide copy number association from micro-arrays, SVS delivers a powerful toolset for correlating common and rare chromosomal aberrations with disefrom micro-arrays, SVS delivers a powerful toolset for correlating common and rare chromosomal aberrations with disease.

Genetic variation in tribes of Eastern and North - Eastern India: inference from distribution of Y - chromosomal polymorphisms.

Unlike other methods, chromosomal analysis is able to unambiguously identify cells from all common mammalian species and can also differentiate between cells from the same species.

While meiosis is fundamental to sexual reproduction and key components of meiotic machinery for chromosomal synapses and recombination are conserved from yeast to mammals [2], [76], the absence of Boule homologs in fungi together with the requirement of Boule homologs in only one sex of animals suggest that conservation of Boule is unlikely due to the same functional constraint that keeps components of meiotic machinery conserved.

We have analyzed Y - chromosomal variation in populations from Transoxiana, a historical region covering the southwestern part of Central Asia.

Future studies, including data from larger sample sizes of wild - born and geographically well - defined individuals, and full Y - chromosome sequences from bonobos, gorillas and orangutans, promise to further our understanding of population histories, male - biased behaviours, mutation processes, and the functions of Y - chromosomal genes.