Sentences with phrase «from cisplatin»

Injecting kenpaullone into the middle ear protected both mice and rats from cisplatin - induced hearing loss.

Zuo and colleagues identified multiple compounds that protected cochlear cells from cisplatin, several of which are already approved to treat other conditions.

Not exact matches

A team of researchers led by Dr. Jian Zuo screened over 4,000 drugs for their ability to protect cochlear cells from the chemotherapy agent cisplatin.

In the case of cisplatin - induced hearing loss, kenpaullone appears to protect hair cells by preventing CDK2 from stimulating the production of toxic reactive oxygen species from the cells» mitochondria.

Moreover, use of the gel led to significantly lower levels of cisplatin in liver tissue 5 centimetres away from the cancer, and in the kidneys.

The researchers then compared tumor cells isolated from multiple different breast cancer patients and found that cells expressing lower amounts of Numb - 1 and -2 were more resistant to the chemotherapy agent cisplatin.

Patients with epidermal growth factor receptor (EGFR) expressing advanced squamous non-small-cell lung cancer benefit most from necitumumab added to gemcitabine and cisplatin chemotherapy, according to a subgroup analysis from the SQUIRE trial presented today at the European Lung Cancer Conference (ELCC) 2016 in Geneva, Switzerland.

In the current work we used adenoviral - type 5 (dE1 / E3)(Cytomegalovirus promoter) with human ABCA10 transgene (Ad - h - ABCA10) purchased from Vector Labs ® in order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatin.

Aerosol administration was performed as follows, the residual cup was filled with 8mls of the cisplatin agent and the nebulisation time was 10 minutes (almost 1 ml / minute) as observed from our previous studies.14 The aerosol was delivered to the mice (one by one) within a nose only cage that has been previously presented.34 In the groups receiving the intratumoral cisplatin an insulin injection was used to deliver the 2mls of cisplatin within the tumor in different depths, however; a quantity of the drug when the injection was made superficially was lost since it was not accumulated.

The chemotherapy drug was obtained from our Lung Cancer Oncology Unit; i) Cisplatin / Hospira ® 100mg / ml ONCO - TAINTM.

The limitations of the chemo beads Although cisplatin beads are often effective at preventing or slowing the cancer from coming back, they do not prevent spreading (metastasis), e.g. to the lungs.

Cisplatin is then slowly released from the beads, which are reabsorbed by the body over 4 - 6 weeks.