Sentences with phrase «from combination studies»

Not exact matches

Studies have estimated 3 % of the U.S. population suffer from the pain and numbness of carpal tunnel syndrome (although the jury is still out as to whether its causes are genetic, occupational or a combination of the two).

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Results from a preclinical study conducted in collaboration with researchers at Beth Israel Deaconess Medical Center evaluating the combination of a proprietary investigational oral toll - like receptor 7 agonist, GS - 9620, and a proprietary investigational broadly neutralizing antibody, as part of an HIV eradication strategy.

«Based on the results from these Phase 3 studies, the combination of bictegravir and FTC / TAF could represent an important advance in triple - therapy treatment for a broad range of HIV patients, and we look forward to submitting regulatory applications in the U.S. and EU this year.»

Ward and Loughlin are engaged in sophisticated cultural criticism, parody, irony, and a fluid combination of discourses from postmodern philosophy, Christian tradition and gender studies, and both their style and content seem ill at ease with confident programmatic statements and a preference for Augustine / Aquinas as the theological «default setting.»

, the 2014 film from Spanish director Alberto Rodríguez which is still making the festival circuits here in the States, is a haunting combination of detective tale and truth - and - reconciliation case study.

A recent study took a bunch of peaches from different places and found that together, the peaches contained a combination of 53 different pesticides.

I learned the process to make the plant - based cheeses while studying at Matthew Kenney Culinary in California, from there it's just been experimenting and playing with new flavor and consistency combinations!

In combination with the studies from Harvard, this book set barefoot running ablaze.

i think the data from this study could be evidence to convince all the stakeholders that only a combination of nutrition education in the classroom and offering ONLY healthy options (no hot sandwiches and pizza w / chocolate milk every day) will help put a dent in kids horrible eating habits and their resulting bad health.

Although not directly comparable, our findings are in broad agreement with those from routine data in Scotland that have indicated a positive association between Baby Friendly accreditation, but not certification, and breastfeeding at 1 week of age.17 Our findings reinforce those of Coutinho and colleagues who reported that high exclusive breastfeeding rates achieved in Brazilian hospitals implementing staff training with the course content of the Baby Friendly Hospital Initiative were short - lived and not sustained at home unless implemented in combination with post-natal home visits.35 Similarly in Italy, training of staff with an adapted version of the Baby Friendly course content resulted in high breastfeeding rates at discharge, with a rapid decrease in the days after leaving hospital.36 In contrast, a cluster randomized trial in Belarus (PROBIT) found an association between an intervention modelled on the Baby Friendly Initiative with an increased duration of breastfeeding37 an association also reported from an observational study in Germany.38 Mothers in Belarus stay in hospital post-partum for 6 — 7 days, and in Germany for 5 days, with post-natal support likely to be particularly important in countries where mothers stay in the hospital for a shorter time, with early discharge likely to limit the influence of a hospital - based intervention.

One study indicates that babies fed a combination of formula and breastmilk are roughly 4 % more at risk for death due to diarreahal illnesses, and babies that are exclusively formula fed are about 14 % more at risk for death from diarreahal illnesses (Victoria, 1989).

«A combination of practical scenario and case study questions, with more conceptual essay questions, will test a range of skills essential to the international tax profession, from determining a client's tax position based on an understanding of applicable legislation, to offering analysis, evaluation and advocacy on a topical issue in international tax discourse.»

Four - week quit rates from the study were 23 percent for placebo; 36 percent for the patch; 49 percent for Zyban; and 58 percent for the combination of Zyban and the patch.

The difference between Paleoamerican and modern Native American facial features is likely a combination of additional waves of migration from Siberia, via Beringia, and genetic drift, a gradual change in appearance and other traits as populations divide, migrate and adapt, says Jim Chatters, a Seattle - area anthropologist who led the multinational study of Naia.

But she concludes: «Ultimately, the role of diet in MS is an actively evolving area of research that will be further enriched by complementary evidence derived from a combination of interventional as well as high quality longitudinal observational studies.»

Now a new study led by researcher Eduardo Maeda from the University of Helsinki has put together a unique combination of satellite data and hydrological measurements to study the problem.

Using a combination of engineering and scientific knowledge gained from field studies, as well as interaction with communities in developing countries, some researchers in our department are developing methods to effectively communicate information about best practices to the farmers, as well as methods to train them by example.

Each major agricultural region highlighted in the study experienced a slightly different combination of factors that correlate with increased ammonia in the air from 2002 to 2016.

After studying this result, the NANOGrav team determined that the reported non-detection was not a surprise, and resulted from the combination of optimistic gravitational wave models and analysis of too few pulsars.

In the study, the researchers then used a combination of different techniques to map the connections from the habenula to the frontal area of the brain, and to precisely control the activity of neurons in these regions.

Dr Sian Clarke from the London School of Hygiene & Tropical Medicine, also a principal investigator in the research, said: «This study shows that rapid diagnostic tests can improve the use of artemisinin - based combination therapies — the most effective treatment for malaria — in drug shops, but it's not without its challenges.

The researchers from the Artemisinin - based Combination Therapy (ACT) Consortium at the Ministry of Health in Uganda and the London School of Hygiene & Tropical Medicine in the UK carried out the study because up to 80 % of malaria cases in Uganda are treated in the private sector.

The new study, led by Professor Scott, found that the most cost effective strategy for the tourism industry to meet the United Nations» recommended targets of reducing carbon emissions, includes a combination of strategic energy saving and renewable energy initiatives within the industry and buying carbon offsets from other parts of the global economy where emission reductions can be done at less cost.

Optimism about combination therapy with artemisinin - related drugs is tempered by a recent study finding that the malaria parasite may be only one simple mutation away from becoming resistant to artemisinin.

«We show that the earthquake rate in the Salton Sea tracks a combination of the volume of fluid removed from the ground for power generation and the volume of wastewater injected,» said Emily Brodsky, a geophysicist at the University of California, Santa Cruz, and lead author of the study, published online in Science on July 11.

Then, in 2002, a 16,000 - women study named the Women's Health Initiative (WHI) dropped a bombshell: participants were likelier to suffer from heart attacks and breast cancer if they took combination estrogen and progestin hormones.

Their study, which appears as a letter in the Sept. 8 edition of Nature Medicine, expands on work published in April showing that a combination of ribavirin and interferon - alpha 2b stops MERS - CoV from replicating in cell culture.

A new study from the University of Eastern Finland shows that the combination of manual therapy and exercise is an excellent way to combat movement control impairment in the lower back.

Using research about genetically modified foods and trans fats, study participants were randomly assigned to evaluate one of 15 different partnership scenarios that included varying combinations of scientists from a university, a government agency, a non-governmental organization and a large food company.

A total of 2489 adults with COPD on tiotropium (TIO), long - acting beta - agonist inhaled corticosteroids (LABA / ICS), and / or short - acting bronchodilators (SAB) alone or in combination were studied using retrospective data from the COPDGene study and prospective data from the telephone and web - based biannual Longitudinal Follow - Up program.

The study was largely funded by a combination of fellowships from the Environmental Protection Agency and the UW NASA Space Grant Consortium, and grant support from the National Science Foundation (NSF).

Many countries across Africa and Asia - Pacific may be vulnerable to Zika virus outbreaks, with India, China, the Philippines, Indonesia, Nigeria, Vietnam, Pakistan, and Bangladesh expected to be at greatest risk of Zika virus transmission due to a combination of high travel volumes from Zika affected areas in the Americas, local presence of mosquitos capable of transmitting Zika virus, suitable climatic conditions, large populations and / or limited health resources, according to a new modelling study published in The Lancet Infectious Diseases.

«This cooling reduced precipitation over Africa, and in combination with a range of other complex climate feedback mechanisms tipped the humid system towards aridification,» explains the first author of the study, James Collins from Helmholtz Centre Potsdam — GFZ German Research Centre for Geosciences and Alfred Wegener Institute — Helmholtz Center for Polar and Marine Research (AWI) in Bremerhaven.

The study is investigator led and has therefore focused on clinical need, targeting patients with progressive multiple sclerosis in whom most disability is incurred... The study also reports a predominant effect on neurodegenerative rather than inflammatory outcomes, suggesting a novel mechanism of action that might be suitable as combination treatment with immunomodulatory treatments... Further phase 3 studies to measure the effect of simvastatin on sustained disability, particularly in patients with non-relapsing secondary progressive and primary progressive multiple sclerosis, are clearly needed, but this trial represents a promising point from which to develop trials of progressive disease.»

This result follows from the combination of kinetic studies in Munich, advanced spectroscopic analysis in Amsterdam and theoretical modeling in Eindhoven.

In a joint study, clinical pharmacologist Markus Zeitlinger and gastroenterologist Werner Dolak from MedUni Vienna showed that this combination of medication can result in inflammation in the small intestine.

The finding, in combination with evidence from previous studies, suggests that these molten regions deep below, near the core - mantle boundary of the Earth, may cause basaltic ocean island chains to form along the surface.

Starting in the 1990s, a series of studies suggested that many women who took a combination of estrogen and progestin as they grew older would suffer less from heart disease.

Lucina Uddin, Ph.D., assistant professor in the Department of Psychology at the University of Miami, who was not part of the research team, said, «The combination of multiple neuroimaging modalities is a clear strength of the current study, and the authors are to be commended for undertaking the difficult task of trying to reconcile results from methods designed to tap different aspects of brain structure and function.

The researchers note that the most likely response from industry will involve a combination of the approaches outlined in the study, and although there is a high level of uncertainty in the estimates, the findings provide much needed evidence on the relative effects of different industry responses, and the possible magnitude of health outcomes.

Their properties are still difficult to ascertain, however, because the combination of interference from dust and the low spatial resolution of submillimeter telescopes prevents further study at other wavelengths.

«In combination with findings from human studies, work with chimpanzees can provide enormous insights into core biobehavioral processes relevant to psychological illness and health,» said Robert Latzman, lead author of the study and assistant professor in the Department of Psychology at Georgia State.

In the absence of such trials, mathematical models can help assess the effectiveness of different HIV intervention combinations, as demonstrated in a new study by Elisa Long and Robert Stavert from Yale University in the US.

Hence, a total of 90 patients from nine centers were randomly assigned to one of two study arms for the phase II clinical trial: the first taking capsules of olaparib (400 mg twice daily) and the other taking a combination of the two drugs (200 mg olaparib in capsule - form twice daily and 30 mg tablets of cediranib once daily).

Combination therapy with two immunotherapy drugs produces an unprecedented doubling of response rates from 20 percent to 40 percent, a new study shows.

A study of asthma patients in seven U.S. cities, reported in tomorrow's issue of The New England Journal of Medicine, found that a combination of allergy to cockroaches and exposure to the insects made some children much more likely to suffer from severe asthma.

The results from our new study suggest that entinostat may enhance the anti-tumor efficacy of PD - 1 targeted therapy through MDSC targeting, potentially providing an effective combination treatment approach for patients with solid tumors, including lung and renal cell carcinoma.»

But in a new study, Canadian researchers found that a combination treatment of antibodies and virus - fighting proteins prevented death from Ebola - Zaire in some primates, even when administered three days after infection and when the early symptoms of the fever, which include fatigue and vomiting, begin to show.

The new study, led by Giulio Maria Pasinetti, PhD, Saunders Professor of Neurology, and a team of investigators from the Center for Integrative Molecular Neuroresilience at the Icahn School of Medicine at Mount Sinai, found that a bioactive dietary polyphenol preparation — a combination of three grape - derived polyphenol products, including a select Concord grape juice, a select grape seed extract, and trans - resveratrol — was effective in promoting resilience against stress - induced depression in mice.