Sentences with phrase «from copy number»

Use this set of files when interested in identifying CNVs (compared to the reference) in samples that exhibit widespread or long - range divergence from a copy number of two across all autosomal chromosomes.

As an example, skeletal malformations and dysplasias, often detected through routine prenatal ultrasound examination, constitute a phenotypic finding in more than 300 syndromic and non-syndromic disorders and their genetic etiology may be due to a wide variety of genetic aberrations, ranging from copy number variations to single gene mutations.

A scientist explains the early, exciting findings from copy number variation (CNV) studies

Not exact matches

If the box's channels don't have your entertainment options covered, you can easily copy video onto a USB stick and plug it in, with a number of channels / apps such as Plex also helping with streaming from a computer.

While some rights holders have argued that the standard for a substantial is very low (the National Post recently argued in a case that «even the reproduction of a small number of words in a newspaper article can be an impermissible reproduction»), the Copyright Board says that its preliminary view is that «copying of a few pages or a small percentage from a book that is not a collection of short works, such as poems, is not substantial.»

Misunderstanding your buyer can manifest itself in many ways; poor campaign performance or a rise in email unsubscribes due to irrelevant messaging, dwindling conversion rates from mis - targeted website copy, failing sales numbers due to unqualified leads plus a lack of effective training and sales enablement materials, and more.

In this video I'm going to show you a great way to get better keywords out of the Google Adwords Keyword tool if you haven't seen the previous video you'll want to watch that video where I show you how to get better search volume numbers from both google adwords as well as some other sources to get better estimates for the amount of times that keyword is searched each month i'll put a link in the video here so that you can click that video if you haven't seen that yet let's get started now if you want better results from the Google Adwords Keyword planner you have to work a little differently than everyone else so most people come to the Google Adwords Keyword planner and they simply click on this search for new keywords using a phrase, website, or category and then they just paste a bunch of keywords into this text box so let's say as an example that these were our starting keywords ok so let's say we have the keywords «fishing tips» «fishing tackle» «fishing for bass» «fishing rod» and «fishing reel» what most people do is that they would simply come here and they would copy this they would paste it into this field and they would hit Search and they would get back their results and that's fine but one little tip that will help you get much better results is only paste in one key word at a time so instead of pasting all these in just paste in the single keyword «fishing tips» and then proceed from there to pull that those results up and you'll get this back if you click right here you can download the ideas you'll notice they're 701 here listed so if we download these ideas will download them to a CSV file comma separated value file you can open that with notepad you can open it with excel open office when you're finished putting all your ideas and individually you will now have a bunch of different common separate value files containing the keywords and the search volume I've already gone ahead and done that just to save time on the video but i want to show you what happens when you use this method versus just pasting in the keywords like most people do so here you'll see this column here represents these two columns here represent if we had pasted in all of the keywords at once and click search at google adwords keyword tool is one that showed you and you'll see we have a total of 706 results we got back when we did that this column this column here represents what happens when we paste one key word at a time and then download the file paste the second keyword download the file and then we just simply grab those terms and copy them and you'll see now we have a total of 1,915 keywords now what I've done with the highlighting here is to show you anything that's not highlighted in this column is a keyword we would not have gotten back had we pasted in all the keywords at once you can see there's lots and lots of keywords here we would not have seen know your competitors and the company's you're competing against they're using probably the simple method just pasting a bunch of keywords sitting search and then looking through those terms to find their terms if you will take the extra few minutes it takes doesn't take long to simply go in and paste one key word at a time you will get back a ton of great keywords that others aren't seeing because they're using this other method and in actuality when I ran the numbers there's a total of 3.8 million searches represented by these keywords here that you would miss if you simply just copied and pasted those five terms and hit search the Google Adwords Keyword planner once you've used the google keyword planner to find lots of new keyword ideas what do you do with all those keywords the biggest problem is that you can there are so many keyword tools out there you can get hundreds of thousands of keywords by spending a day using the different keyword tools but what you do with all that information the answer is a cool tool called keyword grouper pro and Keyword Grouper Pro is completely free there's not even an opt in you just simply download the tool now at the top of this video there's a link if you click that i'll show you exactly how to use keyword grouper pro doesn't matter where you got your keywords from i'm going to show you how to take those keywords group them into tight groups and then you can set up your campaigns and know exactly which groups represent buyers and once you know where the buyers are at you can simply focus your marketing in that area to make more profit in your business

Well, judging by all the footnote numbers in there, I think he copied and pasted straight from Wikipedia..

That Gospel was by far was the most widely used early Christian book, to judge by the number of copies that have surfaced in the dry sands of Egypt, or by the number of quotations in early Christian writers, or by the number of textual corruptions introduced from Matthew into other Gospels by scribal copyists obviously more familiar with Matthew.

Now if the true issue is so clearly defined in the article — THE ISSUE OF WHAT THE LOST MUST BELIEVE TO BE SAVED — and I believe it is, and like I said, I can scan my own copy of the article with with notes and numbering in my own handwriting — and if your position on this issue is so Biblically solid, then why do you not deal with the real issue at hand, rather than raising all these sorts of protests and all this fuss about the author that can be directly quashed by quotes from the articles?

Copies of texts supplied by Matt Seaton and Chris Sharpe, as well as photos of pictures and winners from the «Images of Fathers» exhibition (in print and email format) are available from Fathers Direct and from the Lloyds TSB Foundation (contact numbers attached).

Here are the numbers again, copy and pasted from above:

and you were the one throwing around Cuomo's numbers, which obviously you made up or just copied from Cuomo as you're doing research now.

So for political judgment, the numbers from the copied table should maybe be corrected by including the percentage of adults who are taxed at 0 $.

So his campaign released a television ad as rudimentary as any broadcast that political season, featuring a number of prominent politicians — City Council Speaker Christine Quinn, West Side Congressman Jerry Nadler, Manhattan borough president Scott Stringer — carrying a folded copy of The New York Times, while reading from its endorsement of his candidacy.

A copy of the results from the «Big Question» on pupil behaviour is attached, along with details of a number of «refusal to teach» ballots taken by the NASUWT during 2011 on pupil indiscipline.

«Our biggest concern is, number one, with the different ethics proposals that have come from the governor, that what applies to the Legislature should apply to the governor,» he said, holding up a copy of the chamber's semi-annual expenditure report.

Ban could not extract an adequate amount of DNA from the sample, so he increased the number of polymerase chain reaction DNA - copying rounds to try to increase the chance of obtaining usable profiles.

Gingerich, who was feted in the opening ceremonies with an honorary degree from the university (and also given a fitted, blue velvet academic cassock tailored to his measurements), focused his presentation on the number of surviving copies of the Rudolphine Tables.

It utilizes specific, immobilized probes that can be interrogated using DNA from normal and diseased sources, providing a wealth of information on copy number changes throughout the genome at much finer resolution than has been previously achievable.

Anita Thapar of Cardiff University, UK, and colleagues screened DNA from 366 children with ADHD and 1047 without for copy - number variants (CNVs)-- specific regions of DNA that were either missing or duplicated.

The team integrated three, complementary gene sequencing approaches to look for mutations in tumor cells from SS patients: whole - genome sequencing in six subjects, sequencing of all protein - coding regions (exomes) in 66 subjects, and comparing variation in the number of copies of all genes across the genome in 80 subjects.

Extra bases are easily added or lost when the DNA is copied, so the number of repeats in each of these stretches, known as microsatellites, varies widely from one individual to another.

Biotechnologist James Dale and colleagues at Queensland University of Technology in Brisbane, Australia, cloned a resistance gene named RGA2 from a type of wild banana that's impervious to TR4 and inserted it into the Cavendish, creating six lines with varying numbers of RGA2 copies.

Using clinical, genetic, and gene expression data as filters to distinguish genes whose copy number alteration causes cancer from those for whom copy number changes are incidental, the team whittled down their list from 14,000 to a more manageable number, each of which they systematically tested using genetic experiments in animals.

Results from the analysis confirmed previous findings of some copy number variants already associated with autism, but they also found a host of other genes (SHANK2, SYNGAP1, DLGAP2 and the X chromosome — linked DDX53 - PTCHD1 locus) in which mutations seem to be linked to autism.

The two Univerity of Washington studies, «Great ape genetic diversity and population history,» published in Nature, and «Evolution and diversity of copy number variation in the great ape lineage,» published in Genome Research, are funded by NIH grant HG002385 and support from the Howard Hughes Medical Institute.

First author Baoshan Xu, Ph.D., a former postdoctoral research associate in the Gerton Lab now starting his own lab at Sun Yat - sen University in China, worked with Hua Li, Ph.D., to use computational methods to count the number of copies of ribosomal DNA in normal and cancer cells of 162 patients from the eight projects.

Scherer and his colleagues, who included population geneticist Matthew Hurles of the Wellcome Trust Sanger Institute in Cambridge, England, followed up with a higher - resolution CNV study in 2006, which analyzed DNA from 270 individuals and identified an average of 47 copy number variations per person.

For example, part of a description of a method for karyotyping — examining the number and structure of chromosomes in a cell — was not only copied from a paper published by a separate group, but was also not consistent with the procedure actually followed by Obokata's team.

Citing the growing body of evidence of links between copy number variations and diseases such as autism, an international science consortium announced yesterday that it plans to sequence the genomes of 1,000 people from around the world in an attempt to flush out genetic suspects.

There are a number of viruses that have a similar way of copying themselves — a process that reverses the normal flow of information in cells, which is where the term «retro» comes from — and their central machinery for replication may be a bridge from the original life - forms on this planet to what we know as life today.

Enhanced starch digestion through extreme AMY2B copy number expansion has been postulated to be an adaptation to the shift from the carnivorous diet of wolves to the starch - rich diet of domesticated dogs30.

Although none of the German Neolithic samples carries the copy number expansion of the AMY2B gene associated with starch digestion, we find that this gene is present in three copies in NGD, though this is due to a large segmental duplication that is shared with multiple modern dogs, an event separate from the tandem AMY2B duplications.

This is consistent with recent findings that AMY2B copy number is highest in modern dog populations originating from geographic regions with prehistoric agrarian societies, and lowest from regions where humans did not rely on agriculture for subsistence34 and supports the claim that the expansion occurred after initial domestication (possibly after the migration of dingoes to Australia 3,500 — 5,000 years ago) 34.

This suggests that aside from neocentromere formation, mechanisms that reduce satellite copy number could account for the small amount of CentO at rice centromere 8.

It is thought to be due to a complex interplay between polygenic and various environmental risk factors, although recent reports on genomic copy number variations suggest that a fraction of the cases could result from variably penetrant de novo variants.

From the measurements we infer copy - per - cell numbers for the transcripts, and we develop mathematical models to describe the kinetics of regulation.

Using this technology, we screened 31 patient samples across an array containing a total of 162 exons for five disease genes and detected copy - number changes, ranging from whole - gene deletions and duplications to single - exon deletions and duplications, in 100 % of the cases.

Over the next few years genes from different bacterial (and eventually mammalian) species were cloned into plasmids and new cloning vectors such as pBR322, pACYC, and pUC were developed to provide higher copy number vectors that could be used in these cloning experiments.

From cytogenetic research to genome - wide copy number association from micro-arrays, SVS delivers a powerful toolset for correlating common and rare chromosomal aberrations with diseFrom cytogenetic research to genome - wide copy number association from micro-arrays, SVS delivers a powerful toolset for correlating common and rare chromosomal aberrations with disefrom micro-arrays, SVS delivers a powerful toolset for correlating common and rare chromosomal aberrations with disease.

Many patients suffering from Rare Disease harbour genomic variants (sequence variants or copy number variants) that by disrupting normal gene expression lead to disease.

Developing novel tools to quantify gene expression in single cells As it has become increasingly apparent that gene expression in individual cells deviates significantly from the average behavior of cell populations, new methods that provide accurate integer counts of mRNA copy numbers in individual cells are needed.

To identify additional alterations, the investigators looked at DNA copy number changes, or changes in gene number resulting from the deletion or amplification (multiplication) of sections of DNA in the genome.

Methods: Sixty - eight parasites isolates with in vivo clearance data were obtained from two Tracking Resistance to Artemisinin Collaboration study sites in Cambodia, culture - adapted, and genotyped for pfkelch13 and other mutations including pfmdr1 copy number; and the RSA0 - 3h survival rates and response to antimalarial drugs in vitro were measured for 36 of these isolates.

Additionally, copy number aberrations inferred from the Ion Torrent sequencing were compared to single nucleotide polymorphism arrays and found to be 59 % concordant on average.

By performing a meta - analysis of rare coding variants in whole - exome sequences from 4,133 schizophrenia cases and 9,274 controls, de novo mutations in 1,077 family trios, and copy number variants from 6,882 cases and 11,255 controls, we show that individuals with schizophrenia carry a significant burden of rare, damaging variants in 3,488 genes previously identified as having a near - complete depletion of loss - of - function variants.

By analyzing genome sequence data from human populations, including 1269 individuals from sub-Saharan Africa, we identify a diverse array of large copy number variants affecting the host invasion receptor genes GYPA and GYPB We find that a nearby association with severe malaria is explained by a complex structural rearrangement involving the loss of GYPB and gain of two GYPB - A hybrid genes, which encode a serologically distinct blood group antigen known as Dantu.

We describe the principles that underlie subclonal reconstruction through single nucleotide variants (SNVs) or copy number alterations (CNAs) from bulk or single - cell sequencing.

Joey then followed up with an analysis of DNA copy number data derived from the same primary melanoma tumours.