Sentences with phrase «from cytotoxic»

p53 - Based cyclotherapy: exploiting the «guardian of the genome» to protect normal cells from cytotoxic therapy.

«Myeloid - derived suppressor cells (MDSCs) produce reactive nitrogen radicals that alter the receptors on the surface of the tumour to hide it from cytotoxic lymphocytes that kill tumour cells.

Not exact matches

Histone deacetylase (HDAC) inhibitors have shown promise in «flushing out» HIV from latently infected cells, potentially exposing the reservoirs available for elimination by cytotoxic T lymphocytes (CTL), also called killer T cells.

The researchers also analyzed specific immune cells called cytotoxic T cells isolated from the patients» blood and found increases in biomarkers indicative of immune activation.

They are designed to get around one of the ways that cancer protects itself from the immune system: tumors can activate the body's natural protective response from autoimmunity, called a checkpoint, and thereby thwart cytotoxic T cells.

In healthy skin, CD49a + and CD49a cells are dormant, but quickly respond with inflammatory and cytotoxic effects when stimulated by IL - 15, a protein secreted from skin cells as a rapid - response defence against microbial attack.

«We studied human T cells, isolated from blood donors of all ages, to compare mature cytotoxic T cells with naive ones,» said Philip Ansumana Hull, graduate student in Ott's lab and one of the first authors of the study.

First, new drugs could be developed to strengthen SIRT1 to rejuvenate mature cytotoxic T cells or keep them from progressing too quickly into a highly toxic state.

«We had some indication that rapamycin would enhance the cytotoxic T cell effect, from previous experiments in both animals and humans showing that the drug produced modest effects by itself,» says Maria Castro, Ph.D., senior author of the new paper.

Anichini A, Maccalli C, Mortarini R, Salvi S, Mazzocchi A, Squarcina P, Herlyn M, Parmiani G. Melanoma cells and normal melanocytes share antigens recognized by HLA - A2 - restricted cytotoxic T cell clones from melanoma patients.

New research from La Jolla Institute for Allergy and Immunology lays the groundwork to parse how the virus interacts with its host and causes disease by pinpointing CD8 + T cells, a subset of T cells more commonly known as cytotoxic or killer T cells, as important gatekeepers that control Zika infection or limit the severity of disease.

These agents will possibly increase the cytotoxic action of MDR - related drugs by preventing the extrusion of anticancer drugs from the target cells.

Our data suggests that targeting DGKζ could prove to be a more useful clinical approach to augment cytotoxic T cell activity against tumor than targeting Cbl - b, perhaps resulting from enhanced Ras / ERK signaling.

Thus apart from direct cytotoxic effect, the exposure of cancer cells to therapeutic doses of radiation also enhances the survival and proliferation of a fraction of cells which ultimately leads to radiation resistance and therapeutic inefficacy.

CD8 (+) cytotoxic and CD4 (+) helper / inducer T cells develop from common thymocyte precursors that express both CD4 and CD8 molecules.

This is associated with a relative reduction in cytotoxic T - cell activity and a reduced capacity to destroy infected host cells and clear the virus from infected lung tissue.

In cancer, Tregs are recruited by tumors and prevent other types of T cells, including cytotoxic T cells (also called CD8 cells) from attacking and destroying cancer cells.

Since amiodarone HCL is known to exert its cytotoxic effect through the extrinsic, caspase - 9 independent apoptotic pathway [33] our microarray results confirm that the differential cytotoxic effect seen in NSCs treated with amiodarone HCL is due to specific activation of extrinsic apoptosis pathways resulting from exposure to the drug.

Importantly, this automated screening assay allowed us to interrogate some of the specific molecular mechanisms that may be responsible for the targeted cytotoxic effect amiodarone HCL had on NSCs and not cells differentiated from NSCs.