Gender differences in vascular reactivity to endothelin - 1 (1 — 31) in mesenteric arteries
from diabetic mice
As shown in Fig. 2 A, treatment with 1 % islet homogenate
from diabetic mice leads to punctated accumulation of thioflavin S (ThS)-- positive amyloid aggregates in cultured islets.
To turn this into something that could one day be a viable therapy for people, the team took stomach stem cells
from diabetic mice, engineered them with the same genes and grew mini-organs.
«Our compound clears lipids
from the diabetic mouse liver, whereas rosiglitazone has the opposite effect,» said Saez.
Not exact matches
The researchers found that these electric currents were much weaker in eyes
from all three strains of
diabetic mice than in healthy
mice.
The drug, SRT1720, kept
mice with high - calorie diets
from becoming obese or
diabetic, according to a study published in Cell Metabolism [subscription required].
Probing the link between adiponectin deficiency and metabolic disorders like diabetes and obesity, researchers
from the Albert Einstein College of Medicine in New York City injected adiponectin into wild - type
mice,
diabetic mice, and obese
diabetic mice.
Remarkably, the same healing effect was produced when B cells
from older obese
diabetic mice were applied to acute wounds in similarly aged, obese
diabetic mice.
For the current study the team first isolated mature B cells
from the spleens of
diabetic and nondiabetic
mice.
By transferring part of the gut bacteria
from healthy
mice to
diabetic mice, they are re-establishing a normal level of cathelicidin.
The genetically obese and
diabetic mice showed similar metabolic benefits
from both WBV and exercising on the treadmill.
When pancreas cells containing clumps of misfolded IAPP, taken
from an engineered
diabetic mouse, were mixed in a dish of healthy human pancreas cells, it triggered the clumping of IAPP in the human cells.
(A) Isolated islets
from 3 - wk - old, female, Tg - hIAPP
mice were cultured in presence of different concentrations of islet extracts (IE)
from old Tg - hIAPP
mice, with overt
diabetic pathology and age - matched WT
mice.
The inoculum was obtained
from old
diabetic mice (fasting plasma glucose > 360 mg / dl), following a similar experimental paradigm as presented in Fig. 3.
Groups of male, IAPP, Tg
mice were injected i.p. at 4 wk of age with 10 % pancreas homogenate
from male,
diabetic, IAPP Tg
mice or 50 µM IAPP aggregates prepared
from synthetic source.
To rule out that the induction observed was due to other
diabetic - associated alterations in the pancreas, we performed a control experiment in which we injected Tg - hIAPP
mice with pancreas homogenate
from a
diabetic model not associated with IAPP aggregation.
Introducing extracellular vesicles secreted
from the GMSCs of healthy
mice reduced wound healing time in
diabetic mice.
To further validate our result in clinical samples, we obtained primary tumor
from patients with advanced breast cancer and the tissue was passaged once in nonobese
diabetic / severe combined immunodeficient
mouse without in vitro culture.
S2 shows that injection of pancreas homogenate
from STZ - induced
diabetic mice does not affect IAPP aggregation.
hIAPP was depleted
from the islet homogenate of
diabetic Tg - hIAPP
mice, using a cocktail of sequence - specific and conformational antibodies.
In fact, metabolic benefits were almost the same for genetically obese and
diabetic mice from both WBV and those exercising on the treadmill.
Researchers at Georgetown University Medical Center have taken tissue
from human testicles that produce sperm, grafted them onto
diabetic mice and showed that blood sugar levels can be controlled for up to a week because they produce insulin.
, Rhaponticin
from rhubarb rhizomes alleviates liver steatosis and improves blood glucose and lipid profiles in KK / Ay
diabetic mice, 2009
In this study we demonstrate that anthocyanins
from blueberry have the potency to alleviate symptoms of hyperglycemia in
diabetic C57b1 / 6J
mice.
A Canadian study, developed by researchers E Arany, B Strutt, et al,
from Lawson Health Research Institute, St. Joseph's Health Care, London, Ontario, investigated whether supplements of the amino acid taurine would inhibit the development of diabetes in the offspring of
diabetic mice.
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