«We are thrilled to establish this partnership with Roche, with the goal of changing the way drug discovery and development is done —
from early discovery, all the way to the clinic,» said Geraldine A. Hamilton, President and Chief Scientific Officer of Emulate.
«This is the first instance I am aware of where an academic drug discovery group moved a molecule designed to hopefully treat a chronic brain disorder all the way
from early discovery to human trials without there being, at some point along the way, a pharmaceutical partner,» said P. Jeffrey Conn, Ph.D., Lee E. Limbird Professor of Pharmacology in the Vanderbilt University School of Medicine and director of the Vanderbilt Center for Neuroscience Drug Discovery (VCNDD).
CPhI North America is your opportunity to meet the entire pharma eco-system,
from early discovery to commercialization, offering you access to the right partners at any stage of development.
Not exact matches
«Cosmic background radiation is well explained as radiation left over
from an
early stage in the development of the universe, and its
discovery is considered a landmark test of the Big Bang model of the universe.»
8) «This conclusion serves to corroborate the inference made by Soviet archaeologists
from their
discovery of camel - headed wagons that as
early as the first half of the third millennium B.C. two - humped camels were used in Turkmenistan for drawing wagons...» The Camel and the Wheel, Richard W. Bulliet p155
Cellard, a French scholar
from Collège de France, told the Daily Mail: «This is a very important
discovery for the history of the Qur «an and
early Islam.
I must admit that I derive a certain amount of personal satisfaction
from their new
discovery, as I'm now able to tap my long - dormant Guy Knowledge, a rich trove of encyclopedic detail stored away
from my
earliest years.
One can trace the history of organizational behavior studies
from early «scientific management» days through the
discovery of «human relations.
The full texts of the Council's reports can be read on - line at their web - site Religious
from The Start A recent
discovery of carved - ivory artefacts in caves in south - western Germany have served to demonstrate more clearly than ever that
early man had an innate spiritual dimension.
It is impossible, for instance, to analyze the dismantling of slavery in the late eighteenth and
early nineteenth centuries apart
from a host of political developments — specifically liberal ones, but also specifically Christian ones, derived in part
from evangelical missionary attitudes and
discoveries.
It was not until 1990 and the
discovery of an old tin containing hundreds of black and white photos
from the
early Ocean Island days that the reality of what they had spoken of finally came to life.
Benefiting
from discovery and play in our
Early Childhood program, skill - building in our Lower School, and rigorous intellectual challenges in the High School, Green Meadow students go on to top colleges, fulfilling careers, and are known for their resilience and creativity.
This
early result
from the survey is just a taster of the new
discoveries still to come, as the survey continues to fill in blind spots in our maps of the Magellanic Clouds.
«First Face of America,» a new NOVA documentary airing February 7 on PBS, provides a closeup look at two dangerous underwater expeditions that resulted in the
discovery and salvaging of bones
from one of the
earliest known New World residents, dubbed Naia.
This lecture illustrates the
early stages in the planning and
discovery of propranolol, an adrenaline beta - adrenergic receptor antagonist, and cimetidine, a histamine H2 - receptor antagonist — the first examples of clinically useful drugs
from each of these classes.
The
discovery confirms that some of the building blocks of life were delivered to the
early Earth
from space.
The Hubble Space Telescope's recent
discovery of the
earliest known Type Ia supernova
from more than 10 billion years ago, plus other results, favor a scenario in which two white dwarfs merge.
Professor Danielle Schreve,
from the Department of Geography at Royal Holloway, said: «This
discovery is critical for establishing the timing and route of
early human dispersal into Europe.
This timeline highlights key
discoveries about our closest relatives,
from early fossil finds to the publication of the draft nuclear genome sequence.
But the
discoveries reported this year — including fossils
from northwestern Africa — point to an
earlier evolutionary phase when the human skeletal portrait was incomplete.
Robert Pruitt, whose team at Purdue University in West Lafayette, Indiana, US, made this extraordinary
discovery, thinks that the mutant genes are being repaired using RNA templates inherited
from earlier generations.
Nevertheless, Canadian job opportunities in drug
discovery are on the rise, Harack declares, as the local biotechnology industry enters its «
early teen» phase, growing
from early stage R&D to development and commercialization.
Marijn Franx, a member of the team
from the University of Leiden highlights: «The
discovery of GN - z11 was a great surprise to us, as our
earlier work had suggested that such bright galaxies should not exist so
early in the Universe.»
More than 80 percent of all drug candidates in the pharma R&D suffer
from poor solubility and are therefore rejected
early in the drug
discovery process.
Chandra X-ray Observatory Center Background about
earlier discovery of x-rays
from galaxy's black hole Technical report on previous Chandra observations of Sagittarius A * NASA article on x-ray flare
The
discovery of 9,000 - year - old flint tools made
from local stone — the
earliest such tools found in the European part of Turkey — helps fill a gap in the story.
More recent fossil
discoveries in the same region, including the iconic 3.7 million year old Laetoli footprints
from Tanzania which show human - like feet and upright locomotion, have cemented the idea that hominins (
early members of the human lineage) not only originated in Africa but remained isolated there for several million years before dispersing to Europe and Asia.
The
early data
from this survey is what led to the
discovery of Virgo I.
If the recent
discovery of gravitational waves emanating
from the
early universe holds up under scrutiny, it will illuminate a connection between gravity and quantum mechanics and perhaps, in the process, verify the existence of other universes
«Alzheimer's in a dish: Stem cells
from patients offer model and drug -
discovery platform for
early onset form of disease.»
«The recent
discovery of tumor - promoting milieus, referred to as metastatic niches, that are established at distant sites prior to or upon the arrival of disseminated tumor cells could explain cancer cells that relapse
early, but in late relapsing populations, what tumor cells do
from the time of dissemination to the time they become clinically detectable has been a big question.»
This had been predicted as a relic
from when hot ionized plasma of the
early universe first cooled sufficiently to form neutral hydrogen and allow space to become transparent to light, and its
discovery led to general acceptance among physicists that the Big Bang is the best model for the origin and evolution of the universe.
The authors claim the
discovery «represents one of the most significant records of a marine Paleocene bird
from the Southern Hemisphere» and supports the»em erging view that most modern birds were already diversified in the
earliest Paleogene».
The
discovery of the site in eastern Siberia also hints that people might have moved
from the Old World into the Americas at a much
earlier date than believed.
LHCb collected the data back in 2011 and 2012, but Wilkinson's team held back
from announcing their
discovery to avoid the fate of those who had made the
earlier claims of pentaquark sightings.
More evidence of an
earlier formation date for the Manson crater comes
from the
discovery in South Dakota of flawed grains of quartz, feldspar and zircon.
Ellis adds that one of the deposits dates as far back as the 4th century, which he says is a particularly valuable
discovery, since few other ritual deposits survived
from that
early stage in the development of Pompeii.
Nevertheless, this
discovery is one of the
earliest and most thought - provoking groups of sculpture
from European prehistory.
This latest
discovery comes a week after a lab in Albany, N.Y., found high concentrations of aminopterin (a rat poison) in samples
from over 60 million cans and pouches of moist meals recalled
earlier this month by Canadian company Menu Foods.
The
discovery of this quasar, named SDSS J0100 +2802, marks an important step in understanding how quasars, the most powerful objects in the universe, have evolved
from the
earliest epoch, only 900 million years after the Big Bang, which is thought to have happened 13.7 billion years ago.
Still, global searches could have some utility, he concedes, as long as they do not distract researchers
from searches targeted at specific phenomena, adding that he is «not convinced that one would be able to use such a search for an
early discovery at the LHC.»
Seeking solutions for all these challenges, the new Gladstone
discovery builds on
earlier research
from Dr. Greene's lab, published in Cell in 2010.
An archeologist
from Florida Atlantic University's Harbor Branch Oceanographic Institute is among a team of scientists who made a groundbreaking
discovery in Huaca Prieta in coastal Peru — home to one of the
earliest and largest pyramids in South America.
That has not only caused large pharma companies to back away
from early - stage drug
discovery, but it has forced them to pursue primarily large - market blockbuster drugs for common conditions such as heart disease and cancer, while avoiding medicines for rare diseases.
This is the
earliest known human consumption of oats, say Marta Mariotti Lippi at the University of Florence in Italy and her colleagues, who made the
discovery after analysing starch grains on an ancient stone grinding tool
from southern Italy (PNAS, DOI: 10.1073 / pnas.1505213112).
He has a Ph.D.
from the University of Virginia in biophysics, a B.A. in chemistry and environmental studies
from the University of Pennsylvania, and
early career experience in pharmaceutical
discovery research.
«The project team's result is an excellent example of how a small amount of catalytic funding
from ARPA - E can help build the foundation to hopefully turn scientific
discoveries into low - cost,
early - stage energy technologies.»
Spanning the chemistry demands
from late
discovery /
early development through to product launch and beyond, our experience enables a scientifically unbiased consultative approach in order to deliver timely process development solutions.
According to Jena, the team is still
early in its
discovery process, but hope that these findings may move the work
from theory to the experimental phase.
The platform is part of MD Anderson's Moon Shots Program, launched in 2013 to reduce cancer deaths by accelerating development of therapies, prevention efforts and
early detection
from scientific
discoveries.