Sentences with phrase «from embryonic mice»

The conversion rate was lower, but the induced neurons seemed just as much like their natural counterparts as those produced from embryonic mouse fibroblasts.

Not exact matches

Cyclooxygenase - 2 (COX - 2) was highly elevated by capsaicin treatment in tumors and murine embryonic fibroblasts from TRPV1 / KO mice.

Here (from left to right), they're shown on the embryonic skin of a mouse, a snake, a chicken and a Nile crocodile.

During embryonic development of mice, however, the situation is different: To build up the system, all mature blood and immune cells develop much more rapidly and almost completely from stem cells.

The research team used mass spectrometry to compare phosphorylation of proteins from mouse embryonic stem cells with fully functioning GSK - 3 to cells in which the gene encoding GSK - 3 had been deleted.

The paper doesn't include any genetic analysis of the final eggs that confirms they are healthy, notes Mitinori Saitou, a stem cell biologist at Kyoto University in Japan whose team developed methods to create mouse egg cells from embryonic or reprogrammed stem cells.

Starting in the mid-2000s, Yoshiki Sasai's team at the RIKEN Center for Developmental Biology in Kobe, Japan, demonstrated how to grow brainlike structures using embryonic stem cells, first from mice and then humans.

The scientists first compared mouse megakaryocyte cells created from embryonic stem cells engineered to lack p45 - Nfe2 with normal megakaryocytes.

In the past few months, researchers in the United States and Japan have described a promising way of deriving embryonic stem cells from skin cells (of mice) without destroying embryos — the «Holy Grail of biotechnology,» as The Times of London put it.

One of the greatest came in November 2007, when scientists in Japan and the United States reported that they could make adult skin cells from mice revert to the embryonic state.

Beginning with mouse egg cells, Daley and his team tricked these egg cells, or oocytes, into thinking they had been fertilized (a process called parthenogenesis) and managed to isolate embryonic stem cells from the subsequent early mouse embryos.

A tooth grown from embryonic cells has been successfully transplanted into the jaw of a mouse.

Mice generated from embryonic stem cells in which ion channel genes have been mutated by homologous recombination often have a perfectly normal heart.

Using mouse embryonic stem cells that generate motor neurons as a model, the researchers found that CTCF isolates Hox genes from harmful activation.

Renee Reijo Pera, a biologist at Stanford's Institute for Stem Cell Biology and Regenerative Medicine, points out that earlier attempts to create offspring with sperm from embryonic stem cells resulted in short - lived mouse pups that were either giants or midgets.

Manuel Eguren has analysed the biological consequences of Cdh1 elimination in rapidly dividing cells, as part of his doctoral research project in Malumbres's group; he focused on progenitors from the nervous system during embryonic development in mice.

Niakan and colleagues predicted from earlier work with mice and human embryonic stem cells that the protein OCT4 would be necessary for the epiblast cells to develop correctly.

Embryonic stem (ES) cells, harvested from three - and - a-half-day-old mouse embryos or five - and - a-half-day-old human embryos, are referred to as pluripotent because they can become any of the thousands of cell types in the body.

Researchers from the University of California, Berkeley, have found a way to reprogram mouse embryonic stem cells so that they exhibit developmental characteristics resembling those of fertilized eggs, or zygotes.

The current research team, which includes Dr. Minoda and Dr. Hiroki Takeda of Kumamoto University, and several researchers from Keio University, have successfully grafted human iPS - derived cells into the inner ear of embryonic mice, a feat with a high level of technical difficulty.

Still, the genetic homogeneity of largely inbred mouse strains may be misleading when it comes to understanding human stem cells, cautions Peter Andrews, professor of biomedical science and co-director of the Centre for Stem Cell Biology at the University of Sheffield, U.K. «In the human, every embryonic stem cell that we're working with that comes from a different person is genetically different,» says Andrews.

There is promising news today for those who hope to turn the potential of undifferentiated stem cells into medical miracles: Researchers are reporting a way to produce insulin - producing cells from mouse embryonic stem cells.

Studying mouse embryonic stem cells, they removed Grb2, a protein essential to the ability of the stem cell to transform into other cell types, from the cells.

When the FGF8 gene was injected into or removed from the front part of the brains of embryonic mice, structures toward the front became elongated or foreshortened, respectively.

Expanding from their previous studies with mice, the researchers first established that under specific conditions, culturing human embryonic stem cells with fibroblast growth factor 2 (FGF2) leads to neural differentiation particular to the midbrain / hindbrain region — the location of the cerebellum — within three weeks, and the expression of markers for the cerebellar plate neuroepithelium — the part of the developing nervous system specific for the cerebellum — within five.

The researchers did this by injecting the cells into embryonic pancreatic tissue taken from mice engineered to lack neurogenin 3.

The researchers took skin cells from the tails of sickle cell mice and inserted copies of four genes that made the cells take on the characteristics of embryonic stem cells.

Intact genome from one particular mouse embryonic stem cell.

The researchers have illustrated the structure in accompanying videos, which show the intact genome from one particular mouse embryonic stem cell.

Scientists at the Massachusetts Institute of Technology (M.I.T.) report that they silenced symptoms of Parkinson's disease in rats using skin cells from an adult mouse that they reprogrammed to act like embryonic stem cells.

The IMPC envisages a ten year programme to undertake a broad - based, systematic genome - wide phenotyping project of knockout mice generated from the embryonic stem cell mutant resources developed by the International Knock - out Mouse Consortium (IKMC).

The goal of this protocol (written in French) is to describe the steps and quality controls to prepare new stable murine embryonic stem cells lines: ① either from wild type mouse embryos to introduce a mutation by genetic targeting or homologous recombination to get a genetically modified mouse line ② or from genetically modified mouse embryos with two aims:

KOMP2 and IMPC researchers will begin by creating lines of knockout mice from embryonic stem cells produced by KOMP.

«Induction of Pluripotent Stem Cells From Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors,» by Kazutoshi Takahashi and Shinya Yamanaka, Cell, Aug. 25, 2006.

A second method involves introducing the transgenic DNA into embryonic stem cells (ES cells) derived from a mouse embryo at the very early stages of development.

This approach is now being used to derive embryonic stem cells from a variety of strains including disease models from which in vitro tools are in demand, including mouse models of Alzheimer's disease, cytogenetic disorders (Turner's syndrome and Down syndrome), and tool strains for systems genetics.

Embryonic germ cells from mice and rats exhibit properties consistent with a generic pluripotent ground state

The embryonic stem cells need a host embryo in which to develop and this is isolated usually from a mouse with different colour fur.

Platelets generated from human embryonic stem cells are functional in vitro and in the microcirculation of living mice.

Yamanaka is renowned for first creating embryonic - like cells from mouse, and later from human cells.

The majority of gene - targeting experiments in mice are performed in 129Sv - derived embryonic stem (ES) cell lines, which are generally considered to be more reliable at colonizing the germ line than ES cells derived from other strains.

Embryonic Stem Cells: While bone marrow donor centers were being established in the 1980s, another stem cell family tree branch was developing that would draw much attention: Nearly 30 years ago, embryonic stem cells were isolated from early - stage mouseEmbryonic Stem Cells: While bone marrow donor centers were being established in the 1980s, another stem cell family tree branch was developing that would draw much attention: Nearly 30 years ago, embryonic stem cells were isolated from early - stage mouseembryonic stem cells were isolated from early - stage mouse embryos.

Mouse brain tissue from three different stages of the mouse brain development; embryonic day 15, postnatal day 2 and postnatal day 21, was stuMouse brain tissue from three different stages of the mouse brain development; embryonic day 15, postnatal day 2 and postnatal day 21, was stumouse brain development; embryonic day 15, postnatal day 2 and postnatal day 21, was studied.

Starting with transplants of human oligodendrocytes in the late 1980s [40], and more recently with populations of human oligodendrocyte progenitor cells isolated from the developing or adult CNS, or from human embryonic stem cells, it has been possible to generate extensive myelination upon transplantation into spinal cord injury or into congenital mouse models of hypomyelination [41]--[48].

For instance, MEF cells are usually made of fibroblasts from the mouse embryos at embryonic day 13.5 and only cells at early passages (p2 to p3) are used as feeders for derivation and culture of embryonic stem (ES) and iPS cells.

Most Alkbh1 deficient mice die during embryonic development, and survivors are characterized by defects in tissues originating from the ectodermal lineage.

InvivoSciences makes engineered heart tissues from mouse embryonic stem cells and stem cells from differentiated adult tissues in humans, such as fat and skin.

Both human embryonic stem cells (hESC) and induced pluripotent stem cells (iPSC) can colonize the mouse embryo in a manner predicted from classical developmental fate mapping and faithfully recapitulate tissue - specific fate post-transplantation.

Derivation of completely cell culture - derived mice from early - passage embryonic stem cells.

Shi, Y.; Desponts, C.; Do, J. T.; Hahm, H. S.; Scholer, H. R.; Ding, S. Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small - molecule compounds.